4.8 Article

Total oxidizable precursors assay for PFAS in human serum

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Engineering, Environmental

Stability of Per- and Polyfluoroalkyl Substances in Solvents Relevant to Environmental and Toxicological Analysis

Chuhui Zhang et al.

Summary: This study investigated the stability of PFASs, including PFEAs, in different solvents. The results showed that PFEAs degraded in polar aprotic solvents, with degradation rate increasing with temperature and decreasing water-to-organic solvent ratio. Monoethers with a carboxylic acid functional group adjacent to a tertiary carbon degraded more rapidly than those adjacent to repeating-CF2O-groups. On the other hand, monoethers adjacent to a secondary carbon were stable in all tested solvents. High-resolution mass spectrometry revealed the stoichiometric decarboxylation of PFEAs in aprotic solvents, forming products with modified functional groups.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022)

Article Engineering, Environmental

Long-Term Trends of Per- and Polyfluoroalkyl Substances (PFAS) in Suspended Particular Matter from German Rivers Using the Direct Total Oxidizable Precursor (dTOP) Assay

Bernd Goeckener et al.

Summary: Retrospective investigation of suspended particulate matter (SPM) from 13 riverine sampling sites in the German Environmental Specimen Bank collected between 2005 and 2019 revealed the presence of substantial amounts of unknown per- and polyfluoroalkyl substances (PFAS) precursors. Conventional target analysis overestimated actual PFAS concentration decreases, highlighting the importance of considering precursors in environmental assessments. The dTOP assay proved to be a suitable tool for detecting unknown PFAS precursors in the samples.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022)

Article Food Science & Technology

Risk assessment of consumer spray products using in vitro lung surfactant function inhibition, exposure modelling and chemical analysis

J. B. Sorli et al.

Summary: This study focused on assessing the inhibition of lung surfactant function by spray products, with most impregnation products inhibiting function at lower aerosolization rates, while only two cleaning products inhibiting at the highest rates.

FOOD AND CHEMICAL TOXICOLOGY (2022)

Review Environmental Sciences

Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research

Suzanne E. Fenton et al.

Summary: Reports on the impacts of per- and polyfluoroalkyl substances (PFAS) on the environment and human health have increased substantially in peer-reviewed literature. Epidemiological studies have shown associations between exposure to specific PFAS and various health effects, and further research is needed to understand differences in responses between sexes, species, and life stages. More contemporary approaches such as read-across, molecular dynamics, and protein modeling are proposed to accelerate the development of toxicity information on PFAS, as well as the need for precaution to protect human health given the known effects of certain PFAS compounds.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2021)

Article Oncology

Serum Concentrations of Per- and Polyfluoroalkyl Substances and Risk of Renal Cell Carcinoma

Joseph J. Shearer et al.

Summary: The study found a positive association between PFOA and RCC risk, with the association remaining even after adjustment for other PFAS, providing further evidence that PFOA is a renal carcinogen.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2021)

Article Engineering, Environmental

Legacy and emerging per- and polyfluoroalkyl substances (PFASs) in Dagang Oilfield: Multimedia distribution and contributions of unknown precursors

Yue Meng et al.

Summary: The study conducted in Dagang Oilfield, Tianjin, China, revealed that PFASs were widespread and correlated with TPH levels, with C4 and C8 precursors showing a positive correlation with TPH levels, while C6 precursors may come from other sources. Further research is needed to clarify the mass balance and risk assessment of unknown PFASs.

JOURNAL OF HAZARDOUS MATERIALS (2021)

Article Environmental Sciences

Hydrolysis of FTOH precursors, a simple method to account for some of the unknown

Vladimir A. Nikiforov

Summary: This study focuses on the suspected presence of unknown PFAS in consumer goods and the environment, proposing hydrolysis of precursors as a complementary method for explaining the unknown PFAS. The research shows that hydrolysis can preserve structural information on perfluorinated parts of the precursors and detect hidden FTOHs in textile samples up to 1300-fold higher levels.

CHEMOSPHERE (2021)

Review Environmental Sciences

Biotransformation of perfluoroalkyl acid precursors from various environmental systems: advances and perspectives

Wenping Zhang et al.

Summary: Perfluoroalkyl acids (PFAAs) are widely used due to their unique physicochemical properties, but they are environmentally persistent, toxic, and bioaccumulative. Exposure to PFAAs may arise from direct emission or via the environmental release and degradation of PFAA precursors. Studies on the biotransformation of PFAA precursors have shown that it involves the cleavage of carbon-fluorine bonds and degradation of functional groups.

ENVIRONMENTAL POLLUTION (2021)

Article Engineering, Environmental

Near-Quantitative Defluorination of Perfluorinated and Fluorotelomer Carboxylates and Sulfonates with Integrated Oxidation and Reduction

Zekun Liu et al.

Summary: The study demonstrates an efficient method for defluorination of perfluorinated organic compounds through integrated oxidative and reductive treatment, which has the potential to advance remediation technology design and water sample analysis.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2021)

Article Environmental Sciences

Exploring unknown per- and polyfluoroalkyl substances in the German environment - The total oxidizable precursor assay as helpful tool in research and regulation

Bernd Goeckener et al.

Summary: The study analyzed PFAS in Limnetic, marine, and soil samples from the German environmental specimen bank, finding higher concentrations in bream liver and bream fillet, with some regions showing significant contamination. PFOS was the dominant PFAS in most samples, with decreasing trends observed since 2005. The direct TOP assay revealed substantial amounts of PFAS precursors in riverine samples, especially in certain areas along the Upper Elbe and Rhine rivers.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Engineering, Environmental

Enhanced Extraction of AFFF-Associated PFASs from Source Zone Soils

Anastasia Nickerson et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2020)

Article Engineering, Environmental

Solvent Suitability for HFPO-DA (GenX Parent Acid) in Toxicological Studies

Hannah K. Liberatore et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS (2020)

Article Chemistry, Analytical

An overview of the uses of per- and polyfluoroalkyl substances (PFAS)

Juliane Gluege et al.

ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS (2020)

Article Chemistry, Analytical

Advanced PFAS precursor digestion methods for biosolids

Samuel Hutchinson et al.

ENVIRONMENTAL CHEMISTRY (2020)

Article Engineering, Environmental

Fate of Per- and Polyfluoroalkyl Ether Acids in the Total Oxidizable Precursor Assay and Implications for the Analysis of Impacted Water

Chuhui Zhang et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS (2019)

Review Environmental Sciences

A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects

Elsie M. Sunderland et al.

JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY (2019)

Article Engineering, Environmental

Integrating total oxidizable precursor assay data to evaluate fate and transport of PFASs

Rachael Casson et al.

REMEDIATION-THE JOURNAL OF ENVIRONMENTAL CLEANUP COSTS TECHNOLOGIES & TECHNIQUES (2018)

Review Environmental Sciences

BIOTRANSFORMATION PATHWAYS OF FLUOROTELOMER-BASED POLYFLUOROALKYL SUBSTANCES: A REVIEW

Craig M. Butt et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2014)

Article Environmental Sciences

Biotransformation of fluorotelomer compound to perfluorocarboxylates in humans

Helena Nilsson et al.

ENVIRONMENT INTERNATIONAL (2013)

Article Environmental Sciences

Perfluorooctanoic Acid (PFOA) Exposures and Incident Cancers among Adults Living Near a Chemical Plant

Vaughn Barry et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2013)

Article Engineering, Environmental

Persistence of Perfluoroalkyl Acid Precursors in AFFF-Impacted Groundwater and Soil

Erika F. Houtz et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2013)

Article Environmental Sciences

Thyroid Function and Perfluoroalkyl Acids in Children Living Near a Chemical Plant

Maria-Jose Lopez-Espinosa et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2012)

Article Engineering, Environmental

Oxidative Conversion as a Means of Detecting Precursors to Perfluoroalkyl Acids in Urban Runoff

Erika F. Houtz et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2012)

Article Engineering, Environmental

Compound-specific, quantitative characterization of organic: Fluorochemicals in biological matrices

KJ Hansen et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2001)