相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems
Renke Tan et al.
MOLECULAR CELL (2022)
Structural basis for mismatch surveillance by CRISPR-Cas9
Jack P. K. Bravo et al.
NATURE (2022)
Structural biology of CRISPR-Cas immunity and genome editing enzymes
Joy Y. Wang et al.
NATURE REVIEWS MICROBIOLOGY (2022)
CRISPR-Cas9 bends and twists DNA to read its sequence
Joshua C. Cofsky et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2022)
Structural rearrangements allow nucleic acid discrimination by type I-D Cascade
Evan A. Schwartz et al.
NATURE COMMUNICATIONS (2022)
Dynamics and mechanisms of CRISPR-Cas9 through the lens of computational methods
Aakash Saha et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2022)
Structural basis for Cas9 off-target activity
Martin Pacesa et al.
CELL (2022)
R-loop formation and conformational activation mechanisms of Cas9
Martin Pacesa et al.
NATURE (2022)
Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
Stephen K. Jones et al.
NATURE BIOTECHNOLOGY (2021)
CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia
H. Frangoul et al.
NEW ENGLAND JOURNAL OF MEDICINE (2021)
CRISPR technologies and the search for the PAM-free nuclease
Daphne Collias et al.
NATURE COMMUNICATIONS (2021)
Engineering Cas9 for human genome editing
Ian M. Slaymaker et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2021)
CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis
Julian D. Gillmore et al.
NEW ENGLAND JOURNAL OF MEDICINE (2021)
CRISPR TREATMENT INSERTED DIRECTLY INTO BODY FOR THE FIRST TIME
Heidi Ledford
NATURE (2020)
Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches
Majda Bratovic et al.
NATURE CHEMICAL BIOLOGY (2020)
Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants
Kira S. Makarova et al.
NATURE REVIEWS MICROBIOLOGY (2020)
Allosteric regulation of CRISPR-Cas9 for DNA-targeting and cleavage
Zhicheng Zuo et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2020)
Prediction of the sequence-specific cleavage activity of Cas9 variants
Nahye Kim et al.
NATURE BIOTECHNOLOGY (2020)
A compact Cascade-Cas3 system for targeted genome engineering
Balint Csoergo et al.
NATURE METHODS (2020)
Diverse CRISPR-Cas Complexes Require Independent Translation of Small and Large Subunits from a Single Gene
Tess M. McBride et al.
MOLECULAR CELL (2020)
Structural basis for assembly of non-canonical small subunits into type I-C Cascade
Roisin E. O'Brien et al.
NATURE COMMUNICATIONS (2020)
Catalytic Mechanism of Non-Target DNA Cleavage in CRISPR-Cas9 Revealed by Ab Initio Molecular Dynamics
Lorenzo Casalino et al.
ACS CATALYSIS (2020)
Structure Reveals a Mechanism of CRISPR-RNA-Guided Nuclease Recruitment and Anti-CRISPR Viral Mimicry
MaryClare F. Rollins et al.
MOLECULAR CELL (2019)
Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics
Clarisse G. Ricci et al.
ACS CENTRAL SCIENCE (2019)
Cryo-EM structures reveal coordinated domain motions that govern DNA cleavage by Cas9
Xing Zhu et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)
Harnessing type I CRISPR-Cas systems for genome engineering in human cells
Peter Cameron et al.
NATURE BIOTECHNOLOGY (2019)
CRISPR/Cas9 searches for a protospacer adjacent motif by lateral diffusion
Viktorija Globyte et al.
EMBO JOURNAL (2019)
CRISPR-Cas3 induces broad and unidirectional genome editing in human cells
Hiroyuki Morisaka et al.
NATURE COMMUNICATIONS (2019)
Target Specificity of Cas9 Nuclease via DNA Rearrangement Regulated by the REC2 Domain
Keewon Sung et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Repetitive DNA Reeling by the Cascade-Cas3 Complex in Nucleotide Unwinding Steps
Luuk Loeff et al.
MOLECULAR CELL (2018)
Mechanisms of improved specificity of engineered Cas9s revealed by single-molecule FRET analysis
Digvijay Singh et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Mechanisms of improved specificity of engineered Cas9s revealed by single-molecule FRET analysis
Digvijay Singh et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
DNA Unwinding Is the Primary Determinant of CRISPR-Cas9 Activity
Shanzhong Gong et al.
CELL REPORTS (2018)
Key role of the REC lobe during CRISPR-Cas9 activation by 'sensing', 'regulating', and 'locking' the catalytic HNH domain
Giulia Palermo et al.
QUARTERLY REVIEWS OF BIOPHYSICS (2018)
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy
Janice S. Chen et al.
NATURE (2017)
Class 2 CRISPR-Cas RNA-guided endonucleases: Swiss Army knives of genome editing
Stefano Stella et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations
Giulia Palermo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Kinetics of dCas9 target search in Escherichia coli
Daniel Lawson Jones et al.
SCIENCE (2017)
Class 2 CRISPR-Cas RNA-guided endonucleases: Swiss Army knives of genome editing
Stefano Stella et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
Molecular architectures and mechanisms of Class 2 CRISPR-associated nucleases
Carmela Garcia-Doval et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2017)
Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System
Yibei Xiao et al.
CELL (2017)
Rationally engineered Cas9 nucleases with improved specificity
Ian M. Slaymaker et al.
SCIENCE (2016)
The discovery of CRISPR in archaea and bacteria
Francisco J. M. Mojica et al.
FEBS JOURNAL (2016)
DNA Targeting by a Minimal CRISPR RNA-Guided Cascade
Megan L. Hochstrasser et al.
MOLECULAR CELL (2016)
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
Benjamin P. Kleinstiver et al.
NATURE (2016)
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
Fuguo Jiang et al.
SCIENCE (2016)
Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9
Digvijay Singh et al.
NATURE COMMUNICATIONS (2016)
CRISPR-Cas9 for in vivo Gene Therapy: Promise and Hurdles
Wei-Jing Dai et al.
Molecular Therapy-Nucleic Acids (2016)
Cryo-EM: A Unique Tool for the Visualization of Macromolecular Complexity
Eva Nogales et al.
MOLECULAR CELL (2015)
Conformational control of DNA target cleavage by CRISPR-Cas9
Samuel H. Sternberg et al.
NATURE (2015)
A Cas9-guide RNA complex preorganized for target DNA recognition
Fuguo Jiang et al.
SCIENCE (2015)
Dynamics of CRISPR-Cas9 genome interrogation in living cells
Spencer C. Knight et al.
SCIENCE (2015)
Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
Carolin Anders et al.
NATURE (2014)
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
Samuel H. Sternberg et al.
NATURE (2014)
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
Martin Jinek et al.
SCIENCE (2014)
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
Vikram Pattanayak et al.
NATURE BIOTECHNOLOGY (2013)
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali et al.
SCIENCE (2013)
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong et al.
SCIENCE (2013)
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
Giedrius Gasiunas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jinek et al.
SCIENCE (2012)
分享论文
