期刊
CURRENT ORGANIC CHEMISTRY
卷 26, 期 24, 页码 2151-2159出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272827666230201103848
关键词
beta-nicotinamide mononucleotide; beta-NMN; NAD(+); food ingredient; nutritional supplementation; chemical synthesis; large-scale application
资金
- National Natural Science Foundation of China [21602164, 21877087]
- Natural Science Foundation of Hubei Province [2020CFB623, 2021CFB556]
- Key Laboratory for Green Chemical Process of Ministry of Education Open Fund [GCP20200201]
- Hubei Key Laboratory of Novel Reactor and Green Chemical Technology (Wuhan Institute of Technology) Open Fund [40201002]
- Wuhan Institute of Technology Graduate Education and Teaching Reform Research Project [2021JYXM07, 2022JYXM09, 2022JYXM16]
This review summarizes recent developments in the chemical synthesis of β-NMN from various starting materials, providing valuable references for the investigation of new synthetic techniques and the further development and large-scale application of β-NMN.
b-Nicotinamide mononucleotide (beta-NMN), a key precursor in the biosynthesis of nicotinamide adenine dinucleotide (NAD(+)) in mammals, has significant effects in replenishing NAD(+) levels in the body, so it has obvious ameliorative effects on metabolic and age-related degenerative diseases. beta-NMN is widely used in healthcare products, food, and cosmetics. It has considerable commercial worth and promising medical application prospects. Hence, the development of methods for preparing beta-NMN is of great research significance. This review summarized and analyzed recent developments in the chemical synthesis of beta-NMN from various starting materials, which could provide helpful references for the investigation of new synthetic techniques for beta-NMN and encourage its further development and large-scale application.
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