4.7 Article

Fluxapyroxad disrupt erythropoiesis in zebrafish (Danio rerio) embryos br

期刊

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2022.114259

关键词

Fluxapyroxad; SDHIs; Zebrafish; Embryo; Hematotoxicity

资金

  1. Fundamental Research Funds for the Central Universities of Huaqiao University
  2. [ZQN-923]

向作者/读者索取更多资源

In this study, the influence of fluxapyroxad on hematopoietic development was evaluated using zebrafish embryos. The results showed that fluxapyroxad treatment led to abnormal distribution and decreased levels of hemoglobin, as well as reduced transcription levels of genes involved in erythropoiesis.
Fluxapyroxad, a succinate dehydrogenase inhibitor (SDHI) fungicide, is commercialized worldwide to control a variety of fungal diseases. Growing evidence shows that fluxapyroxad is teratogenic to aquatic organisms. In this study, the influence of fluxapyroxad toward hematopoietic development was evaluated using zebrafish embryos which were exposed to fluxapyroxad (0.03 mu M, 0.3 mu M and 3 mu M) from 3 h post fertilization (hpf) to 3 days post fertilization (dpf). Compared to the control groups, the hemoglobin was ectopic and decreased in response to fluxapyroxad treatment. The transcription levels of genes (hbbe1, hbbe2, and gata1a) involved in erythropoiesis were reduced after exposure to fluxapyroxad. In contrast, the distributions and expression of marker genes for myeloid lineage cells were unaffected by fluxapyroxad exposure. Our data suggested that fluxapyroxad might specifically affect erythropoiesis and hold great promise for the assessment of the toxicity of fluxapyroxad to aquatic organisms.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据