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Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice
Darrell R. Boverhof et al.
TOXICOLOGICAL SCIENCES (2006)
Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways
M. K. Shelby et al.
DRUG METABOLISM AND DISPOSITION (2006)
Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes
Emilie Jigorel et al.
DRUG METABOLISM AND DISPOSITION (2006)
Regulation of constitutive mouse hepatic cytochromes p450 and growth hormone signaling components by 3-methylcholanthrene
Chunja Lee et al.
DRUG METABOLISM AND DISPOSITION (2006)
The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and-1A2 and NAD(P) H:quinone oxidoreductase
Marie Stiborova et al.
DRUG METABOLISM AND DISPOSITION (2006)
Induction of CYP1A and CYP2-mediated arachidonic acid epoxygenation and suppression of 20-hydroxyeicosatetraenoic acid by imidazole derivatives including the aromatase inhibitor vorozole
Silvia Diani-Moore et al.
DRUG METABOLISM AND DISPOSITION (2006)
Induction of detoxifying enzymes in rodent white adipose tissue by aryl hydrocarbon receptor agonists and antioxidants
Kouichi Yoshinari et al.
DRUG METABOLISM AND DISPOSITION (2006)
Regulation of CYP1A1 gene expression by the antioxidant tert-butylhydroquinone
Thomas D. Schreiber et al.
DRUG METABOLISM AND DISPOSITION (2006)
Profiling the hepatic effects of flutamide in rats: A microarray comparison with classical aryl hydrocarbon receptor ligands and atypical CYP1A inducers
Kevin J. Coe et al.
DRUG METABOLISM AND DISPOSITION (2006)
Demethylation of the pesticide methoxychlor in liver and intestine from untreated, methoxychlor-treated, and 3-methylcholanthrene-treated channel catfish (Ictalurus punctatus):: Evidence for roles of CYP1 and CYP3a family isozymes
Leah D. Stuchal et al.
DRUG METABOLISM AND DISPOSITION (2006)
Cytochrome P450 gene induction in rats ex vivo assessed by quantitative real-time reverse transcriptase-polymerase chain reaction (taqman)
Sandra J. Baldwin et al.
DRUG METABOLISM AND DISPOSITION (2006)
Benzo[A] pyrene-induced oral carcinogenesis and chemoprevention:: Studies in bioengineered human tissue
T Walle et al.
DRUG METABOLISM AND DISPOSITION (2006)
Transcriptional regulation of the NAD(P)H : quinone oxidoreductase 1 and glutathione S-transferase Ya genes by mercury, lead, and copper
HM Korashy et al.
DRUG METABOLISM AND DISPOSITION (2006)
Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells
C Aninat et al.
DRUG METABOLISM AND DISPOSITION (2006)
Simultaneous measurement of 23 isoforms from the human cytochrome p450 families 1 to 3 by quantitative reverse transcriptase-polymerase chain reaction
I Girault et al.
DRUG METABOLISM AND DISPOSITION (2005)
Modulation of human cytochrome P4501B1 expression by 2,4,3′,5′-tetramethoxystilbene
YJ Chun et al.
DRUG METABOLISM AND DISPOSITION (2005)
Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies
EG van de Kerkhof et al.
DRUG METABOLISM AND DISPOSITION (2005)
Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways
XG Cheng et al.
DRUG METABOLISM AND DISPOSITION (2005)
Isoform-specific expression and induction of UDP-glucuronosyltransferase in immunoactivated peritoneal macrophages of the rat
Y Tochigi et al.
DRUG METABOLISM AND DISPOSITION (2005)
Functional analysis of six human aryl hydrocarbon receptor variants in a Japanese population
S Koyano et al.
DRUG METABOLISM AND DISPOSITION (2005)
Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes
D Roymans et al.
DRUG METABOLISM AND DISPOSITION (2005)
The use of a substrate cassette strategy to improve the capacity and throughput of cytochrome P450 induction studies in human hepatocytes
MA Mohutsky et al.
DRUG METABOLISM AND DISPOSITION (2005)
Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liver
JM Maher et al.
DRUG METABOLISM AND DISPOSITION (2005)
Induction of CYP1A in the beagle dog by an inhibitor of kinase insert domain-containing receptor: Differential effects in vitro and in vivo on mRNA and functional activity
CR Gibson et al.
DRUG METABOLISM AND DISPOSITION (2005)
In vivo induction of human cytochrome P450 enzymes expressed in chimeric mice with humanized liver
M Katoh et al.
DRUG METABOLISM AND DISPOSITION (2005)
Metabolism-based drug-drug interactions: What determines individual variability in cytochrome P450 induction?
C Tang et al.
DRUG METABOLISM AND DISPOSITION (2005)
Human cytochrome P4502S1: Lack of activity in the metabolic activation of several cigarette smoke carcinogens and in the metabolism of nicotine
SL Wang et al.
DRUG METABOLISM AND DISPOSITION (2005)
Mechanisms of arsenite-mediated decreases in benzo[k] fluoranthene-induced human cytochrome P4501A1 levels in HepG2 cells
EE Bessette et al.
DRUG METABOLISM AND DISPOSITION (2005)
tert-butylhydroquinone is a novel aryl hydrocarbon receptor ligand
N Gharavi et al.
DRUG METABOLISM AND DISPOSITION (2005)
Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals
DS Riddick et al.
DRUG METABOLISM AND DISPOSITION (2004)
Glucuronidation and the UDP-glucuronosyltransferases in health and disease
PG Wells et al.
DRUG METABOLISM AND DISPOSITION (2004)
Sequential metabolism of 2,3,7-trichlorodibenzo-P-dioxin (2,3,7-triCDD) by cytochrome P450 and UDP-glucuronosyltransferase in human liver microsomes
N Kasai et al.
DRUG METABOLISM AND DISPOSITION (2004)
Fluorinated 2-(4-amino-3-methylphenyl) benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells
E Brantley et al.
DRUG METABOLISM AND DISPOSITION (2004)
An assessment of udp-glucuronosyltransferase induction using primary human hepatocytes
MG Soars et al.
DRUG METABOLISM AND DISPOSITION (2004)
The olivacine derivative S 16020 (9-hydroxy-5,6-dimethyl-N-[2-(dimethylamino)ethyl)-6H-pyrido(4,3-b)-carbazole-1-carboxamide) induces CYP1A and its own metabolism in human hepatocytes in primary culture
L Pichard-Garcia et al.
DRUG METABOLISM AND DISPOSITION (2004)
Assessment of catechol induction and glucuronidation in rat liver microsomes
E Elovaara et al.
DRUG METABOLISM AND DISPOSITION (2004)
Molecular cloning of the guinea pig CYP1A2 gene 5′-flanking region:: Identification of functional aromatic hydrocarbon response element and characterization of CYP1A2 expression in GPC16 cells
VH Black et al.
DRUG METABOLISM AND DISPOSITION (2004)
The small intestine as a xenobiotic-metabolizing organ
LS Kaminsky et al.
DRUG METABOLISM AND DISPOSITION (2003)
Comparison of primary human hepatocytes and hepatoma cell line HEPG2 with regard to their biotransformation properties
S Wilkening et al.
DRUG METABOLISM AND DISPOSITION (2003)
The conduct of in vitro and in vivo drug-drug interaction studies: A Pharmaceutical Research and Manufacturers of America (PhRMA) perspective
TD Bjornsson et al.
DRUG METABOLISM AND DISPOSITION (2003)
Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor
MK Bunger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse
T Moriguchi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes
A Madan et al.
DRUG METABOLISM AND DISPOSITION (2003)
CYP1A1 and CYP1B1 in blood-brain interfaces:: CYP1A1-dependent bioactivation of 7,12-dimethylbenz(a)anthracene in endothelial cells
L Granberg et al.
DRUG METABOLISM AND DISPOSITION (2003)
Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices
RJ Edwards et al.
DRUG METABOLISM AND DISPOSITION (2003)
Characterization of in vitro metabolites of the aryl hydrocarbon receptor ligand 6-formylindolo[3,2-b] carbazole by liquid chromatography-mass spectrometry and NMR.
L Bergander et al.
DRUG METABOLISM AND DISPOSITION (2003)
Characterization of mouse small intestinal cytochrome P450 expression
QY Zhang et al.
DRUG METABOLISM AND DISPOSITION (2003)
The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor
A Joiakim et al.
DRUG METABOLISM AND DISPOSITION (2003)
Suppression of cytochrome P4502C11 by aromatic hydrocarbons:: Mechanistic insights from studies of the 5′-flanking region of the CYP2C11 gene
A Bhathena et al.
DRUG METABOLISM AND DISPOSITION (2002)
In vivo and in vitro induction of cytochrome P450 enzymes in beagle dogs
RA Graham et al.
DRUG METABOLISM AND DISPOSITION (2002)
Tissue distribution and chemical induction of multiple drug resistance genes in rats
JM Brady et al.
DRUG METABOLISM AND DISPOSITION (2002)
Induction of human UDP-glucuronosyltransferase UGT1A1 by flavonoids-structural requirements
UK Walle et al.
DRUG METABOLISM AND DISPOSITION (2002)
Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation
NR Vansell et al.
DRUG METABOLISM AND DISPOSITION (2002)
Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[A]pyrene is diminished by arsenite
DC Spink et al.
DRUG METABOLISM AND DISPOSITION (2002)
Identification of toxicologically predictive gene sets using cDNA microarrays
RS Thomas et al.
MOLECULAR PHARMACOLOGY (2001)
Definition of a dioxin receptor mutant that is a constitutive activator of transcription - Delineation of overlapping repression and ligand binding functions within the PAS domain
J McGuire et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Structure and expression of the Ah receptor repressor gene
T Baba et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Use of cDNA microarrays to analyze dioxin-induced changes in human liver gene expression
FW Frueh et al.
TOXICOLOGY LETTERS (2001)
The transcriptional signature of dioxin in human hepatoma HepG2 cells
A Puga et al.
BIOCHEMICAL PHARMACOLOGY (2000)
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