Occurrence and removal of psychiatric pharmaceuticals in the Tehran South Municipal Wastewater Treatment Plant

Psychiatric drugs released by humans in wastewater have received more attention because of their potential risks for aquatic organisms. In this study, the occurrence of the two most common groups of psychiatric drugs (sedatives-hypnotics-anxiolytics and antidepressants) were evaluated in the Tehran South Municipal Wastewater Treatment Plant. All the target sedatives-hypnotics-anxiolytics (alprazolam, phenobarbital, and thioridazine) and antidepressants (fluoxetine, citalopram, sertraline, and venlafaxine) were observed in influent and secondary clarification (SC) effluent. Thioridazine (164.25 +/- 218.74 ng/L) and citalopram (672.53 +/- 938.56 ng/L) had the highest mean concentrations in the influent, while alprazolam (5.09 +/- 2.33 ng/L) and citalopram (776.97 +/- 1088.01 ng/L) had the highest concentrations in the SC effluent. The higher concentrations of the psychiatric drugs, except thioridazine, were detected in the SC effluent compared to the concentrations in the influent. The increased drugs concentrations, with negative removal efficiencies, were more distinctive in the cold season samples. Psychiatric drugs processed in the chlorination unit followed a completely different pattern compared to the drugs in the biological treatment unit. All the drugs' concentrations, except thioridazine, decreased in the chlorination unit, ranging between 27 +/- 14% for alprazolam and 75 +/- 10% for citalopram. However, the mean concentrations of the detected drugs were as follows: sertraline (11.96 +/- 11.62 ng/L) and venlafaxine (184.94 +/- 219.74 ng/L) which could cause environmental and ecological concerns.

Automated summary

This study evaluated the occurrence of psychiatric drugs in a wastewater treatment plant in Tehran, and found that their concentrations varied during the treatment process, potentially posing risks to the environment and ecology.