4.7 Article

SAHmap: Synergistic-antagonistic heatmap to evaluate the combined synergistic effect of mixtures of three pesticides on multiple endpoints of Caenorhabditis elegans

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Caenorhabditis elegans provides an efficient drug screening platform for GNAO1-related disorders and highlights the potential role of caffeine in controlling dyskinesia

Martina Di Rocco et al.

Summary: Dominant GNAO1 mutations cause childhood-onset neurological disorders characterized by developmental delay, intellectual disability, movement disorders, drug-resistant seizures, and neurological deterioration. In this study, the functional impact of disease-causing GNAO1 variants was assessed using Caenorhabditis elegans as a model organism. The study found that these variants affect the motor function and neurotransmitter release in the nematodes, and caffeine can partially rescue the abnormality.

HUMAN MOLECULAR GENETICS (2022)

Article Environmental Sciences

Spatiotemporal distribution and risk assessment of organophosphorus pesticides in surface water and groundwater on the North China Plain, China

Jianwei Wang et al.

Summary: A study conducted in the North China Plain found that concentrations of 11 organophosphorus pesticides in groundwater and surface water were higher in summer than in winter. Different types of groundwater sampling points showed different distribution characteristics in the vertical direction, while in the horizontal direction, the concentrations of pesticides in surface water adjacent to farmland were higher than those in nonfarm areas.

ENVIRONMENTAL RESEARCH (2022)

Article Environmental Sciences

Mixture predicted no-effect concentrations derived by independent action model vs concentration addition model based on different species sensitivity distribution models

Ze-Jun Wang et al.

Summary: This study compared the mPNEC values derived by the IA method and the CA method based on SSD models, finding that the mPNEC values obtained by the IA method were generally more conservative, especially for commonly used distribution functions. This provides a new direction for the application of the IA model in risk assessment and enriches the framework of mixture risk assessment.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Environmental Sciences

Combined lethal toxicities of pesticides with similar structures to Caenorhabditis elegans are not necessarily concentration additives

Peng Huang et al.

Summary: This study investigated the mixture toxicity of pesticides with similar chemical structures and found that the interaction types of different types of pesticide mixtures varied, with some showing antagonistic effects and others showing synergistic effects. The structural similarity of pesticides was found to have a quantitative relationship with the toxicity interaction of mixtures, indicating that within a certain range, the structural similarity of the same type of pesticides may exhibit additive action.

ENVIRONMENTAL POLLUTION (2021)

Article Multidisciplinary Sciences

MuSA: a graphical user interface for multi-OMICs data integration in radiogenomic studies

Mario Zanfardino et al.

Summary: Researchers have developed a method to integrate multi-omics data and explore heterogeneity data using MultiAssayExperiment (MAE) and Multi-omics Statistical Approaches (MuSA). The MuSA tool simplifies the management and analysis of radiogenomic datasets, providing an easy-to-use way for researchers. The modular structure of MuSA makes it easily expansible and suitable for guiding non-programmer researchers through various computational steps.

SCIENTIFIC REPORTS (2021)

Article Environmental Sciences

Assessing the combined toxicity of carbamate mixtures as well as organophosphorus mixtures to Caenorhabditis elegans using the locomotion behaviors as endpoints

Yu Wang et al.

Summary: This study systematically evaluated the locomotion behavioral toxicities of carbamate pesticides (CMs) and organophosphorus pesticides (OPs) on Caenorhabditis elegans, and found that they produce significant inhibitory effects on the locomotion behavior of the nematodes, with OPs showing higher toxicity than CMs. Toxicological interactions in the binary CM and OP mixtures were found to be different from each other, highlighting the importance of examining multiple concentration ratios rather than relying on just one.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Chemistry, Multidisciplinary

Study on the Combined Toxicities and Quantitative Characterization of Toxicity Sensitivities of Three Flavor Chemicals and Their Mixtures to Caenorhabditis elegans

Sheng Lu et al.

Summary: This study demonstrated that certain flavor chemicals and their mixture rays have high toxicity sensitivities to Caenorhabditis elegans (C. elegans), which could potentially impact human health. The three flavor chemicals showed significant concentration-response relationships on the lethality of C. elegans, with high toxicity sensitivity. In mixture systems, the toxicity sensitivities of mixture rays with different mixture ratios varied at different exposure volumes, showing complex toxicological interactions.

ACS OMEGA (2021)

Article Environmental Sciences

The use of different sublethal endpoints to monitor atrazine toxicity in nematode Caenorhabditis elegans

Rong Zhou et al.

Summary: The study revealed that the toxic effects of atrazine on Caenorhabditis elegans were concentration-dependent, leading to changes in body length, lifespan, intestinal ROS levels, locomotion behavior, and brood size. Additionally, atrazine may influence the biological activities of nematodes by modulating the mtUPR pathway.

CHEMOSPHERE (2021)

Article Environmental Sciences

Status of pesticide residues in water, sediment, and fishes of Chilika Lake, India

Subir K. Nag et al.

ENVIRONMENTAL MONITORING AND ASSESSMENT (2020)

Article Environmental Sciences

Genetically modified Caenorhabditis elegans may lead to inaccurate toxicity evaluation of mixtures

Peng Huang et al.

ENVIRONMENTAL SCIENCES EUROPE (2020)

Article Environmental Sciences

Individual and mixture toxicity of carbofuran and diuron to the protozoan Paramecium caudatum and the cladoceran Ceriodaphnia silvestrii

Adrislaine S. Mansano et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2020)

Article Environmental Sciences

Analysis of transcriptomic differences between NK603 maize and near-isogenic varieties using RNA sequencing and RT-qPCR

Sina-Elisabeth Ben Ali et al.

ENVIRONMENTAL SCIENCES EUROPE (2020)

Article Environmental Sciences

Intergenerational reproductive toxicity of chlordecone in male Caenorhabditis elegans

Shuhao Dai et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2019)

Article Environmental Sciences

The USA lags behind other agricultural nations in banning harmful pesticides

Nathan Donley

ENVIRONMENTAL HEALTH (2019)

Article Engineering, Environmental

Caenorhabditis elegans As a Promising Alternative Model for Environmental Chemical Mixture Effect Assessment-A Comparative Study

Paul Wittkowski et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2019)

Article Biotechnology & Applied Microbiology

Oxidative stress response, epigenetic and behavioral alterations in Caenorhabditis elegans exposed to organophosphorus pesticide quinalphos

Duraipandian Govindarajan et al.

BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY (2019)

Article Environmental Sciences

Mixture effects in samples of multiple contaminants - An inter-laboratory study with manifold bioassays

Rolf Altenburger et al.

ENVIRONMENT INTERNATIONAL (2018)

Review Toxicology

The C-elegans model in toxicity testing

Piper Reid Hunt

JOURNAL OF APPLIED TOXICOLOGY (2017)

Article Environmental Sciences

Combined toxicity of imidacloprid and three insecticides to the earthworm, Eisenia fetida (Annelida, Oligochaeta)

Tao Cang et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2017)

Article Engineering, Environmental

Interactive toxicity of Ni, Zn, Cu, and Cd on Daphnia magna at lethal and sub-lethal concentrations

Ebrahim Lari et al.

JOURNAL OF HAZARDOUS MATERIALS (2017)

Article Environmental Sciences

Towards a better pesticide policy for the European Union

Veronika Storck et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2017)

Review Medicine, Research & Experimental

Carbamates pesticides induced immunotoxicity and carcinogenicity in human: A review

Ines Bini Dhouib et al.

JOURNAL OF APPLIED BIOMEDICINE (2016)

Article Biochemical Research Methods

A novel method for automated tracking and quantification of adult zebrafish behaviour during anxiety

Shubham Nema et al.

JOURNAL OF NEUROSCIENCE METHODS (2016)

Article Multidisciplinary Sciences

Uniform design ray in the assessment of combined toxicities of multi-component mixtures

Shu-Shen Liu et al.

SCIENCE BULLETIN (2016)

Review Environmental Sciences

Neonicotinoid contamination of global surface waters and associated risk to aquatic invertebrates: A review

Christy A. Morrissey et al.

ENVIRONMENT INTERNATIONAL (2015)

Article Environmental Sciences

Modeling non-monotonic dose-response relationships: Model evaluation and hormetic quantities exploration

Xiang-Wei Zhu et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2013)

Review Biodiversity Conservation

REVIEW: An overview of the environmental risks posed by neonicotinoid insecticides

Dave Goulson

JOURNAL OF APPLIED ECOLOGY (2013)

Article Environmental Sciences

A novel direct equipartition ray design (EquRay) procedure for toxicity interaction between ionic liquid and dichlorvos

Rong-Ni Dou et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2011)

Article Biochemistry & Molecular Biology

Endocrine disruption and altered biochemical indices in male Oncorhynchus mykiss in response to dimethoate

Demet Dogan et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2011)

Article Agronomy

Evaluation of the combined toxicity of 15 pesticides by uniform design

Ya-Hui Zhang et al.

PEST MANAGEMENT SCIENCE (2010)

Article Environmental Sciences

Prediction for the mixture toxicity of six organophosphorus pesticides to the luminescent bacterium Q67

Ya-Hui Zhang et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2008)

Article Biochemistry & Molecular Biology

WormBook: the online review of Caenorhabditis elegans biology

Lisa R. Girard et al.

NUCLEIC ACIDS RESEARCH (2007)

Article Environmental Sciences

Acute toxicity of dichlorvos (DDVP) to fingerling mirror carp, Cyprinus carpio L.

MS Ural et al.

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY (2005)

Article Pharmacology & Pharmacy

The nematode Caenorhabditis elegans as a model of organophosphate-induced mammalian neurotoxicity

RD Cole et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2004)

Article Environmental Sciences

Predictability of the toxicity of a multiple mixture of dissimilarly acting chemicals to Vibrio fischeri

T Backhaus et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2000)