Frailty is associated with the progression of prediabetes to diabetes and elevated risks of cardiovascular disease and all-cause mortality in individuals with prediabetes and diabetes: Evidence from two prospective cohorts

Article Geriatrics & Gerontology

Risk of progression to diabetes and mortality in older people with prediabetes: The English longitudinal study on ageing

Nicola Veronese et al.

Summary: This study examined the prevalence of prediabetes in elderly populations and found that the progression of prediabetes to diabetes is uncommon, while regression to normoglycemia or progression to death is more frequent.

AGE AND AGEING (2022)

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Review Environmental Sciences

Management of Type 2 Diabetes Mellitus in Elderly Patients with Frailty and/or Sarcopenia

Jaime Sanz-Canovas et al.

Summary: The increasing life expectancy worldwide has led to a higher prevalence of type 2 diabetes mellitus (T2DM) in the elderly, who also frequently suffer from sarcopenia and frailty. These three conditions share common mechanisms, such as insulin resistance, chronic inflammation, and mitochondrial dysfunction. The coexistence of these conditions worsens the prognosis of elderly patients. This paper reviews the main measures for preventing and managing sarcopenia and/or frailty in elderly patients with T2DM.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

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Article Medicine, General & Internal

Effect of Sarcopenia on Mortality in Type 2 Diabetes: A Long-Term Follow-Up Propensity Score-Matched Diabetes Cohort Study

Jui-An Lin et al.

Summary: This study aims to investigate the impact of sarcopenia on the survival of patients with type 2 diabetes. According to the results, patients with diabetes and sarcopenia have a higher mortality rate compared to those without sarcopenia.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Medicine, General & Internal

Association between sarcopenia and cardiovascular disease among middle-aged and older adults: Findings from the China health and retirement longitudinal study

Ke Gao et al.

Summary: This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS) to investigate the association between sarcopenia and cardiovascular disease (CVD) among middle-aged and older adults in China. The findings suggest that sarcopenia, as defined by the AWGS 2019 criteria, is associated with a higher risk of CVD in this population.

ECLINICALMEDICINE (2022)

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Article Endocrinology & Metabolism

12. Older Adults: Standards of Medical Care in Diabetes-2021

Summary: The American Diabetes Association's Standards of Medical Care in Diabetes provides clinical practice recommendations, components of care, treatment goals, and tools for evaluating quality of care. The ADA Professional Practice Committee is responsible for regularly updating the standards, and readers can provide feedback at a designated website.

DIABETES CARE (2021)

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Article Endocrinology & Metabolism

Prediabetes, Diabetes, and the Risk of All-Cause and Cause-Specific Mortality in a Japanese Working Population: Japan Epidemiology Collaboration on Occupational Health Study

Zobida Islam et al.

Summary: Prediabetes defined according to the American Diabetes Association criteria is associated with increased risk of all-cause and cancer deaths, but not cardiovascular disease deaths. In a cohort of Japanese workers, prediabetes defined by FPG and HbA(1c) according to ADA or WHO/IEC criteria is significantly linked to higher mortality risk.

DIABETES CARE (2021)

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Article Medicine, General & Internal

Prevalence and Treatment of Diabetes in China, 2013-2018

Limin Wang et al.

Summary: Based on national data collected in China from 2013 to 2018, the prevalence of diabetes increased, while awareness, treatment, and control of diabetes did not significantly improve. Risk factors such as low physical activity and high intake of red meat, overweight, and obesity also increased during this period.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Review Oncology

Sarcopenia, frailty and type 2 diabetes mellitus

Hiroki Nishikawa et al.

Summary: Skeletal muscle plays a crucial role in energy metabolism and glucose uptake. Conditions like type 2 diabetes, frailty, and aging can impact muscle health. Exercise and proper nutrition interventions are key in maintaining muscle health and preventing various diseases.

MOLECULAR MEDICINE REPORTS (2021)

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Article Medicine, General & Internal

Risk of Progression to Diabetes Among Older Adults With Prediabetes

Mary R. Rooney et al.

Summary: This study analyzed prediabetes and diabetes risks among 3412 older adults in a community-based setting. It was found that in older age, high prevalence of prediabetes was observed, with more cases regressing to normal blood glucose levels or resulting in death rather than progressing to diabetes.

JAMA INTERNAL MEDICINE (2021)

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Article Endocrinology & Metabolism

Sarcopenia Is Associated With a Risk of Mortality in People With Type 2 Diabetes Mellitus

Fuyuko Takahashi et al.

Summary: This study investigated the impact of sarcopenia on incident all-cause mortality in older individuals with type 2 diabetes. The results showed that sarcopenia was associated with a significantly increased risk of all-cause mortality in this population.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Medicine, General & Internal

Trends in Prevalence of Diabetes and Control of Risk Factors in Diabetes Among US Adults, 1999-2018

Li Wang et al.

Summary: The study based on NHANES data from US adults reveals a significant increase in the prevalence of diabetes between 1999-2000 and 2017-2018. Only around 21% of adults with diagnosed diabetes achieved all three risk factor control goals in 2015-2018.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Review Endocrinology & Metabolism

Type 2 diabetes mellitus in older adults: clinical considerations and management

Srikanth Bellary et al.

Summary: The prevalence of type 2 diabetes mellitus (T2DM) is increasing among the aging population, presenting challenges in management due to patient heterogeneity, comorbidities, susceptibility to hypoglycemia, increased dependence on care, and frailty. This review focuses on the pathophysiological mechanisms of T2DM in older individuals, new evidence on frailty and sarcopenia, clinical difficulties related to age-associated comorbidities, and implications for guidelines and therapeutic options, highlighting the impact of T2DM on an aging society.

NATURE REVIEWS ENDOCRINOLOGY (2021)

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Article Endocrinology & Metabolism