Causal association of genetically determined circulating vitamin D metabolites and calcium with multiple sclerosis in participants of European descent

Editorial Material Cardiac & Cardiovascular Systems

Genetic evidence for vitamin D and cardiovascular disease: choice of variants is critical

Stephen Burgess et al.

EUROPEAN HEART JOURNAL (2022)

Article Endocrinology & Metabolism

Genetically Predicted Lifelong Circulating 25(OH)D Levels are Associated With Serum Calcium Levels and Kidney Stone Risk

Zhongyu Jian et al.

Summary: The study found that higher genetically predicted lifelong circulating 25(OH)D levels are associated with higher calcium levels and KSD risk. The effects of 25(OH)D on KSD were partially attenuated but still significant in MVMR.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Mendelian randomization study updates the effect of 25-hydroxyvitamin D levels on the risk of multiple sclerosis

Renxi Wang

Summary: This study using Mendelian randomization (MR) methods, found a causal association between genetically increased serum 25OHD levels and reduced risk of multiple sclerosis (MS) in the European population.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

添加到收藏夹

Review Endocrinology & Metabolism

The health effects of vitamin D supplementation: evidence from human studies

Roger Bouillon et al.

Summary: The review highlights that vitamin D supplementation in vitamin D-replete adults does not provide significant health benefits, but vitamin D deficiency should be corrected. The vitamin D supplementation can prevent and cure nutritional rickets in infants and children.

NATURE REVIEWS ENDOCRINOLOGY (2022)

添加到收藏夹

Article Clinical Neurology

Effects of Vitamin D and Body Mass Index on Disease Risk and Relapse Hazard in Multiple Sclerosis A Mendelian Randomization Study

Marijne Vandebergh et al.

Summary: Serum 25-hydroxyvitamin D levels and body mass index have causal effects on the risk of multiple sclerosis, with serum 25-hydroxyvitamin D levels also significantly associated with relapse hazard.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2022)

添加到收藏夹

Review Clinical Neurology

Full spectrum of vitamin D immunomodulation in multiple sclerosis: mechanisms and therapeutic implications

Manon Galoppin et al.

Summary: Vitamin D plays an important role in multiple sclerosis by modulating the immune system, reducing disease activity and progression. It affects the differentiation of immune cells, regulates innate immune cells, and reduces immune cell trafficking at the blood-brain barrier. Additionally, Vitamin D reduces activation of glial cells within the central nervous system, potentially providing neuroprotective effects.

BRAIN COMMUNICATIONS (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Maternal and Neonatal 3-epi-25-hydroxyvitamin D Concentration and Factors Influencing Their Concentrations

Di Mao et al.

Summary: This study found that 3-epi-25(OH)D3 is present in both maternal and neonatal circulation and contributes to a portion of total 25(OH)D. Factors such as having a male fetus, ambient solar radiation, maternal glycemia, and vitamin D levels were associated with maternal 3-epi-25(OH)D3 levels, while advanced maternal age, multiparity, inadequate gestational weight gain, maternal glycemic status, and earlier gestational age at delivery were significantly associated with higher umbilical cord serum 3-epi-25(OH)D3 levels.

JOURNAL OF THE ENDOCRINE SOCIETY (2022)

添加到收藏夹

Article Clinical Neurology

An atlas on risk factors for multiple sclerosis: a Mendelian randomization study

Shuai Yuan et al.

Summary: The study found that childhood and adulthood body mass index were positively associated with MS, while physical activity and serum 25-hydroxyvitamin D were inversely associated with MS. Additionally, possible associations were found for type 2 diabetes, waist circumference, body fat percentage, age of puberty, and high-density lipoprotein cholesterol in relation to MS. Data from systematic review suggested that exposure to organic solvents, Epstein Barr virus and cytomegalovirus infection, and diphtheria and tetanus vaccination were also associated with MS risk.

JOURNAL OF NEUROLOGY (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Relationship between Serum Nutritional Factors and Bone Mineral Density: A Mendelian Randomization Study

Zihao Qu et al.

Summary: The study found that serum levels of calcium and selenium are associated with bone mineral density at specific skeletal sites, indicating that these nutritional factors play crucial roles in bone metabolism.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

添加到收藏夹

Article Clinical Neurology

The relative contributions of obesity, vitamin D, leptin, and adiponectin to multiple sclerosis risk: A Mendelian randomization mediation analysis

Adil Harroud et al.

Summary: Obesity is associated with increased risk of MS, partially mediated by lowered vitamin D levels, while leptin and adiponectin have no effect.

MULTIPLE SCLEROSIS JOURNAL (2021)

添加到收藏夹

Article Nutrition & Dietetics

Impact of serum calcium levels on total body bone mineral density: A mendelian randomization study in five age strata

Jing-yi Sun et al.

Summary: This study provides genetic evidence that increased serum calcium levels do not improve bone mineral density in the general population. Elevated serum calcium levels in generally healthy populations, especially in adults older than 60 years, may even reduce bone mineral density. Results are consistent with recent Mendelian randomization findings.

CLINICAL NUTRITION (2021)

添加到收藏夹

Review Endocrinology & Metabolism

Hormonal regulation of biomineralization

Andrew Arnold et al.

Summary: This article discusses the physiological and pathological aspects of hormonal regulation of biomineralization, emphasizing the importance of mineral intake, serum concentrations of mineral, and hormonal regulators in this process. It also highlights the crucial role of biomineralization in providing rigidity and flexibility to the skeleton, and the balance required for proper skeletal metabolism.

NATURE REVIEWS ENDOCRINOLOGY (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Genetically Determined Serum Calcium Levels and Markers of Ventricular Repolarization A Mendelian Randomization Study in the UK Biobank

William J. Young et al.

Summary: The study found that a decrease in serum calcium concentration is associated with longer QT and JT intervals on the ECG, potentially indicating a causal relationship. A weak association was also observed for QRS duration, with results being consistent in all sensitivity analyses.

CIRCULATION-GENOMIC AND PRECISION MEDICINE (2021)

添加到收藏夹

Review Clinical Neurology

Vitamin D supplementation in multiple sclerosis: an expert opinion based on the review of current evidence

Robin Boltjes et al.

Summary: There is currently no solid evidence to support the use of vitamin D therapy in treating MS, although there are promising results in clinically isolated syndrome (CIS) patients and young MS patients early after diagnosis. Further large-scale clinical trials are recommended to investigate the effects of vitamin D supplementation in MS, particularly in selected patient groups such as CIS patients and young patients at the time of diagnosis, aiming to reach a level of 100 nmol/l with vitamin D-3 supplements.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Association of Genetic Variants Related to Serum Calcium Levels with Reduced Bone Mineral Density

Gloria Hoi-Yee Li et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2020)

添加到收藏夹

Article Multidisciplinary Sciences

A robust and efficient method for Mendelian randomization with hundreds of genetic variants

Stephen Burgess et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Clinical Neurology

BMI and low vitamin D are causal factors for multiple sclerosis A Mendelian Randomization study

Benjamin M. Jacobs et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2020)

添加到收藏夹

Article Clinical Neurology

Vitamin D and Disease Severity in Multiple Sclerosis-Baseline Data From the Randomized Controlled Trial (EVIDIMS)

Priscilla Baecker-Koduah et al.

FRONTIERS IN NEUROLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

Joana A. Revez et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Review Nutrition & Dietetics

Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases-An Umbrella Review

Friederike Maretzke et al.

NUTRIENTS (2020)

添加到收藏夹

Review Nutrition & Dietetics

Vitamin D Supplementation in Multiple Sclerosis: A Critical Analysis of Potentials and Threats

Julia Feige et al.

NUTRIENTS (2020)

添加到收藏夹

Editorial Material Medicine, General & Internal

Health effects of vitamin and mineral supplements

Fang Fang Zhang et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

添加到收藏夹

Article Medicine, General & Internal

The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis

Ju-Sheng Zheng et al.

PLOS MEDICINE (2020)

添加到收藏夹

Review Mathematical & Computational Biology

Meta-analysis and Mendelian randomization: A review

Jack Bowden et al.

RESEARCH SYNTHESIS METHODS (2019)

添加到收藏夹

Article Medicine, General & Internal

Genetic predisposition to increased serum calcium, bone mineral density, and fracture risk in individuals with normal calcium levels: mendelian randomisation study

Agustin Cerani et al.

BMJ-BRITISH MEDICAL JOURNAL (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Genetic Prediction of Serum 25-Hydroxyvitamin D, Calcium, and Parathyroid Hormone Levels in Relation to Development of Type 2 Diabetes: A Mendelian Randomization Study

Shuai Yuan et al.

DIABETES CARE (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Association of Plasma Vitamin D Metabolites With Incident Type 2 Diabetes: EPIC-InterAct Case-Cohort Study

Ju-Sheng Zheng et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2019)

添加到收藏夹

Article Clinical Neurology

Multiple sclerosis is associated with low bone mineral density and osteoporosis

Etienne J. Bisson et al.

NEUROLOGY-CLINICAL PRACTICE (2019)

添加到收藏夹

Article Medical Laboratory Technology

C3-epimerization of 25-hydroxyvitamin D increases with increasing serum 25-hydroxyvitamin D levels and shows a high degree of tracking over time

Julia M. Kubiak et al.

CLINICAL BIOCHEMISTRY (2018)

添加到收藏夹

Article Endocrinology & Metabolism

Calcium and Vitamin D Supplementation Are Not Associated With Risk of Incident Ischemic Cardiac Events or Death: Findings From the UK Biobank Cohort

Nicholas C. Harvey et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2018)

添加到收藏夹

Article Clinical Neurology

Mendelian randomization in multiple sclerosis: A causal role for vitamin D and obesity?

Adil Harroud et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

添加到收藏夹

Article Genetics & Heredity

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

Marie Verbanck et al.

NATURE GENETICS (2018)

添加到收藏夹

Article Clinical Neurology

Mendelian randomization in multiple sclerosis: A causal role for vitamin D and obesity?

Adil Harroud et al.

MULTIPLE SCLEROSIS JOURNAL (2018)

添加到收藏夹

Article Geriatrics & Gerontology

Circulating vitamin E levels and Alzheimer's disease: a Mendelian randomization study

Guiyou Liu et al.

NEUROBIOLOGY OF AGING (2018)

添加到收藏夹

Article Clinical Neurology

Vitamin D for the treatment of multiple sclerosis: a meta-analysis

Laurie McLaughlin et al.

JOURNAL OF NEUROLOGY (2018)

添加到收藏夹

Article Clinical Neurology

Integrating genome-wide association studies and gene expression data highlights dysregulated multiple sclerosis risk pathways

Guiyou Liu et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

添加到收藏夹

Article Clinical Neurology

Integrating genome-wide association studies and gene expression data highlights dysregulated multiple sclerosis risk pathways

Guiyou Liu et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

添加到收藏夹

Article Public, Environmental & Occupational Health

Interpreting findings from Mendelian randomization using the MR-Egger method

Stephen Burgess et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2017)

添加到收藏夹

Article Public, Environmental & Occupational Health

MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data

Olena O. Yavorska et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2017)

添加到收藏夹

Article Medicine, General & Internal

Association of Genetic Variants Related to Serum Calcium Levels With Coronary Artery Disease and Myocardial Infarction

Susanna C. Larsson et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

添加到收藏夹

Article Medicine, General & Internal

Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease

Connor A. Emdin et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

添加到收藏夹

Article Genetics & Heredity

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

Katrina M. de lange et al.

NATURE GENETICS (2017)

添加到收藏夹

Article Clinical Neurology

Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS

Milena A. Gianfrancesco et al.

NEUROLOGY (2017)

添加到收藏夹

Article Clinical Neurology

25-Hydroxyvitamin D deficiency and risk of MS among women in the Finnish Maternity Cohort

Kassandra L. Munger et al.

NEUROLOGY (2017)

添加到收藏夹

Article Genetics & Heredity

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

Jack Bowden et al.

GENETIC EPIDEMIOLOGY (2016)

添加到收藏夹

Article Clinical Neurology

Calcium supplementation and risk of dementia in women with cerebrovascular disease

Jurgen Kern et al.

NEUROLOGY (2016)

添加到收藏夹

Article Genetics & Heredity

Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk

Brooke Rhead et al.

NEUROLOGY-GENETICS (2016)

添加到收藏夹

Article Multidisciplinary Sciences

A Multivariate Genome-Wide Association Analysis of 10 LDL Subfractions, and Their Response to Statin Treatment, in 1868 Caucasians

Heejung Shim et al.

PLOS ONE (2015)

添加到收藏夹

Article Medicine, General & Internal

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study

Lauren E. Mokry et al.

PLOS MEDICINE (2015)

添加到收藏夹

Article Public, Environmental & Occupational Health

Calculating statistical power in Mendelian randomization studies

Marie-Jo A. Brion et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2013)

添加到收藏夹

Article Genetics & Heredity

Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations

Conall M. O'Seaghdha et al.

PLOS GENETICS (2013)

添加到收藏夹

Article Clinical Neurology

Vitamin D as a protective factor in multiple sclerosis

Jonatan Salzer et al.

NEUROLOGY (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

Lucas D. Ward et al.

NUCLEIC ACIDS RESEARCH (2012)

添加到收藏夹

Article Health Care Sciences & Services

Using multiple genetic variants as instrumental variables for modifiable risk factors

Tom M. Palmer et al.

STATISTICAL METHODS IN MEDICAL RESEARCH (2012)

添加到收藏夹

Article Public, Environmental & Occupational Health

Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants

Brandon L. Pierce et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2011)

添加到收藏夹

Article Public, Environmental & Occupational Health

Avoiding bias from weak instruments in Mendelian randomization studies

Stephen Burgess et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2011)

添加到收藏夹

Article Endocrinology & Metabolism

The Risk of Fracture in Patients With Multiple Sclerosis: The UK General Practice Research Database

Marloes T. Bazelier et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2011)

添加到收藏夹

Article Medicine, General & Internal

Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis

Kassandra L. Munger et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)

添加到收藏夹

Article Medicine, General & Internal

Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake

L Steingrimsdottir et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)

添加到收藏夹

Article Clinical Neurology

Vitamin D intake and incidence of multiple sclerosis

KL Munger et al.

NEUROLOGY (2004)

添加到收藏夹

Causal association of genetically determined circulating vitamin D metabolites and calcium with multiple sclerosis in participants of European descent

相关参考文献

导出引文

分享论文