期刊
JOURNAL OF NUTRITION HEALTH & AGING
卷 21, 期 7, 页码 843-848出版社
SPRINGER FRANCE
DOI: 10.1007/s12603-016-0843-6
关键词
Falls; fracture; mortality; muscle mass; muscle strength; sarcopenia
资金
- National Health and Medical Research Council of Australia
- Arthritis Foundation of Australia
- Royal Hobart Hospital Research Foundation
- Tasmanian Community Fund
- University of Tasmania
Objectives: Purpose: To compare the performance of low muscle mass and function with falls risk, incident fracture and mortality over 10 years. Methods: 1041 participants (50% women; mean age 63 +/- 7.5 years) were prospectively followed for 10 years. Falls risk was measured using the Physiological Profile Assessment, fractures were self-reported and mortality was ascertained from the death registry. Appendicular lean mass (ALM) was assessed using dual energy X-ray absorptiometry. Four anthropometric: (ALM/height(2), ALM/body mass index, ALM/weightx100, a residuals method of ALM on height and total body fat) and four performance-based measures: (handgrip strength, lower-limb muscle strength, upper and lower-limb muscle quality) were examined. Participants in the lowest 20% of the sex-specific distribution for each anthropometric and performance-based measure were classified has having low muscle mass or function. Regression analyses were used to estimate associations between each anthropometric and performance-based measure at baseline and 10-year falls risk, incident fractures and mortality. Results: Mean falls risk z-score at 10 years was 0.64 (SD 1.12), incident fractures and mortality over 10 years were 16% and 14% respectively. All baseline performance-based measures were significantly associated with higher falls risk score at 10 years. Low handgrip (RR 1.55, 95% CI: 1.09, 2.20) and ALM/body mass index (RR 1.54, 95% CI: 1.14, 2.08) were the only significant predictors of fracture and mortality respectively. Conclusions: Low handgrip strength, a simple and inexpensive test could be considered in clinical settings for identifying future falls and fractures. ALM/ body mass index could be most suitable in estimating 10-year mortality risk, but requires specialised equipment.
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