期刊
ENVIRONMENTAL RESEARCH
卷 218, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2022.115006
关键词
Gulf of Kachchh; Porites lutea; Antibiotic compound; ADME properties; PHB
The marine ecosystem provides solutions for food, shelter, and pharmaceutical problems, and it plays a crucial role in the country's economy, particularly in tourism. However, the Gulf of Kachchh, known for its high tides and coral reefs, has been less explored for its antibiotic activity due to coral bleaching and diseases. In this study, bacterial strains isolated from the coral Porites lutea showed antibiotic activity against various bacterial strains. The extracted antibiotic compound was identified as 4-[(2E)-4-hydroxypent-2-en-1-yl]-5,6-dihydro-2H-pyran-2-one and was found to have potential as a drug lead with low toxicity and good drug-likeness. The study also investigated the production of Poly Hydroxy Butarate (PHB) by the isolated bacterial strain.
The marine ecosystem contains a solution for food, shelter, pharmaceutical problems and has a key role in the economy of the country as tourism. The Gulf of Kachchh, known for its high tides and the coral reefs are less explored for its antibiotic activity due to the coral bleaching and diseases. The bacterial strains in the coral Porites lutea are determined to possess antibiotic activity against bacterial strains such as E.coli, P. aeruginosa, S. aureus and S. faecalis. Among thirty bacterial strains isolated from the tissue, skeleton and mucus, two bacterial strains resulted in the better antagonistic activity. The antibiotic compound extracted from both the bacteria elucidated to be 4-[(2E)-4-hydroxypent-2-en-1-yl]-5,6-dihydro-2H-pyran-2-one. Further, through ADMET prediction it was inferred that it is an effective drug lead as it reports less toxicity and better drug-likeliness. The study also includes the effect of Poly Hydroxy Butarate (PHB) production by the isolated bacterial strain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据