期刊
DALTON TRANSACTIONS
卷 52, 期 11, 页码 3279-3286出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2dt02044k
关键词
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Cu(ii) complexes with ATCUN peptide ligands were investigated for their ROS generation and oxidative DNA degradation abilities. However, the biological activity of most ATCUN complexes such as Cu-GGH (Gly-Gly-His) is low. Tuning the redox chemistry by incorporating N-heteroaromatics reinstates ROS production, leading to efficient DNA cleavage.
Cu(ii) complexes with ATCUN peptide ligands have been investigated for their ROS (reactive oxygen species) generation and oxidative DNA degradation abilities. The biological activity of most ATCUN complexes such as Cu-GGH (Gly-Gly-His) is, however, low. Tuning the redox chemistry by incorporation of N-heteroaromatics reinstates ROS production which leads to efficient DNA cleavage.
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