TB500/TB1000 and SGF1000: A scientific approach for a better understanding of misbranded and adulterated drugs

Nowadays, numerous websites attempt to commercialize over the internet various products, regardless of the lack of approval by the EMA or the FDA either for human or veterinary use. These products are often produced after aborted drug development due to insufficient or deleterious biological effects, synthesized based on natural products, or only based on scientific literature. However, the administration of such products is dangerous, considering the lack of official control over the production of these substances and the absence of approval by health authorities. In this short communication, we provide an extensive analysis of three misbranded and adulterated products sold over the internet named TB500, TB1000, and SGF1000. We confirm that the content of TB500/TB1000 products is not systematically consistent with it's former descriptions, but also that SGF1000 is mainly composed of sheep extracellular matrix (ECM) and blood proteins, and the signal corresponding to the purported growth promoters is excessively diluted.

Automated summary

Currently, many websites sell products online without approval from EMA or FDA, which may pose risks due to lack of regulation and official approval. In this study, we analyze three misbranded and adulterated products named TB500, TB1000, and SGF1000. Results show that the content of TB500/TB1000 products is inconsistent with their descriptions, and SGF1000 is primarily composed of sheep ECM and blood proteins, with diluted growth promoters.