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Editorial Material
Medicine, General & Internal
Adam S. Lauring et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Pathology
Priya Velu et al.
Summary: This study presents the clinical validation and implementation of a laboratory-developed real-time RT-PCR test for SARS-CoV-2 in the NewYork-Presbyterian Hospital system. The test exhibited excellent accuracy and comparable diagnostic performance to reference tests, with an increasing positivity rate observed from the start to the end of testing. It demonstrates the assay's accurate and sensitive identification of SARS-CoV-2 in various specimen types in the clinical setting.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2021)
Article
Microbiology
Zhuoming Liu et al.
Summary: The study found that antibodies targeting the SARS-CoV-2 spike protein have escape mutations, different monoclonal antibodies have unique resistance profiles, some mutants are resistant to multiple antibodies while some variants can escape neutralization by convalescent sera. Comparing antibody-mediated mutations with circulating SARS-CoV-2 sequences revealed substitutions that may weaken neutralizing immune responses in some individuals, warranting further investigation.
CELL HOST & MICROBE
(2021)
Article
Multidisciplinary Sciences
Houriiyah Tegally et al.
Summary: The article describes a newly emerged lineage of SARS-CoV-2, 501Y.V2, characterized by eight mutations in the spike protein, which may result in increased transmissibility or immune escape. This lineage originated in South Africa and quickly became dominant in Eastern Cape, Western Cape, and KwaZuluNatal provinces within weeks.
Article
Multidisciplinary Sciences
Nicholas G. Davies et al.
Summary: A new variant of SARS-CoV-2 has emerged in England, with a higher reproduction number and potential for large resurgences of COVID-19 cases. Without stringent control measures, it is projected that COVID-19 hospitalizations and deaths in England for the first 6 months of 2021 will exceed those in 2020. The variant has spread globally and exhibited similar transmission increases in Denmark, Switzerland, and the United States.
Article
Multidisciplinary Sciences
Erik Volz et al.
Summary: Genetic and testing data from England indicate that the SARS-CoV-2 variant B.1.1.7 has a transmission advantage over other lineages, showing a rapid expansion during autumn 2020. Analysis of S gene target failures (SGTF) in community-based diagnostic PCR testing suggests that B.1.1.7 is more transmissible than non-variant of concern lineages and has a significant transmission advantage, with a reproduction number 50% to 100% higher. Additionally, cases of B.1.1.7 appear to include a larger share of under 20-year-olds compared to non-variant cases.
Article
Multidisciplinary Sciences
Nuno R. Faria et al.
Summary: A new variant of concern, P.1, with 17 mutations including three spike protein mutations associated with increased binding to human ACE2 receptors, emerged in Manaus, Brazil between November 2020 and January 2021. Molecular analysis suggests P.1 may be 1.7- to 2.4-fold more transmissible and that previous infection may provide 54 to 79% protection against P.1 infection compared to other lineages. Enhanced global genomic surveillance of such variants is crucial for pandemic response.
Article
Microbiology
Hannah Wang et al.
Summary: This study developed a new nucleic acid amplification test to detect SARS-CoV-2 variants with high sensitivity and specificity. Screening a large cohort of infected individuals in the San Francisco Bay Area revealed a rapid increase in the prevalence of the L452R variant over time.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Microbiology
Huanyu Wang et al.
Summary: A PCR-based detection method has been developed by the research team to identify different variants of SARS-CoV-2, with same-day reporting and demonstrated 100% concordance with whole-genome sequencing results. This method offers a rapid screening approach for early detection of newly emerging variants.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Virology
Andreas Lind et al.
Summary: The study confirmed the effectiveness of Variant PCR based on the protocol by Vogels et al. for rapid screening of B.1.1.7, B.1.351 and P.1, applicable for most diagnostic laboratories within a pandemic setting. WGS is still required to confirm the identity of certain variants and for continuous surveillance of emerging VoC.
JOURNAL OF CLINICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Medini K. Annavajhala et al.
Summary: The emergence of the B.1.526 lineage of SARS-CoV-2, with mutations such as E484K, has led to its rapid dominance in New York City. This variant is resistant to therapeutic monoclonal antibodies and less susceptible to neutralization by antibodies from recovered or vaccinated individuals, contributing to its fast spread.
Review
Genetics & Heredity
Kaiming Tao et al.
Summary: The emergence of multiple SARS-CoV-2 variants has significant impacts on the epidemiological and clinical aspects of the COVID-19 pandemic, including increased virus transmission rates, heightened risk of reinfection, and reduced effectiveness of neutralizing antibodies and vaccines. These variants have introduced new challenges to COVID-19 research, necessitating additional avenues of laboratory, epidemiological, and clinical studies.
NATURE REVIEWS GENETICS
(2021)
Article
Multidisciplinary Sciences
Anthony P. West et al.
Summary: Wide-scale SARS-CoV-2 genome sequencing is crucial for tracking viral evolution. The software tool Variant Database was developed to quickly examine spike mutations, and the emergence and spread of the B.1.526 lineage in New York has extended the second wave of COVID-19 cases.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
Nathan Zelyas et al.
Summary: The study demonstrates the successful implementation of new tests for the rapid detection of SARS-CoV-2 variants of concern, allowing for swift identification and monitoring of the rise of B.1.1.7 cases in Alberta, Canada.
MICROBIOLOGY SPECTRUM
(2021)
Letter
Immunology
Peter T. Skidmore et al.
Summary: Genomic surveillance is crucial in early detection of new SARS-CoV-2 variants, with the identification of an emergent variant B.1.243.1 carrying the E484K mutation highlighting the importance of real-time surveillance in informing public health responses.
EMERGING INFECTIOUS DISEASES
(2021)
News Item
Multidisciplinary Sciences
Ewen Callaway
