Recent research reveals a novel role of PHGDH, an enzyme in the de novo serine synthesis pathway, as a regulator of mitochondrial translation and tumor progression in liver cancer.
How do cancer cells bolster their energy metabolism under conditions of stress? Recent work by Shu et al (2022) unveils a novel, non-canonical function of the de novo serine synthesis pathway enzyme phosphoglycerate dehydrogenase (PHGDH) as a regulator of mitochondrial translation and tumor progression in liver cancer.
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