4.7 Article

Childhood urinary organophosphate esters and cognitive abilities in a longitudinal cohort study

期刊

ENVIRONMENTAL RESEARCH
卷 215, 期 -, 页码 -

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2022.114265

关键词

Organophosphate esters; Children; Intelligence; Diphenyl-phosphate; Cohort

资金

  1. National Institute of Environmental Health Sciences
  2. US Environmental Protection Agency [NIEHS F30 ES033086, P01 ES011261, R01 ES014575, R01 ES020349, R01 ES027224, R01 ES028277, EPA P01 R829389]
  3. University of Cincinnati Medical Scientist Training Program [2T32GM063483-1]
  4. L.B. Research and Education Foundation

向作者/读者索取更多资源

The use of organophosphate esters as flame retardants may have adverse effects on cognitive abilities in children, with socioeconomic status influencing the relationship.
The use of organophosphate esters (OPEs) as flame retardants, which has increased over the past two decades, raises concerns that OPEs may be harmful to humans, especially children. Animal studies and some human studies have reported that OPEs may adversely impact brain development, but few human studies evaluated OPE exposure during early childhood and neurodevelopmental outcomes. We aimed to fill this knowledge gap with the present study on urinary OPE metabolite concentrations at ages 1-5 years and cognitive abilities at 8 years. We used data of 223 children from the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort in Cincinnati, Ohio. The point estimates for bis-2-chloroethyl-phosphate (BCEP) and bis(1,3-dichloro-2-propyl)-phosphate (BDCIPP) in association with IQ tended to be small and positive, while the point estimates for diphenyl-phosphate (DPHP) were small and negative, with 95% CIs including the null. However, we did find that socioeconomic status (SES) variables modified associations between OPEs and child IQ, with adverse OPE-IQ associations being stronger in socioeconomically disadvantaged children than in others. We identified an additional 1- to 2-point decrease in Full Scale IQ for every log-unit increase in BDCIPP, BCEP, and DPHP among those with lower maternal education, non-white race, lower income, or living in more deprived neighborhoods. We observed similar results for the Perceptual Reasoning, Verbal Comprehension, and Working Memory Index Scores. We suspect that there is residual confounding related to socioeconomic disadvantage, which was not captured with the available SES variables typically used in epidemiologic studies.

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