4.7 Article

Discovery and evaluation of aza-fused tricyclic derivatives for detection of Tau pathology in Alzheimer?s disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Radiosynthesis, In Vitro and In Vivo Evaluation of [18F]CBD-2115 as a First-in-Class Radiotracer for Imaging 4R-Tauopathies

Anton Lindberg et al.

Summary: CBD-2115, a first-in-class 4R-tau radiotracer, showed high binding affinity and reliable synthesis, holding potential for further research on 4R-tauopathies.

ACS CHEMICAL NEUROSCIENCE (2021)

Article Medicine, Research & Experimental

Synthesis and Evaluation of Fluorine-18 Labeled 2-Phenylquinoxaline Derivatives as Potential Tau Imaging Agents

Kaixiang Zhou et al.

Summary: This study evaluated three pairs of optically pure F-18-labeled 2-phenylquinoxaline derivatives as potential Tau imaging agents for AD diagnosis, showing high selectivity and affinity for Tau tangles over A beta. The PET probes (R)-[F-18]5 and (S)-[F-18]16 demonstrated promising brain penetration, kinetics, and stability, making them suitable candidates for Tau tangle imaging.

MOLECULAR PHARMACEUTICS (2021)

Review Chemistry, Medicinal

Tauvid (TM): The First FDA-Approved PET Tracer for Imaging Tau Pathology in Alzheimer's Disease

Caitlin V. M. L. Jie et al.

Summary: Tauvid, approved by the FDA in 2020 for PET imaging in AD patients, is a significant advancement in the field of AD research. This review summarizes the production, quality control, clinical application, pharmacology, and limitations of Tauvid, while also providing an overview of second-generation tau PET tracers.

PHARMACEUTICALS (2021)

Review Clinical Neurology

Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research

Christina M. Moloney et al.

Summary: Neurofibrillary tangles, a hallmark of Alzheimer's disease, undergo a dynamic process of maturity that impacts neuron biology and cognitive function. The levels of maturity include pretangles, mature tangles, and ghost tangles, with distinct characteristics observed through tau protein immunostaining and morphologic changes. Post-translational modifications of tau play a significant role in therapeutic targeting strategies for cognitive dysfunction.

ALZHEIMERS & DEMENTIA (2021)

Article Chemistry, Medicinal

PI-2620 Lead Optimization Highlights the Importance of Off-Target Assays to Develop a PET Tracer for the Detection of Pathological Aggregated Tau in Alzheimer's Disease and Other Tauopathies

Heiko Kroth et al.

Summary: The study tested the candidate compound PI-2014 in healthy controls and Alzheimer's disease patients, and eventually optimized the compound structure to obtain the best candidate PI-2620 with high Tau binding, low MAO-A binding, good brain uptake, and fast and complete brain washout.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Chemistry, Medicinal

Synthesis and bioevaluation of technetium-99 m/rhenium labeled phenylquinoxaline derivatives as Tau imaging probes

Fan Yang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Clinical Neurology

Tau Imaging in Neurodegenerative Diseases Using Positron Emission Tomography

Yi Ting Wang et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2019)

Article Neurosciences

[18F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series

Marta Marquie et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

Tau PET imaging in neurodegenerative tauopathies-still a challenge

Antoine Leuzy et al.

MOLECULAR PSYCHIATRY (2019)

Article Neurosciences

18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal

Christopher M. Lee et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Article Multidisciplinary Sciences

Cryo-EM structures of tau filaments from Alzheimer's disease

Anthony W. P. Fitzpatrick et al.

NATURE (2017)

Article Neurosciences

Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson's case

Marta Marquie et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2017)

Article Radiology, Nuclear Medicine & Medical Imaging

18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease

Ryuichi Harada et al.

JOURNAL OF NUCLEAR MEDICINE (2016)

Article Neurosciences

An autoradiographic evaluation of AV-1451 Tau PET in dementia

Val J. Lowe et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)

Review Biochemistry & Molecular Biology

Characteristics of Tau and Its Ligands in PET Imaging

Ryuichi Harada et al.

BIOMOLECULES (2016)

Article Radiology, Nuclear Medicine & Medical Imaging

[18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease

Ryuichi Harada et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2015)

Article Chemistry, Medicinal

Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future

Manuela Ariza et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Neurosciences

Visualization of regional tau deposits using 3H-THK5117 in Alzheimer brain tissue

Laetitia Lemoine et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)

Article Clinical Neurology

[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

Chun-Fang Xia et al.

ALZHEIMERS & DEMENTIA (2013)

Article Neurosciences

Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807

David T. Chien et al.

JOURNAL OF ALZHEIMERS DISEASE (2013)

Review Clinical Neurology

Tau pathology and neurodegeneration

Maria Grazia Spillantini et al.

LANCET NEUROLOGY (2013)

Article Neurosciences

A Highly Selective and Specific PET Tracer for Imaging of Tau Pathologies

Wei Zhang et al.

JOURNAL OF ALZHEIMERS DISEASE (2012)

Article Clinical Neurology

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

Michelle T. Fodero-Tavoletti et al.

Editorial Material Medicine, Research & Experimental

The Revitalized Tau Hypothesis on Alzheimer's Disease

Ricardo B. Maccioni et al.

ARCHIVES OF MEDICAL RESEARCH (2010)

Review Pharmacology & Pharmacy

PET radiotracers: crossing the blood-brain barrier and surviving metabolism

Victor W. Pike

TRENDS IN PHARMACOLOGICAL SCIENCES (2009)

Article Chemistry, Medicinal

Novel imidazo[1,2-a]naphthyridinic systems (part 1): Synthesis, antiproliferative and DNA-intercalating activities

Mounir Andaloussi et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2008)

Review Neurosciences

Tau exon 10 alternative splicing and tauopathies

Fei Liu et al.

MOLECULAR NEURODEGENERATION (2008)

Article Biochemistry & Molecular Biology

High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation

Alex Crowe et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Multidisciplinary Sciences

Imaging of CNS myelin by positron-emission tomography

B Stankoff et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

Tau suppression in a neurodegenerative mouse model improves memory function

K SantaCruz et al.

SCIENCE (2005)

Article Medicine, General & Internal

Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline

J Näslund et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2000)