期刊
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
卷 58, 期 8, 页码 S80-S88出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JOM.0000000000000770
关键词
-
资金
- Department of Defense [306889-1.00-64239]
- NIEHS [P30 ES019776]
Objective: The aim of this study was to test the utility of high-resolution metabolomics (HRM) for analysis of nutritional status and health indicators in military personnel. Methods: Serum samples from 400 military personnel were obtained from the Department of Defense Serum Repository (DoDSR) and analyzed for metabolites related to nutrition and health status. Metabolic profile organization was studied using modulated modularity clustering (MMC). Results: HRM provided quantitative measures of 61 metabolites across chemical classes for use as nutritional and clinical biomarkers. Levels were comparable to reported values except for arginine and glutamine, which were above and below reference ranges, respectively. MMC generated five clusters, three of which were associated and contained amino acids. The others contained lipids and mitochondria-related metabolites. Conclusions: HRM analysis of serum is suitable for real-time and/or retrospective evaluation of nutrition and health status of specific military cohorts.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据