Crosstalk Between β-CATENIN-Mediated Cell Adhesion and the WNT Signaling Pathway

Cell adhesion and stable signaling regulation are fundamental ways of maintaining homeostasis. Among them, the Wnt/beta-CATENIN signaling plays a key role in embryonic development and maintenance of body dynamic homeostasis. At the same time, the key signaling molecule beta-CATENIN in the Wnt signaling can also function as a cytoskeletal linker protein to regulate tissue barriers, cell migration, and morphogenesis. Dysregulation of the balance between Wnt signaling and adherens junctions can lead to disease. How beta-CATENIN maintains the independence of these two functions, or mediates the interaction and balance of these two functions, has been explored and debated for a long time. In this study, we will focus on five aspects of beta-CATENIN chaperone molecules, phosphorylation of beta-CATENIN and related proteins, epithelial mesenchymal transition, beta-CATENIN homolog protein gamma-CATENIN and disease, thus deepening the understanding of the Wnt/beta-CATENIN signaling and the homeostasis between cell adhesion and further addressing related disease problems.

Automated summary

This study investigates the mechanism of maintaining balance between cell adhesion and signal regulation by focusing on the role of β-CATENIN. The study deepens the understanding of the Wnt/β-CATENIN signaling pathway through exploring β-CATENIN chaperone molecules, phosphorylation, epithelial mesenchymal transition, and their connection to disease.