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Current Practice in Carcinoid Heart Disease and Burgeoning Opportunities

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2022)

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Review Cardiac & Cardiovascular Systems

Carcinoid Heart Disease: Pathophysiology, Pathology, Clinical Manifestations, and Management

Chengyue Jin et al.

Summary: Carcinoid heart disease (CHD) is a rare and potentially lethal manifestation of advanced carcinoid tumors, primarily affecting right heart valves. Treatment involves controlling carcinoid syndrome, addressing valvular heart disease, and managing heart failure, with surgical valve replacement and catheter-directed procedures being potential options for some patients with CHD.

CARDIOLOGY (2021)

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Article Endocrinology & Metabolism

Managing carcinoid heart disease in patients with neuroendocrine tumors

Apostolos Koffas et al.

Summary: Carcinoid heart disease is a complex clinical entity associated with significant morbidity and mortality, frequently complicating the course of neuroendocrine tumors and carcinoid syndrome. The exposure to excessive circulating levels of serotonin is believed to play a key role in its pathogenesis. Treatment involves a multidisciplinary approach including watchful waiting, heart failure medications, optimal control of serotonin secretion, and in selected cases, cardiac valve replacement.

ANNALES D ENDOCRINOLOGIE (2021)

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Article Cardiac & Cardiovascular Systems

2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Catherine M. Otto et al.

Summary: Supplemental digital content is available in the text.

CIRCULATION (2021)

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Article Cardiac & Cardiovascular Systems

Transfemoral Transcatheter Tricuspid Valve Replacement With the EVOQUE System A Multicenter, Observational, First-in-Human Experience

Neil P. Fam et al.

Summary: This observational study on 25 patients undergoing EVOQUE TTVR for severe tricuspid regurgitation showed a technical success rate of 92%, 0% mortality at 30-day follow-up, and significant improvement in clinical symptoms for the patients.

JACC-CARDIOVASCULAR INTERVENTIONS (2021)

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Review Oncology

Carcinoid Heart Disease: a Review

Faidon-Marios Laskaratos et al.

Summary: Carcinoid heart disease, a fibrotic complication of neuroendocrine neoplasms, often goes unrecognized in patients. A multidisciplinary approach and strategic treatment may lead to improved outcomes for CHD patients.

CURRENT ONCOLOGY REPORTS (2021)

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Review Cardiac & Cardiovascular Systems

Classification of Heart Failure According to Ejection Fraction JACC Review Topic of the Week

Carolyn S. P. Lam et al.

Summary: The recent FDA approval for sacubitril/valsartan in heart failure introduces a new taxonomy, emphasizing potential benefit for patients with mid range ejection fraction. Sex differences are prominent, with women potentially benefiting at higher ejection fraction ranges.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Surgical aspects of valve replacement in carcinoid heart disease

Anders Albage et al.

Summary: Tricuspid and pulmonary valve replacement in patients with advanced carcinoid heart disease can reduce right heart failure and improve prognosis. While dedicated multidisciplinary care is necessary for these frail patients, optimization of surgical technique is crucial for better postoperative outcomes.

JOURNAL OF CARDIAC SURGERY (2021)

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Review Gastroenterology & Hepatology

Neuroendocrine liver metastases: a contemporary review of treatment strategies

Jordan M. Cloyd et al.

HEPATOBILIARY SURGERY AND NUTRITION (2020)

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Review Cardiac & Cardiovascular Systems

Cardiac Imaging in Carcinoid Heart Disease

Tomasz Baron et al.

JACC-CARDIOVASCULAR IMAGING (2020)

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Article Medicine, General & Internal

Transcatheter edge-to-edge repair for reduction of tricuspid regurgitation: 6-month outcomes of the TRILUMINATE single-arm study

Georg Nickenig et al.

LANCET (2019)

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Review Cardiac & Cardiovascular Systems

Diagnosing and Managing Carcinoid Heart Disease in Patients With Neuroendocrine Tumors An Expert Statement

Joseph Davar et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Article Medicine, General & Internal

Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors

J. Strosberg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Gastroenterology & Hepatology

The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Medical Management of Midgut Neuroendocrine Tumors

Jonathan R. Strosberg et al.

PANCREAS (2017)

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Letter Oncology

Challenging Management of Neuroendocrine Tumor With Hepatic Metastasis and Carcinoid Heart Disease in a Child

Sule Yesil et al.

PEDIATRIC BLOOD & CANCER (2016)

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Article Cardiac & Cardiovascular Systems

Transcatheter Pulmonary Valve Replacement in a Carcinoid Heart

Pranav Loyalka et al.

TEXAS HEART INSTITUTE JOURNAL (2016)

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Article Cardiac & Cardiovascular Systems

Transcatheter Pulmonary Valve Replacement in a Carcinoid Heart

Pranav Loyalka et al.

TEXAS HEART INSTITUTE JOURNAL (2016)

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Article Cardiac & Cardiovascular Systems

Early and Late Outcomes of Surgical Treatment in Carcinoid Heart Disease

Heidi M. Connolly et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

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Article Cardiac & Cardiovascular Systems

Eplerenone in systemic right ventricle: Double blind randomized clinical trial. The evedes study

Laura Dos et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2013)

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Editorial Material Cardiac & Cardiovascular Systems

Quadruple valve replacement in patients with carcinoid heart disease

Arman Arghami et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2010)

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Article Oncology

Placebo-Controlled, Double-Blind, Prospective, Randomized Study on the Effect of Octreotide LAR in the Control of Tumor Growth in Patients With Metastatic Neuroendocrine Midgut Tumors: A Report From the PROMID Study Group

Anja Rinke et al.

JOURNAL OF CLINICAL ONCOLOGY (2009)

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