期刊
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
卷 45, 期 7, 页码 4193-4202出版社
SPRINGER
DOI: 10.1007/s10653-022-01438-y
关键词
Polycyclic aromatic hydrocarbon; Liver function; Urinary PAH; PAH metabolites; Gamma-glutamyl transferase
This study aims to examine the association between urinary polycyclic aromatic hydrocarbons (PAHs) and liver function parameters among the US population. Data from the National Health and Nutritional Examination Survey (NHANES) 2003-2016 were used, and a total of 2515 participants were included. Logistic regression analysis showed that increased 9-hydroxyfluorene was associated with elevated GGT levels. In conclusion, 9-hydroxyfluorene is associated with elevated GGT levels, and its effect is modified by other PAHs.
Most studies have focused on the pulmonary toxicity of inhaled PAHs to date; therefore, their hepatotoxic consequences are yet unknown. The main aim of this study is to examine the association between urinary polycyclic aromatic hydrocarbons (PAHs) and liver function parameters among the US population. The data included in this study were from the National Health and Nutritional Examination Survey (NHANES) 2003-2016. Finally, we included 2515 participants from seven cycles of the NHANES. Logistic regression was performed to calculate the association between each PAH and liver function parameters (elevated vs. normal) with odds ratio (OR) and 95% confidence intervals (CIs), along with adjustment for confounding variables. P < 0.05 was considered to indicate a statistically significant difference. All analyses were performed using R software 4.0.1. In the present study, all 2515 individuals were aged >= 18 years, 1211 males, and 1304 females. The average age normal was 45.56 +/- 20.20, and the elevated was 46.04 +/- 19.73 years, respectively. The results of logistic regression indicated that increased 9-hydroxyfluorene (OR = 2.11, 95% CI = [1.52, 2.95], P < 0.001), 2-hydroxyfluorene (OR = 1.61, 95% CI = [1.23, 2.11], P < 0.001), and 3-hydroxyfluorene (OR = 1.54, 95% CI = [1.21, 1.95], P < 0.001) were associated with elevated GGT. In conclusion, 9-hydroxyfluorene is associated with elevated GGT level, and the effect of 9-hydroxyfluorene on GGT is modified by other PAHs, which means that 9-hydroxyfluorene has a greater influence on GGT when other PAHs are increased.
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