Adolescence is a sensitive period for acrylamide-induced sex hormone disruption: Evidence from NHANES populations and experimental mice

Review Endocrinology & Metabolism

Membrane-Initiated Estrogen, Androgen, and Progesterone Receptor Signaling in Health and Disease

Franck Mauvais-Jarvis et al.

Summary: Steroid hormones regulate physiological and disease processes through binding to receptors on the cell membrane and collaboration with receptors in the nucleus.

ENDOCRINE REVIEWS (2022)

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Article Food Science & Technology

Gestational exposure to acrylamide suppresses luteal endocrine function through dysregulation of ovarian angiogenesis, oxidative stress and apoptosis in mice

Dainan Yu et al.

Summary: This study found that acrylamide exposure during early- and mid-pregnancy had negative effects on luteal function, including decreased levels of serum progesterone and estradiol, reduced numbers and relative areas of ovarian corpora lutea, dysregulation of ovarian angiogenesis, increased oxidative stress, and induced apoptosis of ovarian cells.

FOOD AND CHEMICAL TOXICOLOGY (2022)

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Article Environmental Sciences

Cancer risk and disease burden of dietary acrylamide exposure in China, 2016

Yiling Li et al.

Summary: This study assessed the exposure to acrylamide in Chinese food and the associated cancer risk and disease burden. The results showed that acrylamide exposure resulted in approximately 23688.09 DALYs of cancer burden among the Chinese population. This highlights the health risks posed by dietary acrylamide exposure and the importance of policy prioritization.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

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Article Food Science & Technology

Paternal acrylamide exposure induces transgenerational effects on sperm parameters and learning capability in mice

Hang Zhang et al.

Summary: This study demonstrates that paternal exposure to AA leads to transgenerational adverse effects on sperm parameters and learning capability in mice through DNA methylation.

FOOD AND CHEMICAL TOXICOLOGY (2022)

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Article Cell Biology

ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota

Sup Kim et al.

Summary: ESRRA plays a critical role in regulating intestinal homeostasis and ameliorating colonic inflammation by activating autophagy pathways and controlling host gut microbiota, protecting the host from detrimental inflammation and dysfunctional mitochondria.

AUTOPHAGY (2021)

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Article Cell Biology

Hypothalamo-Pituitary axis and puberty

Matteo Spaziani et al.

Summary: Puberty is a complex process that involves a delicate balance of neuroendocrine mechanisms and hormones to achieve psychophysical maturity and reproductive capacity. The onset of puberty is triggered by interactions between the hypothalamus, pituitary gland, and gonads, with significant variations between genders and individuals, as well as possible pathological variations such as precocious and delayed puberty.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2021)

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Article Multidisciplinary Sciences

Relationships of sex hormones with muscle mass and muscle strength in male adolescents at different stages of puberty

Yang Xu et al.

Summary: This study found that serum testosterone had different associations with muscle parameters in Chinese early-mid pubertal and late-post pubertal boys. In the late-post pubertal boys, serum testosterone was curvilinearly related to muscle strength with a threshold effect, and its link with muscle mass was weaker.

PLOS ONE (2021)

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Article Environmental Sciences

Association of acrylamide hemoglobin biomarkers with serum lipid levels in general US population: NHANES 2013?2016

Iokfai Cheang et al.

Summary: The study found an association between acrylamide (AA) hemoglobin biomarkers and serum lipid levels, particularly with triglycerides (TG) showing a linear correlation. Additionally, there was a positive correlation between HbGA/HbAA and low-density lipoprotein-cholesterol (LDL-C), and a negative correlation with high-density lipoproteincholesterol (HDL-C).

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

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Article Environmental Sciences

Association of acrylamide and glycidamide haemoglobin adduct levels with diabetes mellitus in the general population

Guangli Yin et al.

Summary: The study found that HbAA was linearly and inversely associated with the risk of DM, while HbGA/HbAA was nonlinearly and positively associated with the prevalence of DM. These results support epidemiological evidence that HbAA and HbGA/HbAA are significantly associated with diabetes mellitus.

ENVIRONMENTAL POLLUTION (2021)

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Article Neurosciences

Sex neurosteroids: Hormones made by the brain for the brain

L. Fester et al.

Summary: Hippocampal neurons have the ability to synthesize sex steroids from cholesterol, with estradiol and testosterone playing important roles in maintaining synaptic transmission and connectivity. The synthesis of these steroids is regulated by internal and external factors, and there are sex-specific differences in how estradiol and dihydrotestosterone affect synaptic functions. The link between GnRH-induced estradiol synthesis and cyclical changes in spine density in the female hippocampus suggests a complex interaction between the hypothalamus and hippocampus in regulating neuronal responses to sex neurosteroids.

NEUROSCIENCE LETTERS (2021)

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Article Environmental Sciences

Bisphenol A substitutes and sex hormones in children and adolescents

Yuqing Wang et al.

Summary: The study found that BPA has adverse effects on sex hormone levels in female adolescents, while the associations with BPF or BPS were more sporadic. In female adolescents, there were U-shaped relationships between BPA, BPF, and BPS with sex hormones. The associations were virtually nonsignificant among males.

CHEMOSPHERE (2021)

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Review Endocrinology & Metabolism

Improving clinical outcomes through attention to sex and hormones in research

Michelle M. Mielke et al.

Summary: Sex differences play a crucial role in research and healthcare, and considering gender and hormonal status in studies can lead to personalized and improved health care. Inclusion of female animals and women in studies is important for developing precise therapeutics. Sex steroid hormones can interact with receptors for drug targets, metabolism and transport, impacting therapeutic efficacy and adverse drug reactions.

NATURE REVIEWS ENDOCRINOLOGY (2021)

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Article Integrative & Complementary Medicine

Portulaca oleracea seeds' extract alleviates acrylamide-induced testicular dysfunction by promoting oxidative status and steroidogenic pathway in rats

Ola M. Farag et al.

Summary: The study suggests that Portulaca oleracea seeds extract has a protective effect against ACR-induced testicular toxicity in rats, improving semen quality, reducing testicular damage, regulating oxidative stress, and inhibiting cell apoptosis.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2021)

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Article Endocrinology & Metabolism

Association between Biomarkers of Low-grade Inflammation and Sex Hormones in Women with Polycystic Ovary Syndrome

Erifili Hatziagelaki et al.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2020)

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Article Environmental Sciences

Associations between organophosphate esters and sex hormones among 6-19-year old children and adolescents in NHANES 2013-2014

Kai Luo et al.

ENVIRONMENT INTERNATIONAL (2020)

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Review Psychiatry

Hormonal Treatments for Major Depressive Disorder: State of the Art

Jennifer B. Dwyer et al.

AMERICAN JOURNAL OF PSYCHIATRY (2020)

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Article Environmental Sciences

Acrylamide impairs ovarian function by promoting apoptosis and affecting reproductive hormone release, steroidogenesis and autophagy-related genes: An in vivo study

Nouf Aldawood et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2020)

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Review Cell Biology

Mathematical modeling approaches of cellular endocrinology within the hypothalamo-pituitary-gonadal axis

Frederique Clement et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2020)

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Article Biochemistry & Molecular Biology

Therapeutic effect of curcumin on acrylamide-induced apoptosis mediated by MAPK signaling pathway in Leydig cells

Nebahat Yildizbayrak et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2019)

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Review Medicine, Research & Experimental

Impact of estrogens in males and androgens in females

Stephen R. Hammes et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Review Chemistry, Applied

Acrylamide: A review about its toxic effects in the light of Developmental Origin of Health and Disease (DOHaD) concept

Viviane Matoso et al.

FOOD CHEMISTRY (2019)

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Article Endocrinology & Metabolism

The hypothalamus-pituitary-gonad axis: Tales of mice and men

Athina Kaprara et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2018)

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Article Environmental Sciences

Exposure to acrylamide and the risk of cardiovascular diseases in the National Health and Nutrition Examination Survey 2003-2006

Yu Zhang et al.

ENVIRONMENT INTERNATIONAL (2018)

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Article Food Science & Technology

Protection of cyanidin-3-O-glucoside against acrylamide- and glycidamide-induced reproductive toxicity in leydig cells

Jianxia Sun et al.

FOOD AND CHEMICAL TOXICOLOGY (2018)

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Article Biochemistry & Molecular Biology

Toxicogenomic evaluation of liver responses induced by acrylamide and glycidamide in male mouse liver

Dongyan Chen et al.

GENERAL PHYSIOLOGY AND BIOPHYSICS (2018)

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Article Endocrinology & Metabolism

Modulation of SHBG binding to testosterone and estradiol by sex and morbid obesity

Maria del Mar Grasa et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2017)

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Article Toxicology

Evidence of acrylamide- and glycidamide-induced oxidative stress and apoptosis in Leydig and Sertoli cells

B. O. Yilmaz et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2017)

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Review Physiology

Acrylamide: a Common Food Toxin Related to Physiological Functions and Health

M. Semla et al.

PHYSIOLOGICAL RESEARCH (2017)

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Article Biochemistry & Molecular Biology

Metabolism of Acrylamide: Interindividual and Interspecies Differences as Well as the Application as Biomarkers

Daotong Li et al.

CURRENT DRUG METABOLISM (2016)

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Review Agriculture, Multidisciplinary

Current issues in dietary acrylamide: formation, mitigation and risk assessment

Franco Pedreschi et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2014)

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Article Oncology

Sex hormones and breast cancer risk and prognosis

Elizabeth Folkerd et al.

BREAST (2013)

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Review Behavioral Sciences

Environmental and social influences on neuroendocrine puberty and behavior in macaques and other nonhuman primates

Shannon B. Z. Stephens et al.

HORMONES AND BEHAVIOR (2013)

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Review Cell Biology

Tissue- and cell-specific functions of the androgen receptor revealed through conditional knockout models in mice

Karel De Gendt et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2012)

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Article Toxicology

Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 rats

L. Camacho et al.

TOXICOLOGY LETTERS (2012)

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Article Multidisciplinary Sciences

The adolescent brain

B. J. Casey et al.

YEAR IN COGNITIVE NEUROSCIENCE 2008 (2008)

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Review Biochemistry & Molecular Biology

Gonadotropin-releasing hormone: regulation of the GnRH gene

Vien H. Y. Lee et al.

FEBS JOURNAL (2008)

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Adolescence is a sensitive period for acrylamide-induced sex hormone disruption: Evidence from NHANES populations and experimental mice

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