Peptide-based drug discovery: Current status and recent advances

The progressive development of peptides from reaction vessels to life-saving drugs via rigorous preclinical and clinical assessments is fascinating. Peptide therapeutics have gained momentum with the evolution of tech-niques in peptide chemistry, such as microwave irradi-ation in solid-and solution-phase synthesis, ligation chemistry, recombinant synthesis, and amalgamation with synthetic tools, including metal catalysis. Diverse emerging technologies, such as DNA-encoded libraries (DELs) and display techniques, are changing the status quo in the discovery of peptide therapeutics. In this review, we analyzed US Food and Drug Administration (FDA)-approved peptide drugs and those in clinical trials, highlighting recent advances in peptide-based drug discovery.

Automated summary

The development of peptide therapeutics from reaction vessels to life-saving drugs has been fascinating. Advances in peptide chemistry techniques have contributed to the progress, including microwave irradiation, ligation chemistry, recombinant synthesis, and integration with metal catalysis. Emerging technologies, such as DNA-encoded libraries and display techniques, are changing the landscape of peptide drug discovery. This review analyzes FDA-approved peptide drugs and those in clinical trials, highlighting recent advances in peptide-based drug discovery.