Occurrence of organophosphorus esters in outdoor air fine particulate matter and comprehensive assessment of human exposure: A global systematic review

Organophosphate esters (OPEs) are widely used in various industrial items, including plastics, textiles, construction materials, electronics, and auto parts. Several studies have investigated the concentration of OPE compounds in the air, where different compounds have been measured. This systematic review aims to investigate and summarize the relationship between exposure concentrations of OPEs in outdoor air and health risk for different OPE compounds, and correlations between OPE compounds in emission sources. PubMed, Scopus, Embase, Web of Science, and Google Scholar were searched from January 2000 to September 2021 to identify relevant research. The quality of the studies was assessed using the OHAT risk of bias tool. Spearman's correlation and principal component analysis (PCA) were used to analyze the results and correlation between OPE compounds. A total of 7669 manuscripts were found from the search in 5 databases. Finally, 46 studies were included in the systematic review. According to the median concentrations in the studies that were included, Tris (1-chloro-2-propyl) phosphate (TCIPP) (25%), trimethylphenyl phosphate(TMPP) (19%), Tri-iso-butyl phosphate (TiBP) (12%), Triphenyl phosphate (TPHP) (9%) and Tris(2-chloroethyl) phosphate (TCEP) (8%) had the greatest concentrations of OPEs overall. The cumulative contribution of the two main factors, F1 and F2, from the principal component analysis (PCA) results is 49.81%. The EDI value for the compounds is TCEP > TCIPP > TiBP > TMPP > 2-Ethylhexyl diphenyl phosphate (EHDPP) > TPHP > Tri(2-Ethylhexyl) phosphate (TEHP) > Tri-mcresyl phosphate (mTCP) > Tris(1, 3-dichloro-isopropyl) phosphate (TDCPP) > Tri-n-butyl phosphate (TnBP). The total amount of non-carcinogenic risk (HQ) was for children > infants > adults. The highest value of HQ was for TCEP, TCIPP, and TMPP, respectively. The highest carcinogenic risk value was for TCEP and TMPP.

Automated summary

This systematic review investigates the relationship between exposure concentrations of organophosphate esters (OPEs) in outdoor air and health risks, as well as correlations between OPE compounds in emission sources. The review identified 46 relevant studies and found that TCIPP, TMPP, TiBP, TPHP, and TCEP had the highest concentrations of OPEs overall. Principal component analysis revealed that F1 and F2 accounted for 49.81% of the cumulative contribution. The EDI values showed that TCEP, TCIPP, and TMPP posed the highest non-carcinogenic risks, and TCEP and TMPP had the highest carcinogenic risk values.