期刊
JOURNAL OF NUTRITION
卷 146, 期 2, 页码 422S-426S出版社
OXFORD UNIV PRESS
DOI: 10.3945/jn.114.202432
关键词
adiponectin; cardiovascular disease; diabetes mellitus; aged garlic extract; visceral fat; nutritional interventions; metabolic syndrome
资金
- University of California, Los Angeles School of Medicine
- University of Florida
- American Botanical Council
- American Herbal Products Association
- ASN
- Japanese Society for Food Factors
- Japan Society for Bioscience, Biotechnology, and Agrochemistry
- Japan Society of Nutrition and Food Science
- Natural Products Association
- Wakunaga of America Co., Ltd.
Adiponectin is an adipocyte-derived hormone abundantly present in plasma that exerts its effects through the activation of 3 receptors. Its concentrations are negatively regulated by the accumulation of visceral fat, and clinical studies implicate hypoadiponectinemia in the pathogenesis of diabetes mellitus type 2, coronary artery disease, hypertension, and left ventricular hypertrophy, In contrast, high concentrations of adiponectin are associated with a decreased risk of coronary artery disease, with an improvement in the differentiation of preadipocytes into adipocytes, and with increased endothelial nitric oxide production. Therefore, adiponectin appears to be an important molecule involved in limiting the pathogenesis of obesity -linked disorders, and it may have potential benefits in the treatment and prevention of cardiovascular disease. Caloric restriction, moderate alcohol consumption, and consuming a Mediterranean diet increase adiponectin concentrations, and current evidence suggests a positive, dose-dependent relation between omega-3 (n-3) fatty acid intake and circulating concentrations of adiponectin. Recently, it was reported that the administration of aged garlic extract and a single food intervention with pistachios can increase adiponectin concentrations in individuals with metabolic syndrome. Moreover, the Mediterranean diet is associated with higher adiponectin concentrations. Additional studies are needed to evaluate the potential benefits of increasing adiponectin by nutritional interventions in the treatment and prevention of cardiometabolic diseases.
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