A bioinspired polydopamine-FeS nanocomposite with high antimicrobial efficiency via NIR-mediated Fenton reaction

Ferrous and sulfur ions are essential elements for the human body, which play an active role in maintaining the body's normal physiology. Meanwhile, mussel-inspired polydopamine (PDA) possesses good hydrophilicity and biocompatibility. In the present work, ferrous sulfide embedded into polydopamine nanoparticles (PDA@FeS NPs) was designed and synthesized via a simple predoping polymerization-coprecipitation strategy and the intelligent PDA matrix successfully prevented the oxidation and agglomeration of FeS nanoparticles. Importantly, there was an obvious synergistic enhancement of the photothermal effect between polydopamine and ferrous sulfide. The PDA@FeS NPs exhibited excellent photothermal antibacterial effects against both E. coli and S. aureus. The near-infrared (NIR) light-mediated release of ferrous ions could reach about 26.5% under weakly acidic conditions, further triggering the Fenton reaction to produce toxic hydroxyl radicals (center dot OH) in the presence of hydrogen peroxide. The antibacterial mechanism could be attributed to cell membrane damage and cellular content leakage with the synergistic effect of PTT and CDT. This study highlighted the germicidal efficacy of PDA@FeS NPs and provided a new strategy for designing and developing next-generation antibacterial platforms.

Automated summary

In this study, PDA@FeS NPs were successfully synthesized using a simple predoping polymerization-coprecipitation strategy, and the intelligent PDA matrix effectively prevented the oxidation and agglomeration of FeS nanoparticles. The PDA@FeS NPs exhibited excellent photothermal antibacterial effects against both E. coli and S. aureus, and the release of ferrous ions under weakly acidic conditions triggered the Fenton reaction to produce toxic hydroxyl radicals, leading to cell membrane damage and cellular content leakage.