4.5 Article

Bone marrow microenvironment- induced regulation of Bcl-2 family members in multiple myeloma (MM): Therapeutic implications

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Medicine, General & Internal

Diagnosis and Management of Multiple Myeloma A Review

Andrew J. Cowan et al.

Summary: Multiple myeloma is a hematologic malignancy characterized by abnormal plasma cells in the bone marrow, often leading to anemia, bone disease, and kidney injury. Diagnosis involves measuring various biomarkers, while treatment options include chemotherapy, autologous hematopoietic stem cell transplantation, and maintenance therapy.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

Review Oncology

CDK9 inhibitors in multiple myeloma: a review of progress and perspectives

Jedrzej Borowczak et al.

Summary: Currently, multiple myeloma is considered an incurable disease, but CDK9 inhibitors have emerged as a potential treatment option to overcome resistance and prolong survival. By downregulating gene expressions and restoring tumor-suppressive functions, CDK9 inhibitors have shown promising efficacy in preclinical trials and synergistic effects with other drugs.

MEDICAL ONCOLOGY (2022)

Article Oncology

Notch2 Increases the Resistance to Venetoclax-Induced Apoptosis in Chronic Lymphocytic Leukemia B Cells by Inducing Mcl-1

Stefania Fiorcari et al.

Summary: Chronic lymphocytic leukemia (CLL) has undergone a clinical revolution due to the discovery of key pathogenic mechanisms, but remains an incurable disease due to intrinsic or acquired resistance of the leukemic clone. High levels of Notch2 and Mcl-1 may contribute to increased resistance to venetoclax in CLL cells, and reducing Mcl-1 expression or silencing Notch2 can restore the response to venetoclax.

FRONTIERS IN ONCOLOGY (2022)

Review Oncology

Where We Stand With Precision Therapeutics in Myeloma: Prosperity, Promises, and Pipedreams

Darren Pan et al.

Summary: Multiple myeloma is an incurable disease with varying treatment responses among patients. Precision medicine using biomarkers to predict drug response can expand treatment options and improve efficacy.

FRONTIERS IN ONCOLOGY (2022)

Review Hematology

Exosomes in multiple myeloma: from bench to bedside

Eline Menu et al.

Summary: This review summarizes the role of exosomes in multiple myeloma (MM), including their involvement in osteolysis, angiogenesis, immune suppression, and drug resistance. Targeting exosome secretion could potentially block these processes. The review also discusses current treatment strategies to counter these processes and explores how exosomes can be harnessed to deliver toxic payloads. Additionally, the review provides an overview of clinical studies investigating exosome cargo as potential MM biomarkers in liquid biopsies.
Review Oncology

Tumor-associated macrophages in multiple myeloma: advances in biology and therapy

Jennifer Sun et al.

Summary: MM is a cancer of plasma cells in the bone marrow, with the tumor microenvironment playing a critical role in disease progression. TAMs in the TME have been found to support tumor survival and chemoresistance, highlighting the importance of exploring macrophage-targeted immunotherapy in MM treatment.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

Article Cell Biology

The BCL-2 inhibitor ABT-199/venetoclax synergizes with proteasome inhibition via transactivation of the MCL-1 antagonist NOXA

Sandra Weller et al.

Summary: The BCL-2 inhibitor ABT-199 enhances its anti-tumor effect by blocking BCL-2 and inhibiting MCL-1 through the activation of NOXA. This finding suggests the potential of combining ABT-199 with other drugs for improved cancer treatment.

CELL DEATH DISCOVERY (2022)

Article Chemistry, Medicinal

Chemical modification of NSC12 leads to a specific FGF-trap with antitumor activity in multiple myeloma

Riccardo Castelli et al.

Summary: Inhibition of FGF/FGFR signaling is a promising strategy for the treatment of malignancies dependent on FGF stimulation. Compound 25b has been identified as an effective agent for blocking the proliferation of MM cells by inhibiting FGF-dependent receptor activation. The absence of the hydroxyl group at C3 in compound 1 prevents binding to estrogen receptors, contributing to its antitumor activity.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Hematology

The combination of C-Myc rearrangement and 1q21 gain is associated with poor prognosis in multiple myeloma

Yuanyuan Jin et al.

Summary: The combination of 1q21 gain and Myc rearrangement is associated with poor prognosis in patients with multiple myeloma. High Mcl-1 protein expression is correlated with Myc rearrangement, and inhibiting Mcl-1 expression can suppress Myc protein activation.

ANNALS OF HEMATOLOGY (2021)

Article Biochemistry & Molecular Biology

Cytokine profiles in patients with newly diagnosed multiple myeloma: Survival is associated with IL-6 and IL-17A levels

Jiayan Gu et al.

Summary: This study revealed that serum cytokine levels were significantly higher in patients with newly diagnosed MM compared to healthy controls, and cytokine deregulation, especially that of IL-6 and IL-17A, may serve as powerful predictors of clinical prognosis for MM patients.

CYTOKINE (2021)

Review Oncology

Targeting MCL-1 in cancer: current status and perspectives

Haolan Wang et al.

Summary: MCL-1, an antiapoptotic protein, is frequently overexpressed in many tumor types and closely associated with tumorigenesis, poor prognosis, and drug resistance. Its central role in regulating the mitochondrial apoptotic pathway makes it an attractive target for cancer therapy. Progress has been made towards MCL-1 inhibitors and some have entered clinical trials.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Article Cell Biology

Phosphatase PP2A enhances MCL-1 protein half-life in multiple myeloma cells

Anne Slomp et al.

Summary: The study revealed that overexpression of MCL-1 in multiple myeloma (MM) cells could be caused by increased stability of the MCL-1 protein, possibly due to the action of the phosphatase PP2A. Understanding these mechanisms may lead to novel strategies for inhibiting MCL-1 in MM cells.

CELL DEATH & DISEASE (2021)

Review Oncology

Targeting CDK9 for Anti-Cancer Therapeutics

Ranadip Mandal et al.

Summary: CDK9, in combination with Cyclin T1, plays a crucial role in RNA Polymerase II mediated transcription. Enhanced CDK9 activity in various cancers is associated with poor prognosis, leading to the development of small-molecule inhibitors targeting CDK9. Research is ongoing to develop more specific inhibitors and explore combination therapies with other regulators to enhance anti-cancer effects.

CANCERS (2021)

Review Oncology

CDK9: A Comprehensive Review of Its Biology, and Its Role as a Potential Target for Anti-Cancer Agents

Abel Tesfaye Anshabo et al.

Summary: Cyclin-dependent kinases play a crucial role in cancer development, particularly in cell division and transcription. Dysregulation of the CDK9 pathway has been observed in various hematological and solid malignancies, making it a valuable anticancer target.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Phase I Study of Venetoclax Plus Daratumumab and Dexamethasone, With or Without Bortezomib, in Patients With Relapsed or Refractory Multiple Myeloma With and Without t(11;14)

Nizar J. Bahlis et al.

Summary: Venetoclax in combination with daratumumab and dexamethasone or bortezomib showed promising efficacy and safety in patients with multiple myeloma. Particularly effective in patients with t(11;14) translocation in RRMM.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Review Pharmacology & Pharmacy

Mcl-1 Inhibition: Managing Malignancy in Multiple Myeloma

Omar Al-Odat et al.

Summary: Mcl-1 protein plays a critical role in the progression of multiple myeloma and inhibiting this protein is considered a therapeutic strategy. Remarkable advancements have been made in the development of selective Mcl-1 inhibitors, which can be used as single agents or in combination therapy.

FRONTIERS IN PHARMACOLOGY (2021)

Article Hematology

Heterogeneous modulation of Bcl-2 family members and drug efflux mediate MCL-1 inhibitor resistance in multiple myeloma

Arnold Bolomsky et al.

Summary: Recent studies have identified MCL-1 as a major regulator of apoptosis in multiple myeloma, and further research is needed to optimize the use of MCL-1 inhibitors in clinical practice. Various BH3 mimetics have shown potential as top combination partners for MCL-1 inhibitors, while established drug classes have mainly demonstrated antagonistic effects.

BLOOD ADVANCES (2021)

Article Hematology

Phase 2 study of venetoclax plus carfilzomib and dexamethasone in patients with relapsed/refractory multiple myeloma

Luciano J. Costa et al.

Summary: The study found that treatment with VenKd showed promising response rates in RRMM patients, with an overall response rate of 80% and 92% in t(11;14) patients. The median progression-free survival was 22.8 months.

BLOOD ADVANCES (2021)

Article Biochemistry & Molecular Biology

BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics

Mariana Villalobos-Ortiz et al.

CELL DEATH AND DIFFERENTIATION (2020)

Article Chemistry, Medicinal

Hot-Spots of Mcl-1 Protein

Camille Denis et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Saga of Mcl-1: regulation from transcription to degradation

Viacheslav V. Senichkin et al.

CELL DEATH AND DIFFERENTIATION (2020)

Review Medicine, General & Internal

Anti-VEGF Drugs in the Treatment of Multiple Myeloma Patients

Roberto Ria et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Cell Biology

CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells

Monika Stetkova et al.

CELL DEATH & DISEASE (2020)

Article Biochemistry & Molecular Biology

Cytokine profile in multiple myeloma

Shivali Jasrotia et al.

CYTOKINE (2020)

Article Oncology

IL6 Promotes a STAT3-PRL3 Feedforward Loop via SHP2 Repression in Multiple Myeloma

Phyllis S. Y. Chong et al.

CANCER RESEARCH (2019)

Review Cell Biology

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

Rumani Singh et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

Sajid Khan et al.

NATURE MEDICINE (2019)

Article Biochemistry & Molecular Biology

CDK9: A key player in cancer and other diseases

Lia Carolina Franco et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation

Calla M. Olson et al.

NATURE CHEMICAL BIOLOGY (2018)

Article Medicine, Research & Experimental

Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression

Yawara Kawano et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Review Biochemistry & Molecular Biology

Anti-apoptotic BCL-2 family members in development

Joseph T. Opferman et al.

CELL DEATH AND DIFFERENTIATION (2018)

Review Biochemistry & Molecular Biology

BCL-2 family proteins: changing partners in the dance towards death

Justin Kale et al.

CELL DEATH AND DIFFERENTIATION (2018)

Review Oncology

Evolutionary biology of high-risk multiple myeloma

Charlotte Pawlyn et al.

NATURE REVIEWS CANCER (2017)

Article Multidisciplinary Sciences

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

Andras Kotschy et al.

NATURE (2016)

Article Health Care Sciences & Services

A review of lenalidomide in combination with dexamethasone for the treatment of multiple myeloma

Teru Hideshima

Therapeutics and Clinical Risk Management (2016)

Review Immunology

Targeting B-cell maturation antigen in multiple myeloma

Yu-Tzu Tai et al.

IMMUNOTHERAPY (2015)

Article Oncology

Interleukin-10 Induces Both Plasma Cell Proliferation and Angiogenesis in Multiple Myeloma

Michael G. Alexandrakis et al.

PATHOLOGY & ONCOLOGY RESEARCH (2015)

Review Pharmacology & Pharmacy

Small molecule Mcl-1 inhibitors for the treatment of cancer

Johannes Belmar et al.

PHARMACOLOGY & THERAPEUTICS (2015)

Review Developmental Biology

The Fibroblast Growth Factor signaling pathway

David M. Ornitz et al.

WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Arylazopyrazole AAP1742 Inhibits CDKs and Induces Apoptosis in Multiple Myeloma Cells via Mcl-1 Downregulation

Radek Jorda et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2014)

Editorial Material Biochemistry & Molecular Biology

Apoptosis therapy: driving cancers down the road to ruin

Douglas R. Green et al.

NATURE MEDICINE (2013)

Article Biochemistry & Molecular Biology

Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase

Sang-Hyun Min et al.

MOLECULAR CELL (2012)

Article Biochemistry & Molecular Biology

Overexpression of microRNA-29b induces apoptosis of multiple myeloma cells through down regulating Mcl-1

Yi-Kun Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Multidisciplinary Sciences

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

Triona Ni Chonghaile et al.

SCIENCE (2011)

Article Hematology

Bortezomib restores stroma-mediated APO2L/TRAIL apoptosis resistance in multiple myeloma

Lia E. Perez et al.

EUROPEAN JOURNAL OF HAEMATOLOGY (2010)

Article Multidisciplinary Sciences

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

Martin Schwickart et al.

NATURE (2010)

Article Multidisciplinary Sciences

The landscape of somatic copy-number alteration across human cancers

Rameen Beroukhim et al.

NATURE (2010)

Article Biochemistry & Molecular Biology

Different forms of cell death induced by putative BCL2 inhibitors

M. Vogler et al.

CELL DEATH AND DIFFERENTIATION (2009)

Article Oncology

ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor

Christin Tse et al.

CANCER RESEARCH (2008)

Article Biochemistry & Molecular Biology

A pivotal role for Mcl-1 in Bortezomib-induced apoptosis

K. Podar et al.

ONCOGENE (2008)

Review Hematology

The malignant clone and the bone-marrow environment

Klaus Podar et al.

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2007)

Article Biochemistry & Molecular Biology

A novel Bcl-2/Bcl-XL/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma

D. Chauhan et al.

ONCOGENE (2007)

Review Hematology

Chemokines in multiple myeloma

Rohit Aggarwal et al.

EXPERIMENTAL HEMATOLOGY (2006)

Article Oncology

Immunomodulation of multiple myeloma

TM Tohnya et al.

CANCER BIOLOGY & THERAPY (2004)

Article Immunology

The imbalance between Bim and Mcl-1 expression controls the survival of human myeloma cells

P Gomez-Bougie et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2004)

Article Biochemistry & Molecular Biology

Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils

SJ Gardai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Immunology

Novel therapeutic approaches for multiple myeloma

T Hideshima et al.

IMMUNOLOGICAL REVIEWS (2003)

Article Medical Laboratory Technology

5′-OH-thalidomide, a metabolite of thalidomide, inhibits angiogenesis

DK Price et al.

THERAPEUTIC DRUG MONITORING (2002)

Article Biochemistry & Molecular Biology

Apaf-1/cytochrome c-independent and Smac-dependent induction of apoptosis in multiple myeloma (MM) cells

D Chauhan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)