Novel Nanotechnological Strategies for Skin Anti-aging

Background Nanoparticle formulations development for anti-aging treatment is increasingdue to their multifunctional properties. These nanotechnological strategies can target cellular/molecular pathways of the skin affected by the aging process. However, a review of these strategiesis required to discuss their efficacy/safety and establish the needs for further research.Objective: Innovative nanotechnological advances for skin anti-aging/rejuvenation are summarizedand discussed in this work. Methods The information in this review was extracted from recent and relevant studies usingnanotechnology for anti-aging treatment from scientific databases. Results and Discussion Results show an enhanced skin anti-aging effect of actives-loaded nanoparticlesof next generation (nanostructured lipid carriers, fullerenes, transfersomes, protransfersomes,niosomes, ethosomes, transethosomes, glycerosomes, phytosomes) compared withnanocarriers of first generation or conventional formulations. Anti-aging active ingredients such as,flavonoids (rutin, hesperidin, quercetagetine, quercetin, epigallocatechin-3-gallate, myricetin,silibinin, curcuminoids, isoflavones); vitamins (E, D3, CoQ10); acids (hyaluronic, ascorbic,rosmarinic, gallic); extracts (Citrus sinensis, Tagetes erecta L., Achillea millefolium L., Citrus aurantium L., Glycyrrhiza glabra L., Aloe vera, propolis earned by Apis mellifera); and othercompounds (adenosine, beta-glucan, heptapetide DEETGEF, resveratrol, cycloastragenol, melatonin,botulinum toxin, grapeseed oil), have been successfully entrapped into nanoparticles for skinrejuvenation. This encapsulation has improved their solubility, bioavailability, stability, permeability,and effectivity for skin anti-aging, providing a controlled drug release with minimized sideeffects. Conclusion Recent studies show a trend of anti-aging herbal active ingredients-loaded nanoparticles,enhancing the moisturizing, antioxidant, regenerating and photoprotective activity of the skin.Suitable safety/shelf-life stability of these novel formulations is key to a successful translation to theclinic/industry.

Automated summary

This article summarizes and discusses the innovative nanotechnological advances for skin anti-aging and rejuvenation. The study shows that the next generation nanoparticles have an enhanced anti-aging effect and successfully encapsulate various active ingredients for skin rejuvenation. These nanoparticles improve solubility, bioavailability, stability, permeability, and effectiveness, providing controlled drug release with minimized side effects.