☆ 4.7 Review

Peptide-based drug discovery: Current status and recent advances

DRUG DISCOVERY TODAY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

Synthetic amino acids-derived peptides target Cryptococcus neoformans by inducing cell membrane disruption

Komal Sharma et al.

Summary: We used synthetic amino acids to design short peptide-based antibiotics. The designed peptides were synthesized using tautomerically restricted, amphiphilic 1-aryl-L-histidines and hydrophobic tryptophan. The peptides L-Trp-L-His(1-biphenyl)-NHBzl (12e, IC50 = 1.91μg/mL; MIC = 3.46μg/mL) and L-His[1-(4-n-butylphenyl)]-L-Trp-L-His[1-(4-n-butylphenyl)]-NHBzl (16d, IC50 = 1.36μg/mL; MIC = 2.46μg/mL) showed high potency against Cryptococcus neoformans. Peptides with moderate antibacterial activities (IC50s = 4.40-8.80μg/mL) were also found. The mechanism of action involved membrane disruption and DNA fragmentation, leading to cell death.

BIOORGANIC CHEMISTRY (2023)

添加到收藏夹

Article Pharmacology & Pharmacy

Potential of cell-penetrating peptides (CPPs) in delivery of antiviral therapeutics and vaccines

Issa Sadeghian et al.

Summary: Viral infections pose a great threat to human health, but there is a lack of effective vaccines and antiviral drugs. Cell-penetrating peptides (CPPs) have the potential for intracellular delivery of various antiviral agents, offering promise for antiviral therapy.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Phage Display-Derived Peptide for the Specific Binding of SARS-CoV-2

Fan Yang et al.

Summary: The COVID-19 pandemic has caused global devastation since the end of 2019. With limited vaccine manufacturing capacity, rapid and accurate diagnostics, along with effective therapeutics, are crucial. In this study, a phage display peptide library was used to identify SARS-CoV-2-specific peptides, with promising results for rapid and accurate detection of the virus.

ACS OMEGA (2022)

添加到收藏夹

Article Chemistry, Analytical

Bioorthogonal Light-Up Fluorescent Probe Enables Wash-Free Real-Time Dynamic Monitoring of Cellular Glucose Uptake

Zhenhao Liang et al.

Summary: This article describes a bioorthogonal light-up fluorescent probe that can rapidly and highly specifically and sensitively detect live-cell glucose uptake. The probe has the advantage of being wash-free, allowing real-time dynamic monitoring of cellular glucose uptake, and successfully differentiating cancer cells from normal cells.

ANALYTICAL CHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Organic

Peptide-Heterocycle Conjugates as Antifungals Against Cryptococcosis

Krishna K. Sharma et al.

Summary: In the past three decades, only one new antifungal drug has been approved by the FDA. Finding new drugs with novel mechanisms of action is an important goal in current antifungal research. This study describes the synthesis and in vitro antimicrobial activities of a new class of peptidomimetics, which showed promising antifungal activity against Cryptococcus neoformans.

ASIAN JOURNAL OF ORGANIC CHEMISTRY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Antifungal evaluation and mechanistic investigations of membrane active short synthetic peptides-based amphiphiles

Komal Sharma et al.

Summary: Researchers have designed and synthesized a new class of peptide sequences with modified amphiphilic properties, demonstrating promising antifungal and antibacterial activities. One particular peptide (13d) showed the most potential as an antifungal agent against C. neoformans, with no cytotoxicity or hemolysis at effective doses.

BIOORGANIC CHEMISTRY (2022)

添加到收藏夹

Review Microbiology

Phage display and other peptide display technologies

Weronika Jaroszewicz et al.

Summary: Phage display technology is a widely applicable method in biotechnology, recognized by the Nobel Prize. This article provides an overview of the technology, including comparisons of different display systems, their advantages and disadvantages, and examples of applications in various fields. It also discusses other peptide display technologies and highlights the ongoing development and improvements in these methods, offering new solutions in the future.

FEMS MICROBIOLOGY REVIEWS (2022)

添加到收藏夹

Article Chemistry, Medicinal

Modified histidine containing amphipathic ultrashort antifungal peptide, His[2-p-(n-butyl)phenyl]-Trp-Arg-OMe exhibits potent anticryptococcal activity

Krishna K. Sharma et al.

Summary: A new structural class of ultrashort peptide-based antifungal, His(2-aryl)-Trp-Arg, was reported in this study. Structural changes on the His-Trp-Arg scaffold showed the impact of charge and lipophilic character on biological activity. Peptide 14f exhibited potent anticryptococcal activity and showed no cytotoxic effects, acting through nuclear fragmentation, membrane permeabilization, and pore formations in microbial cells.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

A Global Review on Short Peptides: Frontiers and Perspectives

Vasso Apostolopoulos et al.

Summary: Peptides, as fragments of proteins, play vital roles in biological processes with unique characteristics and promising potentials in biotherapies. Current research focuses on short peptide-based therapeutic developments, covering disease treatments, biosynthesis, nanotechnology, peptide limitations overcoming, among others.

MOLECULES (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Identification of highly selective covalent inhibitors by phage display

Shiyu Chen et al.

Summary: A phage display method was developed to screen for covalent inhibitors that bind to protein targets by introducing a reactive linker to form cyclic peptides and an electrophilic 'warhead' to react with target nucleophiles. This approach identified cyclic peptides that irreversibly inhibited cysteine protease and serine hydrolase with high specificity and potency. It enables rapid, unbiased screening to identify new classes of highly selective covalent inhibitors for diverse molecular targets.

NATURE BIOTECHNOLOGY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

A DNA-Encoded Chemical Library Based on Peptide Macrocycles

Yuichi Onda et al.

Summary: This study describes the synthesis and characterization of a novel DNA-encoded library of macrocyclic peptide derivatives, which was constructed based on three sets of amino acid building blocks and utilized CuAAC reaction for ring closure. The library, named YO-DEL, with 1,254,838 compounds, was screened against target proteins using affinity capture procedures and photocrosslinking, resulting in specific binders against serum albumins, carbonic anhydrases and NKp46.

CHEMISTRY-A EUROPEAN JOURNAL (2021)

添加到收藏夹

Article Chemistry, Medicinal

Trends in Hit-to-Lead Optimization Following DNA-Encoded Library Screens

Christopher A. Reiher et al.

Summary: DNA-encoded library (DEL) screens are a powerful tool for hit-finding in biological targets, and studies have shown that the molecular property changes post-DEL screening are similar to those in hit-to-lead optimization following high throughput screens. Unique aspects of DEL, such as combinatorial synthetic methods and linker effects at the DNA attachment point, impact the strategies and outcomes of hit-to-lead optimizations.

ACS MEDICINAL CHEMISTRY LETTERS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A minimalistic cyclic ice-binding peptide from phage display

Corey A. Stevens et al.

Summary: Developing molecules that mimic the properties of naturally occurring ice-binding proteins is challenging, but researchers have used phage display to identify a short peptide mimic containing only 14 amino acids. Key residues were identified through mutational analysis, and molecular dynamics simulations revealed a potential mechanism of action for ice binding. The peptide was also utilized for protein purification directly from cell lysate, demonstrating its biotechnological potential.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models

Makoto Saito et al.

Summary: Researchers have developed a class of macrocyclic peptides named iHA, which can bind the influenza viral envelope protein hemagglutinin and inhibit virus infection by blocking adsorption and fusion. Particularly, iHA-100 shows powerful efficacy in inhibiting the growth of highly pathogenic influenza viruses and preventing severe pneumonia at later stages of infection in mouse and non-human primate cynomolgus macaque models, indicating its potential as a next-generation, mid-sized biomolecule.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Enabling Cysteine-Free Native Chemical Ligation at Challenging Junctions with a Ligation Auxiliary Capable of Base Catalysis

Olaf Fuchs et al.

Summary: This study introduces a new auxiliary, MPyE, designed to catalyze ligation reactions in chemical protein synthesis. The MPyE auxiliary proves to be effective in providing useful rates even for junctions containing proline or a beta-branched amino acid.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Role of Peptides in Diagnostics

Shashank Pandey et al.

Summary: This article discusses the application of synthetic peptides in diagnostics, including imaging and non-imaging diagnostics; introduces the peptide-based ELISA technology and the use of peptides in imaging techniques; emphasizes the advantages and disadvantages of peptides; also explores the application of peptides in deadly diseases such as COVID-19 and cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Allenone-Mediated Racemization/Epimerization-Free Peptide Bond Formation and Its Application in Peptide Synthesis

Zhengning Wang et al.

Summary: Allenone has been identified as a highly effective peptide coupling reagent for the first time, showcasing its robustness in forming peptide bonds. It is not only effective for synthesizing simple amides and dipeptides, but also suitable for peptide fragment condensation and solid-phase peptide synthesis (SPPS). This method represents a disruptive innovation in peptide synthesis by combining the advantages of conventional active esters and coupling reagents while overcoming their disadvantages.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy

Masoud Delfi et al.

Summary: Self-assembled peptides and proteins have great potential as targeted drug delivery systems, especially in anti-cancer therapy. They can form diverse nanostructures in response to environmental conditions and offer good biocompatibility and high loading capacity for drugs, making them ideal for specific targeting of tumor cells.

NANO TODAY (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Bioorthogonal information storage in L-DNA with a high-fidelity mirror-image Pfu DNA polymerase

Chuyao Fan et al.

Summary: Researchers have developed a mirror-image DNA that can store genetic information and is resistant to biodegradation, as well as synthesized a high-fidelity mirror-image DNA polymerase. They used this polymerase to encode an article about a mirror-image world in mirror-image DNA, and achieved chiral steganography. The study also showed that mirror-image DNA can be stored in water for longer periods of time, potentially advancing the development of mirror-image biology systems.

NATURE BIOTECHNOLOGY (2021)

添加到收藏夹

Review Virology

Discovery of Antivirals Using Phage Display

Esen Sokullu et al.

Summary: The outbreak of the latest coronavirus disease, COVID-19, has highlighted the serious threat posed by viral infections to global public health throughout history. The development of antiviral agents, particularly peptide/protein-based drug molecules like antibodies, has become crucial in combating existing and emerging viral infections. Phage display has emerged as a widely used screening method for peptide/antibody drug discovery, with a growing interest in utilizing this technology to enhance antiviral potency.

VIRUSES-BASEL (2021)

添加到收藏夹

Article Chemistry, Physical

En Route to a Heterogeneous Catalytic Direct Peptide Bond Formation by Zr-Based Metal-Organic Framework Catalysts

Francisco de Azambuja et al.

Summary: The study explores the catalytic activity of Zr-6-based metal-organic frameworks in peptide bond formation, showing good stability and recyclability in dipeptide cyclization reactions without the need for additional activators. The results indicate that the catalyst can be applied to substrates with bulky and Lewis basic groups, and the reaction is driven by a mechanism involving Lewis acid activation of carboxylate groups towards amine addition.

ACS CATALYSIS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein Using mRNA Display

Alexander Norman et al.

Summary: The COVID-19 pandemic caused severe morbidity, mortality, and disruption globally. Research has identified cyclic peptide ligands with high affinity to the SARS-CoV-2 spike protein receptor binding domain, which may have potential future use as diagnostic reagents.

ACS CENTRAL SCIENCE (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Depsipeptide synthesis using a late-stage Ag(i)-promoted macrolactonisation of peptide thioamides

Sadegh Shabani et al.

Summary: This study presents a novel macrolactonisation strategy using Ag(i)-promoted conversion of peptide thioamides to isoimide intermediates, which undergo site-selective intramolecular acyl transfer to generate the macrolactone.

CHEMICAL COMMUNICATIONS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Metal-free approach for hindered amide-bond formation with hypervalent iodine(III) reagents: application to hindered peptide synthesis

Hyo-Jun Lee et al.

Summary: A new bio-inspired approach for amide and peptide synthesis using a-amino esters with a potential activating group (PAG) at the ester residue is reported. The ester functionality is activated under mild metal-free conditions by exploiting the dearomatization of phenols with hypervalent iodine(III) reagents. Highly reactive acyl fluoride intermediates are successfully generated using a pyridine hydrogen fluoride complex, facilitating the smooth formation of sterically hindered amides and peptides from bulky amines and a-amino esters.

GREEN CHEMISTRY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

The effect of lipidation and glycosylation on short cationic antimicrobial peptides

Elizabeth Grimsey et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2020)

添加到收藏夹

Article Chemistry, Organic

Site-Specific Incorporation of Multiple Thioamide Substitutions into a Peptide Backbone via Solid Phase Peptide Synthesis

Jinhua Yang et al.

JOURNAL OF ORGANIC CHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Physical

Catalytic Dehydrative Peptide Synthesis with gem-Diboronic Acids

Kenichi Michigami et al.

ACS CATALYSIS (2020)

添加到收藏夹

Review Nanoscience & Nanotechnology

Materials for oral delivery of proteins and peptides

Tyler D. Brown et al.

NATURE REVIEWS MATERIALS (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

The Staudinger Ligation

Christin Bednarek et al.

CHEMICAL REVIEWS (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Stapled Helical Peptides Bearing Different Anchoring Residues

Xiang Li et al.

CHEMICAL REVIEWS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Enhancing native chemical ligation for challenging chemical protein syntheses

Riley J. Giesler et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2020)

添加到收藏夹

Article Microbiology

D- and Unnatural Amino Acid Substituted Antimicrobial Peptides With Improved Proteolytic Resistance and Their Proteolytic Degradation Characteristics

Jianguang Lu et al.

FRONTIERS IN MICROBIOLOGY (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Peptide macrocyclization by transition metal catalysis

Daniel G. Rivera et al.

CHEMICAL SOCIETY REVIEWS (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Peptidomimetic toolbox for drug discovery

Elena Lenci et al.

CHEMICAL SOCIETY REVIEWS (2020)

添加到收藏夹

Article Chemistry, Organic

Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production

Albert Isidro-Llobet et al.

JOURNAL OF ORGANIC CHEMISTRY (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Understanding Cell Penetration of Cyclic Peptides

Patrick G. Dougherty et al.

CHEMICAL REVIEWS (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations

Vangelis Agouridas et al.

CHEMICAL REVIEWS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Substrate-Directed Lewis-Acid Catalysis for Peptide Synthesis

Wataru Muramatsu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

添加到收藏夹

Article Biochemical Research Methods

Diselenide-selenoester ligation for chemical protein synthesis

Sameer S. Kulkarni et al.

NATURE PROTOCOLS (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

New tools for recombinant protein production in Escherichia coli: A 5-year update

German L. Rosano et al.

PROTEIN SCIENCE (2019)

添加到收藏夹

Article Biochemical Research Methods

DNA-Encoded Combinatorial Library of Macrocyclic Peptoids

Min Hyeon Shin et al.

BIOCONJUGATE CHEMISTRY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Late-stage peptide C-H alkylation for bioorthogonal C-H activation featuring solid phase peptide synthesis

Alexandra Schischko et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Engineering, Biomedical

A stabilized retro-inverso peptide ligand of transferrin receptor for enhanced liposome-based hepatocellular carcinoma-targeted drug delivery

Jiajing Tang et al.

ACTA BIOMATERIALIA (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Late-Stage Peptide Diversification through Cobalt-Catalyzed C-H Activation: Sequential Multicatalysis for Stapled Peptides

Melanie M. Lorion et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Non-invasive delivery strategies for biologics

Aaron C. Anselmo et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Green Transformation of Solid-Phase Peptide Synthesis

Yahya E. Jad et al.

ACS SUSTAINABLE CHEMISTRY & ENGINEERING (2019)

添加到收藏夹

Review Chemistry, Organic

Chemical composition of DNA-encoded libraries, past present and future

Paige Dickson et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Medicinal

The Current State of Peptide Drug Discovery: Back to the Future?

Antoine Henninot et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Lipidated Peptide Dendrimers Killing Multidrug-Resistant Bacteria

Thissa N. Siriwardena et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Serine/Threonine Ligation: Origin, Mechanistic Aspects, and Applications

Han Liu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Tyr1-ψ[(Z)CF=CF]-Gly2 Fluorinated Peptidomimetic Improves Distribution and Metabolism Properties of Leu-Enkephalin

Ryan A. Altman et al.

ACS CHEMICAL NEUROSCIENCE (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Late-Stage Peptide Diversification by Position-Selective C-H Activation

Wei Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Therapeutic peptides: Historical perspectives, current development trends, and future directions

Jolene L. Lau et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Peptide modification and cyclization via transition-metal catalysis

Lara R. Malins

CURRENT OPINION IN CHEMICAL BIOLOGY (2018)

添加到收藏夹

Article Chemistry, Organic

Traceless Staudinger Ligation for Biotinylation of Acetylated Thiol-azido Heterobi-functional Linker and its Attachment to Gold Surface

Subhadip Senapati et al.

CURRENT ORGANIC CHEMISTRY (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Phage Display of Dynamic Covalent Binding Motifs Enables Facile Development of Targeted Antibiotics

Kelly A. McCarthy et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

添加到收藏夹

Article Chemistry, Physical

Catalytic Peptide Synthesis: Amidation of N-Hydroxyimino Esters

Wataru Muramatsu et al.

ACS CATALYSIS (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Orally Active Peptides: Is There a Magic Bullet?

Andreas F. B. Raeder et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

添加到收藏夹

Article Chemistry, Medicinal

N-Terminus Alkylation of Vancomycin: Ligand Binding Affinity, Antimicrobial Activity, and Site-Specific Nature of Quaternary Trimethylammonium Salt Modification

Zhi-Chen Wu et al.

ACS INFECTIOUS DISEASES (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Design and Application of a DNA-Encoded Macrocyclic Peptide Library

Zhengrong Zhu et al.

ACS CHEMICAL BIOLOGY (2018)

添加到收藏夹

Article Chemistry, Organic

Regioselective Access to 1,2-Diarylhistidines through the Copper-Catalyzed N1-Arylation of 2-Arylhistidines

Krishna K. Sharma et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2017)

添加到收藏夹

Article Chemistry, Medicinal

Discovery of a Membrane-Active, Ring-Modified Histidine Containing Ultrashort Amphiphilic Peptide That Exhibits Potent Inhibition of Cryptococcus neoformans

Krishna K. Sharma et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

添加到收藏夹

Article Chemistry, Organic

General, Mild, and Metal-Free Synthesis of Phenyl Selenoesters from Anhydrides and Their Use in Peptide Synthesis

Andrea Temperini et al.

JOURNAL OF ORGANIC CHEMISTRY (2017)

添加到收藏夹

Article Chemistry, Organic

Chemical Synthesis of GPI Glycan Peptide Conjugates by Traceless Staudinger Ligation

Sanyong Zhu et al.

ORGANIC LETTERS (2017)

添加到收藏夹

Article Cell Biology

Mirror-image polymerase chain reaction

Wenjun Jiang et al.

CELL DISCOVERY (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Chemical Protein Synthesis with the α-Ketoacid-Hydroxylamine Ligation

Jeffrey W. Bode

ACCOUNTS OF CHEMICAL RESEARCH (2017)

添加到收藏夹

Review Chemistry, Multidisciplinary

Azapeptide Synthesis Methods for Expanding Side-Chain Diversity for Biomedical Applications

Ramesh Chingle et al.

ACCOUNTS OF CHEMICAL RESEARCH (2017)

添加到收藏夹

Review Pharmacology & Pharmacy

DNA-encoded chemical libraries: foundations and applications in lead discovery

Gunther Zimmermann et al.

DRUG DISCOVERY TODAY (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ynamides as Racemization-Free Coupling Reagents for Amide and Peptide Synthesis

Long Hu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

A synthetic molecular system capable of mirror-image genetic replication and transcription

Zimou Wang et al.

NATURE CHEMISTRY (2016)

添加到收藏夹

Article Chemistry, Organic

Regioselective copper-catalyzed N(1)-(hetero)-arylation of protected histidine

Krishna K. Sharma et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2016)

添加到收藏夹

Review Chemistry, Multidisciplinary

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes

Marta Pelay-Gimeno et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Borinic acid catalysed peptide synthesis

Tharwat Mohy El Dine et al.

CHEMICAL COMMUNICATIONS (2015)

添加到收藏夹

Review Pharmacology & Pharmacy

Peptide therapeutics: current status and future directions

Keld Fosgerau et al.

DRUG DISCOVERY TODAY (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Site-Specific PEGylation of Therapeutic Proteins

Jonathan K. Dozier et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

添加到收藏夹

Article Chemistry, Organic

Catalytic Chemical Amide Synthesis at Room Temperature: One More Step Toward Peptide Synthesis

Tharwat Mohy El Dine et al.

JOURNAL OF ORGANIC CHEMISTRY (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Aldehyde Capture Ligation for Synthesis of Native Peptide Bonds

Monika Raj et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

添加到收藏夹

Article Chemistry, Organic

Iodine-Mediated Oxidative Coupling of Hydroxamic Acids with Amines towards a New Peptide-Bond Formation

Muniyappa Krishnamurthy et al.

SYNLETT (2015)

添加到收藏夹

Review Microbiology

Illumination of growth, division and secretion by metabolic labeling of the bacterial cell surface

M. Sloan Siegrist et al.

FEMS MICROBIOLOGY REVIEWS (2015)

添加到收藏夹

Review Chemistry, Multidisciplinary

Constraining Cyclic Peptides To Mimic Protein Structure Motifs

Timothy A. Hill et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

添加到收藏夹

Review Chemistry, Multidisciplinary

C-H Functionalization in the Synthesis of Amino Acids and Peptides

Anais F. M. Noisier et al.

CHEMICAL REVIEWS (2014)

添加到收藏夹

Review Chemistry, Multidisciplinary

Emerging micro-and nanotechnology based synthetic approaches for insulin delivery

Ran Mo et al.

CHEMICAL SOCIETY REVIEWS (2014)

添加到收藏夹

Review Chemistry, Multidisciplinary

Peptidomimetics via modifications of amino acids and peptide bonds

Ilker Avan et al.

CHEMICAL SOCIETY REVIEWS (2014)

添加到收藏夹

Article Pharmacology & Pharmacy

Dulaglutide: First Global Approval

Mark Sanford

DRUGS (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Solvent-free peptide synthesis assisted by microwave irradiation: environmentally benign synthesis of bioactive peptides

Amit Mahindra et al.

RSC ADVANCES (2014)

添加到收藏夹

Article Chemistry, Organic

Palladium-Catalyzed Regioselective C-5 Arylation of Protected L-Histidine: Microwave-Assisted C-H Activation Adjacent to Donor Arm

Amit Mahindra et al.

JOURNAL OF ORGANIC CHEMISTRY (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Microwave-assisted solution phase peptide synthesis in neat water

Amit Mahindra et al.

RSC ADVANCES (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Peptides As Therapeutics with Enhanced Bioactivity

D. Goodwin et al.

CURRENT MEDICINAL CHEMISTRY (2012)

添加到收藏夹

Article Chemistry, Organic

Rapid microwave-assisted solution-phase peptide synthesis

Amit Mahindra et al.

TETRAHEDRON LETTERS (2012)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synthesis of Peptides and Pyrazines from ss-Amino Alcohols through Extrusion of H2 Catalyzed by Ruthenium Pincer Complexes: Ligand-Controlled Selectivity

Boopathy Gnanaprakasam et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

添加到收藏夹

Article Chemistry, Multidisciplinary

20 years of DNA-encoded chemical libraries

Luca Mannocci et al.

CHEMICAL COMMUNICATIONS (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Natural Product-Like Macrocyclic N-Methyl-Peptide Inhibitors against a Ubiquitin Ligase Uncovered from a Ribosome-Expressed De Novo Library

Yusuke Yamagishi et al.

CHEMISTRY & BIOLOGY (2011)

添加到收藏夹

Review Pharmacology & Pharmacy

Synthetic therapeutic peptides: science and market

Patrick Vlieghe et al.

DRUG DISCOVERY TODAY (2010)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives

Nicholas A. McGrath et al.

JOURNAL OF CHEMICAL EDUCATION (2010)

添加到收藏夹

Article Pharmacology & Pharmacy

Degarelix

James E. Frampton et al.

DRUGS (2009)

添加到收藏夹

Article Chemistry, Medicinal

Discovery of Trp-His and His-Arg Analogues as New Structural Classes of Short Antimicrobial Peptides

Rohit K. Sharma et al.

JOURNAL OF MEDICINAL CHEMISTRY (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Design, synthesis and selection of DNA-encoded small-molecule libraries

Matthew A. Clark et al.

NATURE CHEMICAL BIOLOGY (2009)

添加到收藏夹

Article Chemistry, Multidisciplinary

Convergent chemical synthesis and crystal structure of a 203 amino acid covalent dimer HIV-1 protease enzyme molecule

Vladimir Yu. Torbeev et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)

添加到收藏夹

Article Chemistry, Multidisciplinary

A phage display system with unnatural amino acids

T Feng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)

添加到收藏夹

Article Multidisciplinary Sciences

Design and chemical synthesis of a homogeneous polymer-modified erythropoiesis protein

GG Kochendoerfer et al.

SCIENCE (2003)

添加到收藏夹

Article Chemistry, Multidisciplinary

Extending synthetic access to proteins with a removable acyl transfer auxiliary

J Offer et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.