期刊
DEVELOPMENT
卷 149, 期 24, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.200938
关键词
Foxd1; Rx3; Retinal patterning; Fovea; Area temporalis; OKR; OMR; Zebrafish
资金
- Ministerio de Economia y Competitividad [BFU2014-55918-P, BFU2016-75412-R, BFU201681887-REDT]
- Wellcome Trust [213928/Z/18/Z, 104682/Z/14/Z, 220273/Z/20/Z]
- Medical Research Council [MR/L003775/1, MR/T020164/1]
- Fight for Sight UK [5153/5154]
- Fundacion Ramon Areces
- St George's University of London
- Wellcome Trust [213928/Z/18/Z, 220273/Z/20/Z] Funding Source: Wellcome Trust
This study demonstrates the importance of appropriate retinal patterning during embryonic development for specific visual functions. The interplay of transcription factor Rx3 with Fibroblast Growth Factor and Hedgehog signals regulates the expression of specific regions, leading to the establishment of specialized visual features.
Appropriate patterning of the retina during embryonic development is assumed to underlie the establishment of spatially localised specialisations that mediate the perception of specific visual features. For example, in zebrafish, an area involved in high acuity vision (HAA) is thought to be present in the ventro-temporal retina. Here, we show that the interplay of the transcription factor Rx3 with Fibroblast Growth Factor and Hedgehog signals initiates and restricts foxd1 expression to the prospective temporal retina, initiating naso-temporal regionalisation of the retina. Abrogation of Foxd1 results in the loss of temporal and expansion of nasal retinal character, and consequent absence of the HAA. These structural defects correlate with severe visual defects, as assessed in optokinetic and optomotor response assays. In contrast, optokinetic responses are unaffected in the opposite condition, in which nasal retinal character is lost at the expense of expanded temporal character. Our study indicates that the establishment of temporal retinal character during early retinal development is required for the specification of the HAA, and suggests a prominent role of the temporal retina in controlling specific visual functions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据