4.5 Article

Safe and Rapid Synthesis and Utilization of 2-Azidopyridine and Related Derivatives via Continuous Flow Diazotization

期刊

CURRENT ORGANIC CHEMISTRY
卷 26, 期 24, 页码 2223-2229

出版社

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272827666230126141058

关键词

Flow chemistry; N-heterocycles; aril azides; in-line extraction; azide-tetrazole tautomerism; diazotization; safety

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Aril azides are commonly used in laboratories but their explosive properties limit their application on a larger scale. Flow chemistry provides a safer method for the synthesis and utilization of dangerous and explosive chemicals. This study successfully achieved the safe syntheses of various derivatives within a continuous-flow system.
Aril azides are popular reagents in the laboratory, but their explosive properties prevent their larger-scale application. The safety risk is even greater for N-heterocyclic azides, which are rarely studied. Flow chemistry can be an effective tool in the synthesis and utilization of dangerous and explosive chemicals. In small-diameter flow reactors, good heat and mass transfer prevent local hot spots and side reactions, and since only small amounts of hazardous chemicals are present at any time, the potential danger is reduced in the event of an accident. In this work, the safe syntheses of 9 different 2-azidopyridine, 2-azidopyrimidine and 2-azidoquinoxaline derivatives were successfully achieved within the continuous-flow system. In most cases, simple work-up resulted in pure products. In-line extractive work-up was also implemented, which allowed us to transform 2-azidopyridine in a subsequent Staudinger reaction in a connected flow reactor, without manual handling of the hazardous azide.

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