期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 30, 期 -, 页码 133-142出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2015.11.014
关键词
6-Hydroxydopamine; Neurorescue; Neurorestoration; Docosahexaenoic acid; Dopamine; Parkinson's disease
资金
- Canadian Institutes of Health Research (CIHR)
- Fonds de recherche du Quebec en sante (FRQS)
- Parkinson Society Canada
- CIHR
- FRQS
- Huntington Society of America
- CIHR-Huntington Society of Canada
- Frederic Banting and Charles Best CIHR doctoral award
- Fonds d'Enseignement et de Recherche of the Faculty of Pharmacy of Laval University
Pre-clinical data collected in mouse models of Parkinson's disease (PD) support the neuroprotective potential of omega-3 polyunsaturated fatty acids (n-3 PUFA)enriched diet on the dopaminergic (DAergic) system. In this study, we investigated the effects of an n-3 PUFA-rich diet using a neurorescue/neurorestorative paradigm. C57BL/6 adult mice were submitted to a striatal stereotaxic injection of the neurotoxin 6-hydroxydopamine (6-OHDA) to induce striatal DAergic denervation and subsequent nigral DAergic cell loss. Three weeks post-lesion, mice received either a docosahexaenoic acid (DHA)-enriched or a control diet for a period of 6 weeks. HPLC analyses revealed a 111% post-lesion increase in striatal dopamine levels in the DHA-fed animals compared to controls (ctrl, P<0.05), although no improvement in the motor behavior was observed. DHA treatment led to a 89% rise in tyrosine-hydroxylase (TH)-immunoreactive terminals within the striatum (P<0.05) in lesioned animals. Despite the fact that DHA did not change the number of TH+ neurons in the substantia nigra pars compacta (SNpc), morphological analyses revealed an increased in perimeters (+7%) and areas (+21%) of DAergic cell bodies in treated animals. Collectively, our results suggest that DHA induces a partial neurorescue/neurorestoration of the DAergic system and support further studies to investigate the potential of a diet-based intervention, or at least the combination of such approach, to current treatments in PD. (C) 2015 Elsevier Inc. All rights reserved.
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