期刊
CURRENT OPINION IN MICROBIOLOGY
卷 70, 期 -, 页码 -出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2022.102230
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资金
- INCEPTION project [ANR-10-LABX-62-IBEID]
- Equipe Fondation pour la Recherche Medicale [EQU201903007835]
- Laboratoire d Excellence IBEID Integrative Biology of Emerging Infectious Diseases [PIA/ANR-16-CONV-0005]
Interactions between viruses, cells, and other genetic elements play a crucial role in the success of infections. These interactions can involve antagonism, competition, cooperation, or parasitism. Rapid evolution through genetic exchanges and functional diversification shapes multilayered networks of interactions that determine the outcome of viral infections.
Studies of viral adaptation have focused on the selective pressures imposed by hosts. However, there is increasing evidence that interactions between viruses, cells, and other mobile genetic elements are determinant to the success of infections. These interactions are often associated with antagonism and competition, but sometimes involve cooperation or parasitism. We describe two key types of interactions - defense systems and genetic regulation - that allow the partners of the interaction to destroy or control the others. These interactions evolve rapidly by genetic exchanges, including among competing partners. They are sometimes followed by functional diversification. Gene exchanges also facilitate the emergence of cross-talk between elements in the same bacterium. In the end, these processes produce multilayered networks of interactions that shape the outcome of viral infections.
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