4.5 Review

Taming glutathione potentiates metallodrug action

期刊

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2022.102213

关键词

Glutathione; Metallodrugs; Drug resistance; Toxicity; Metals in medicine

资金

  1. Welch Foundation
  2. National Institute of General Medical Sciences of the National Institutes of Health
  3. [E-1894]
  4. [R01GM129276]

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This review presents the general approaches for taming glutathione in metallodrug therapy and discusses their strengths and limitations. The perspectives on developing practical solutions that are effective and clinically relevant are also offered.
Metallodrugs that are redox sensitive or have labile coordina-tion sites are particularly susceptible to inhibition by gluta-thione (GSH) and other endogenous thiols. Because GSH is an essential antioxidant, strategies to prevent thiol deactivation must consider their potential effects on normal cellular func-tions. In this short review, we describe general approaches for taming glutathione in metallodrug therapy and discuss their strengths and limitations. We also offer our perspectives on developing practical solutions that are effective and clinically relevant.

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