4.7 Article

Partial neurorescue effects of DHA following a 6-OHDA lesion of the mouse dopaminergic system

期刊

JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 30, 期 -, 页码 133-142

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2015.11.014

关键词

6-Hydroxydopamine; Neurorescue; Neurorestoration; Docosahexaenoic acid; Dopamine; Parkinson's disease

资金

  1. Canadian Institutes of Health Research (CIHR)
  2. Fonds de recherche du Quebec en sante (FRQS)
  3. Parkinson Society Canada
  4. CIHR
  5. FRQS
  6. Huntington Society of America
  7. CIHR-Huntington Society of Canada
  8. Frederic Banting and Charles Best CIHR doctoral award
  9. Fonds d'Enseignement et de Recherche of the Faculty of Pharmacy of Laval University

向作者/读者索取更多资源

Pre-clinical data collected in mouse models of Parkinson's disease (PD) support the neuroprotective potential of omega-3 polyunsaturated fatty acids (n-3 PUFA)enriched diet on the dopaminergic (DAergic) system. In this study, we investigated the effects of an n-3 PUFA-rich diet using a neurorescue/neurorestorative paradigm. C57BL/6 adult mice were submitted to a striatal stereotaxic injection of the neurotoxin 6-hydroxydopamine (6-OHDA) to induce striatal DAergic denervation and subsequent nigral DAergic cell loss. Three weeks post-lesion, mice received either a docosahexaenoic acid (DHA)-enriched or a control diet for a period of 6 weeks. HPLC analyses revealed a 111% post-lesion increase in striatal dopamine levels in the DHA-fed animals compared to controls (ctrl, P<0.05), although no improvement in the motor behavior was observed. DHA treatment led to a 89% rise in tyrosine-hydroxylase (TH)-immunoreactive terminals within the striatum (P<0.05) in lesioned animals. Despite the fact that DHA did not change the number of TH+ neurons in the substantia nigra pars compacta (SNpc), morphological analyses revealed an increased in perimeters (+7%) and areas (+21%) of DAergic cell bodies in treated animals. Collectively, our results suggest that DHA induces a partial neurorescue/neurorestoration of the DAergic system and support further studies to investigate the potential of a diet-based intervention, or at least the combination of such approach, to current treatments in PD. (C) 2015 Elsevier Inc. All rights reserved.

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