期刊
EJSO
卷 49, 期 7, 页码 1250-1257出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejso.2023.01.002
关键词
Cystectomy; Bladder preservation; Pelvic exenteration; Rectal cancer
This study compared the treatment outcomes and post-operative complications between partial cystectomy (PC) and radical cystectomy (RC) in patients with locally advanced or recurrent rectal cancer. It found that PC had good oncological outcome in patients with locally advanced rectal cancer, while RC was more suited for recurrent rectal cancer.
Introduction: In patients with locally advanced (LARC) or locally recurrent (LRRC) rectal cancer and bladder involvement, pelvic exenteration (PE) with partial (PC) or radical (RC) cystectomy can potentially offer a cure. The study aim was to compare PC and RC in PE patients in terms of oncological outcome, post-operative complications and quality-of-life (QoL).Materials & methods: This was a retrospective cohort analysis of a prospectively maintained surgical database. Patients who underwent PE for LARC or LRRC cancer with bladder involvement between 1998 and 2021 were included. Post-operative complications and overall survival were compared between patients with PC and RC.Results: 60 PC patients and 269 RC patients were included. Overall R0 resection was 84.3%. Patients with LRRC and PC had poorest oncological outcome with 69% R0 resection; patients with LARC and PC demonstrated highest R0 rate of 96.3% (P = 0.008). Overall, 1-, 3-and 5-year OS was 90.8%, 68.1% and 58.6% after PC, and 88.7%, 62.2% and 49.5% after RC. Rates of urinary sepsis or urological leaks did not differ between groups, however, RC patients experienced significantly higher rates of perineal wound-and flap-related complications (39.8% vs 25.0%, P = 0.032).Conclusion: PC as part of PE can be performed safely with good oncological outcome in patients with LARC. In patients with LRRC, PC results in poor oncological outcome and a more aggressive surgical approach with RC seems justified. The main benefit of PC is a reduction in wound related complications compared to RC, although more urological re-interventions are observed in this group. & COPY; 2023 Elsevier Ltd, BASO -The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
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