期刊
JOURNAL OF NUTRITION
卷 146, 期 11, 页码 2252-2259出版社
AMER SOC NUTRITION-ASN
DOI: 10.3945/jn.116.239418
关键词
bagel; functional food; glucose; high-amylose maize; HAM-RS2; insulin; postprandial; resistant starch; type 2 diabetes
资金
- Ontario Ministry of Agriculture, Food, and Rural Affairs [200395]
- Canada Bread Limited
Background: Type 2 diabetes (T2D) incidence continues to rise. Although increasing dietary fiber intake is an established strategy for improved glycemic control, most adults consume insufficient amounts. Fiber-enhanced functional foods can increase fiber intake, and there is particular interest in resistant starch (RS) as a high-fiber ingredient. Studies show that high-amylose maize resistant starch, type 2 (HAM-RS2) improves acute and chronic glycemic responses, but more studies are needed in individuals at high risk of T2D with RS delivered in commonly consumed foods. Objective: The objective of this study was to examine the chronic effects of consuming bagels high in HAM-RS2 on fasting and postprandial glycemic markers in adults at increased risk of T2D. Methods: With the use of a randomized, double-blind crossover design, 24 men and women with a mean +/- SE age of 55.3 +/- 1.59 y and body mass index (in kg/m(2)) of 30.2 +/- 0.57 consumed 1 bagel containing 25 g HAM-RS2/d or 1 control wheat bagel/d for 56 d each, separated by a 4-wk washout. Fasting and postprandial oral-glucose-tolerance test (OGTT) glucose and insulin were measured on study days 1 and 57 of each bagel treatment. Results: The RS bagel treatment resulted in significantly lower fasting (22.1 %, P= 0.04), 2-h (23.3%, P < 0.008), and 3-h (18.9%, P= 0.05) insulin incremental areas under the curve and fasting insulin resistance (homeostasis model assessment of insulin resistance; 23.1 %, P = 0.04) than did the control bagel treatment. Fasting and postprandial OGTT glucose concentrations did not differ between the RS and control bagel treatments on study days 1 or 57. Conclusions: These data suggest that consumption of a high HAM-RS2 bagel improves glycemic efficiency by reducing the amount of insulin required to manage postprandial glucose while improving fasting insulin sensitivity in adults at increased risk of T2D. This research provides support for a feasible dietary strategy for T2D risk reduction. This trial was registered at clinicaltrials.gov as NCT02129946.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据