4.7 Article

MiR-182-3p targets TRF2 and impairs tumor growth of triple-negative breast cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

miR-490 suppresses telomere maintenance program and associated hallmarks in glioblastoma

Omkar Suhas Vinchure et al.

Summary: miR-490 targets multiple genes to regulate telomere maintenance in GBM, exerting tumor suppressive effects, impacting stemness and senescence, activating DNA damage response, and potentially holding therapeutic significance in GBM treatment.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Pharmacology & Pharmacy

Diagnostic and therapeutic evaluation of folate-targeted paclitaxel and vinorelbine encapsulating theranostic liposomes for non-small cell lung cancer

Merve Karpuz et al.

Summary: This study demonstrates that folate-targeted, co-drug encapsulating liposomal formulations exhibit higher therapeutic and diagnostic efficacy in inhibiting lung cancer tumor growth and preventing lung metastasis. Additionally, liposomal formulations show lower toxicity compared to free drug combinations.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Review Pharmacology & Pharmacy

Evolution of blood-brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies

Liang Han et al.

Summary: This review focuses on nanoscale brain-targeting drug delivery strategies designed based on blood-brain barrier (BBB) alterations and their applications in various brain diseases. However, advances on optimization of small molecules for BBB crossing and non-systemic administration routes such as intranasal treatment are not included in this review.

ACTA PHARMACEUTICA SINICA B (2021)

Review Medicine, General & Internal

Current and future nanoparticle vaccines for COVID-19

Mai N. Vu et al.

Summary: COVID-19 has caused massive health and economic disruptions globally, and mass vaccination is the most efficient way to end the pandemic. Nanoparticle-based vaccines are becoming increasingly important in extending or improving vaccination outcomes against COVID-19, with over 26 candidates in clinical testing and around 60 more in pre-clinical development. The emerging promise of nanotechnology in vaccine design and manufacturing to combat SARS-CoV-2 presents both opportunities and challenges.

EBIOMEDICINE (2021)

Article Biotechnology & Applied Microbiology

Noncoding RNA therapeutics - challenges and potential solutions

Melanie Winkle et al.

Summary: In recent years, RNA-based therapies have gained FDA approval, but there are still challenges in targeting ncRNAs. Therapeutic targeting of noncoding RNAs has the potential to become a new approach for treating diseases such as cancer.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Oncology

A Novel Screen for Expression Regulators of the Telomeric Protein TRF2 Identified Small Molecules That Impair TRF2 Dependent Immunosuppression and Tumor Growth

Mounir El Mai et al.

Summary: TRF2, upregulated in human cancers, plays a crucial role in both telomere protection and extrinsic effects like angiogenesis and immunosuppression. Two compounds identified through a cell-based screening method, AR-A014418 and alexidine center dot 2HCl, were found to inhibit TRF2's pro-oncogenic properties in vivo. This highlights the potential therapeutic strategy of targeting TRF2 in aggressive tumors.

CANCERS (2021)

Review Pharmacology & Pharmacy

Recent Advances in Liposomal-Based Anti-Inflammatory Therapy

Carla M. A. van Alem et al.

Summary: Liposomes are considered ideal carriers for anti-inflammatory drugs due to their ability to target sites of inflammation and increase local efficacy. However, clinical translation of liposomal nanomedicines in the field of inflammatory diseases still poses challenges. Recent research has focused on innovations and cutting-edge developments in liposomal treatment.

PHARMACEUTICS (2021)

Review Biochemistry & Molecular Biology

Shelterin complex gene: Prognosis and therapeutic vulnerability in cancer

Vikas Kumar Bhari et al.

Summary: Telomeres consist of (TTAGGG)n tandem repeats that play a crucial role in stabilizing chromosomes and protecting them from fusion and DNA degradation. Regulated by key players such as shelterin complex genes and telomerase, targeting these regulators can combat cancer as telomere length is linked to cancer initiation and progression. The study focuses on the role of telomere length regulators in breast cancer prognosis and drug targets, as well as the correlation of shelterin complex genes with breast cancer prognosis.

BIOCHEMISTRY AND BIOPHYSICS REPORTS (2021)

Review Biochemistry & Molecular Biology

Potential miRNAs for miRNA-Based Therapeutics in Breast Cancer

Jun Sheng Wong et al.

NON-CODING RNA (2020)

Article Biochemistry & Molecular Biology

TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment

Pasquale Zizza et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Multidisciplinary Sciences

SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability

Eleonora Petti et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2

Julien Cherfils-Vicini et al.

EMBO JOURNAL (2019)

Article Medicine, Research & Experimental

Multiple cancer pathways regulate telomere protection

Leire Bejarano et al.

EMBO MOLECULAR MEDICINE (2019)

Article Nanoscience & Nanotechnology

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akin Akinc et al.

NATURE NANOTECHNOLOGY (2019)

Article Medicine, General & Internal

MiR-182-5p Knockdown Targeting PTEN Inhibits Cell Proliferation and Invasion of Breast Cancer Cells

Yue-Sheng Zhao et al.

YONSEI MEDICAL JOURNAL (2019)

Correction Oncology

miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a (vol 11, 12, 2018)

Man-Qing Cao et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Article Biochemistry & Molecular Biology

Genome-wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2

Aaron Mendez-Bermudez et al.

MOLECULAR CELL (2018)

Review Genetics & Heredity

Shelterin-Mediated Telomere Protection

Titia de Lange

ANNUAL REVIEW OF GENETICS, VOL 52 (2018)

Review Endocrinology & Metabolism

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

Jacob O'Brien et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Article Chemistry, Physical

Synthesis and characterization of PEGylated bolaamphiphiles with enhanced retention in liposomes

Yingyue Zhang et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2016)

Review Oncology

Patient-derived xenografts: a relevant preclinical model for drug development

Luca Pompili et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2016)

Article Multidisciplinary Sciences

High expression of microRNA-183/182/96 cluster as a prognostic biomarker for breast cancer

Cailu Song et al.

SCIENTIFIC REPORTS (2016)

Article Medicine, Research & Experimental

Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage

Maria Garcia-Beccaria et al.

EMBO MOLECULAR MEDICINE (2015)

Article Oncology

MicroRNA-183/182/96 cooperatively regulates the proliferation of colon cancer cells

Qingquan Zhang et al.

MOLECULAR MEDICINE REPORTS (2015)

Article Oncology

TRF2 acts as a transcriptional regulator in tumor angiogenesis

Mounir El Mai et al.

MOLECULAR & CELLULAR ONCOLOGY (2015)

Article Oncology

miR-155 Drives Telomere Fragility in Human Breast Cancer by Targeting TRF1

Roberto Dinami et al.

CANCER RESEARCH (2014)

Article Biotechnology & Applied Microbiology

Transferrin-Conjugated SNALPs Encapsulating 2′-O-Methylated miR-34a for the Treatment of Multiple Myeloma

Immacolata Scognamiglio et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Article Biochemistry & Molecular Biology

Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation

Ylli Doksani et al.

Article Multidisciplinary Sciences

A two-step mechanism for TRF2-mediated chromosome-end protection

Keiji Okamoto et al.

NATURE (2013)

Article Pharmacology & Pharmacy

MicroRNA 199b-5p delivery through stable nucleic acid lipid particles (SNALPs) in tumorigenic cell lines

Pasqualino de Antonellis et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2013)

Review Medicine, General & Internal

The Implications of Clonal Genome Evolution for Cancer Medicine

Samuel Aparicio et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Oncology

Elevated TRF2 in advanced breast cancers with short telomeres

Malissa C. Diehl et al.

BREAST CANCER RESEARCH AND TREATMENT (2011)

Review Oncology

Telomerase and cancer therapeutics

Calvin B. Harley

NATURE REVIEWS CANCER (2008)

Article Multidisciplinary Sciences

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

Eros Lazzerini Denchi et al.

NATURE (2007)

Article Cell Biology

Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis

Raquel Blanco et al.

GENES & DEVELOPMENT (2007)

Article Biochemistry & Molecular Biology

Glutathione influences c-Myc-induced apoptosis in M14 human melanoma cells

A Biroccio et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Genetics & Heredity

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis

E González-Suárez et al.

NATURE GENETICS (2000)