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Migraine and Gastroparesis

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2022)

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Article Clinical Neurology

The prevalence and characteristics of visceral autonomic symptoms among migraineurs: A population-based study

Mansoureh Togha et al.

Summary: Visceral symptoms are common in migraine sufferers not only during attacks but also in the premonitory and postdrome phases; Participants with visceral symptoms experience longer and more severe migraine attacks compared to those without symptoms.

CEPHALALGIA (2022)

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Article Gastroenterology & Hepatology

Epidemiology, Etiology, and Treatment of Gastroparesis: Real-World Evidence From a Large US National Claims Database

Yizhou Ye et al.

Summary: This study utilized a large US claims database to investigate the prevalence, patient demographics, and disease etiology of gastroparesis in the US population. It found that diabetes was the most common etiology of gastroparesis and patients had a high comorbidity burden. Wider availability of objective gastric emptying measures and education for medical professionals are needed to improve understanding of gastroparesis epidemiology.

GASTROENTEROLOGY (2022)

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Review Biotechnology & Applied Microbiology

Harnessing Intranasal Delivery Systems of Sumatriptan for the Treatment of Migraine

Sara Assadpour et al.

Summary: This study reviews novel delivery systems for intranasal administration of sumatriptan, a commonly prescribed drug for migraine treatment. The oral route of administration has complications, and intranasal administration has been shown to be fast-acting and effective. The use of new delivery systems can improve the bioavailability and effectiveness of sumatriptan. However, further clinical studies are necessary.

BIOMED RESEARCH INTERNATIONAL (2022)

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Review Gastroenterology & Hepatology

AGA Clinical Practice Update on Management of Medically Refractory Gastroparesis: Expert Review

Brian E. Lacy et al.

Summary: This article outlines a strategy for defining, diagnosing, and managing refractory gastroparesis, including evaluating symptoms and physical examination findings, verifying the accuracy of gastric emptying studies, classifying patients based on symptoms and study results, and initiating treatment based on the predominant symptom.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Long-term Outcome of Gastric Per-Oral Endoscopic Pyloromyotomy in Treatment of Gastroparesis

Mohamed M. Abdelfatah et al.

Summary: A retrospective analysis of 90 patients who underwent GPOEM for refractory gastroparesis showed that 81.1% had a clinical response at initial follow-up. One year after GPOEM, 69.1% of all patients had a clinical response and 85.2% of initial responders maintained a clinical response. Patients maintained a clinical response and improved quality of life for as long as 3 years after the procedure, with high BMI and long duration gastroparesis associated with failure of GPOEM.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Article Clinical Neurology

The prevalence and impact of migraine and severe headache in the United States: Updated age, sex, and socioeconomic-specific estimates from government health surveys

Rebecca Burch et al.

Summary: Accurate estimates of the burden of migraine and severe headache are crucial for evidence-based decision-making about workforce needs and health resource distribution. The prevalence of migraine in the US has remained stable, with a higher impact in women of childbearing age and those of lower socioeconomic status. Many adults with migraine or severe headaches are disadvantaged, highlighting the need for improved funding for treatment provision and research to reduce the future burden of disease.

HEADACHE (2021)

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Article Anesthesiology

Predominant role of gut-vagus-brain neuronal pathway in postoperative nausea and vomiting: evidence from an observational cohort study

Nana Li et al.

Summary: By comparing patients undergoing different surgical procedures, it was found that those who underwent vagotomy had a lower incidence of PONV, suggesting that gut-brain signaling via the vagus nerve may play a predominant role in PONV.

BMC ANESTHESIOLOGY (2021)

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Review Clinical Neurology

A link between gastrointestinal disorders and migraine: Insights into the gut-brain connection

Sheena K. Aurora et al.

Summary: Migraine and gastrointestinal disorders share a common etiology, with delayed gastric emptying, functional dyspepsia, and CVS being associated with migraine and impacting treatment. Recognition of gastrointestinal disorders in migraine patients is important for improving treatment outcomes.

HEADACHE (2021)

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Review Pharmacology & Pharmacy

Intranasal metoclopramide for acute and recurrent diabetic gastroparesis in adults

Devada Singh-Franco et al.

Summary: Metoclopramide nasal spray has shown effectiveness in treating diabetic gastroparesis, especially in female patients. Adverse events are mild to moderate, and further research is needed to evaluate its efficacy, tolerability, and cost-effectiveness.

DRUGS & THERAPY PERSPECTIVES (2021)

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Article Clinical Neurology

STOP 301: A Phase 3, open-label study of safety, tolerability, and exploratory efficacy of INP104, Precision Olfactory Delivery (POD(R)) of dihydroergotamine mesylate, over 24/52 weeks in acute treatment of migraine attacks in adult patients

Timothy R. Smith et al.

Summary: INP104 showed good safety and efficacy in treating migraine in the STOP 301 trial, with most patients satisfied with its use. The drug has the potential to be a promising treatment for acute migraine episodes.

HEADACHE (2021)

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Review Medicine, General & Internal

Acute Treatments for Episodic Migraine in Adults: A Systematic Review and Meta-analysis

Juliana H. VanderPluym et al.

Summary: This study found that multiple acute treatments for migraine were associated with improvements in short-term pain outcomes, but evidence for interventions such as opioids was limited.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Clinical Neurology

A Phase 1, Randomized, Open-Label, Safety, Tolerability, and Comparative Bioavailability Study of Intranasal Dihydroergotamine Powder (STS101), Intramuscular Dihydroergotamine Mesylate, and Intranasal DHE Mesylate Spray in Healthy Adult Subjects

Detlef Albrecht et al.

HEADACHE (2020)

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Article Gastroenterology & Hepatology

Open-label pilot study: Non-invasive vagal nerve stimulation improves symptoms and gastric emptying in patients with idiopathic gastroparesis

Andres Gottfried-Blackmore et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2020)

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Letter Medicine, Research & Experimental

Noninvasive Vagus Nerve Stimulation for Nausea Prevention During BPPV Treatment

Shin C. Beh

NEUROMODULATION (2020)

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Review Gastroenterology & Hepatology

Pathophysiology, Aetiology and Treatment of Gastroparesis

A. Sullivan et al.

DIGESTIVE DISEASES AND SCIENCES (2020)

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Article Clinical Neurology

Two-Hour CGRP Infusion Causes Gastrointestinal Hyperactivity: Possible Relevance for CGRP Antibody Treatment

Katrine Falkenberg et al.

HEADACHE (2020)

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Review Clinical Neurology

Gepants, calcitonin-gene-related peptide receptor antagonists: what could be their role in migraine treatment?

David Moreno-Ajona et al.

CURRENT OPINION IN NEUROLOGY (2020)

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Review Clinical Neurology

Greater occipital nerve block in migraine prophylaxis: Narrative review

Levent Ertugrul Inan et al.

CEPHALALGIA (2019)

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Review Gastroenterology & Hepatology

Role of Gastric Emptying in Symptoms of Gastroparesis

Asad Jehangir et al.

GASTROINTESTINAL DISORDERS (2019)

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Article Clinical Neurology

AVP-825 (Sumatriptan Nasal Powder) Reduces Nausea Compared to Sumatriptan Tablets: Results of the COMPASS Randomized Clinical Trial

Richard B. Lipton et al.

HEADACHE (2018)

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Review Clinical Neurology

A Phase-by-Phase Review of Migraine Pathophysiology

David W. Dodick

HEADACHE (2018)

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Review Medicine, General & Internal

Migraine

David W. Dodick

LANCET (2018)

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Article Medicine, General & Internal

Gastroparesis

Michael Camilleri et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

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Review Engineering, Biomedical

Breath-powered sumatriptan dry nasal powder: an intranasal medication delivery system for acute treatment of migraine

Stewart J. Tepper et al.

MEDICAL DEVICES-EVIDENCE AND RESEARCH (2018)

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Review Clinical Neurology

Botulinum toxin in the management of chronic migraine: clinical evidence and experience

Claus M. Escher et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2017)

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Review Gastroenterology & Hepatology

Gastroparesis Updates on Pathogenesis and Management

Nanlong Liu et al.

GUT AND LIVER (2017)

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Article Neurosciences

Vagus nerve stimulation suppresses acute noxious activation of trigeminocervical neurons in animal models of primary headache

Simon Akerman et al.

NEUROBIOLOGY OF DISEASE (2017)

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Article Gastroenterology & Hepatology

Proof of concept: short-term non-invasive cervical vagus nerve stimulation in patients with drug-refractory gastroparesis

Emma Paulon et al.

FRONTLINE GASTROENTEROLOGY (2017)

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Article Gastroenterology & Hepatology

Gastroduodenal Disorders

Vincenzo Stanghellini et al.

GASTROENTEROLOGY (2016)

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Article Gastroenterology & Hepatology

Diabetic Gastroparesis

Kenneth L. Koch et al.

GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2015)

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Article Gastroenterology & Hepatology

Clinical Presentation and Pathophysiology of Gastroparesis

Linda Anh Nguyen et al.

GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2015)

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Article Clinical Neurology

Triptans in the Acute Treatment of Migraine: A Systematic Review and Network Meta-Analysis

Chris Cameron et al.

HEADACHE (2015)

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Article Clinical Neurology

Treatment of chronic migraine with transcutaneous stimulation of the auricular branch of the vagal nerve (auricular t-VNS): a randomized, monocentric clinical trial

Andreas Straube et al.

JOURNAL OF HEADACHE AND PAIN (2015)

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Article Clinical Neurology

The origin of nausea in migraine-A PET study

Farooq H. Maniyar et al.

JOURNAL OF HEADACHE AND PAIN (2014)

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Review Clinical Neurology

Gastric stasis in migraineurs: Etiology, characteristics, and clinical and therapeutic implications

Sheena K. Aurora et al.

CEPHALALGIA (2013)

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Article Clinical Neurology

Migraine and Gastroparesis From a Gastroenterologist's Perspective

Henry P. Parkman

HEADACHE (2013)

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Article Medicine, General & Internal

Changes in liquid emptying in migraine patients: diagnosed with liquid phase gastric emptying scintigraphy

H. Yalcin et al.

INTERNAL MEDICINE JOURNAL (2012)

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Article Respiratory System

Nasal Deposition and Clearance in Man: Comparison of a Bidirectional Powder Device and a Traditional Liquid Spray Pump

Per Gisle Djupesland et al.

JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY (2012)

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Article Gastroenterology & Hepatology

Gastric Emptying in Migraine: A Comparison With Functional Dyspepsia

Yeon Hwa Yu et al.

JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY (2012)

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Article Gastroenterology & Hepatology

Cellular Changes in Diabetic and Idiopathic Gastroparesis

Madhusudan Grover et al.

GASTROENTEROLOGY (2011)

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Review Clinical Neurology

Why pharmacokinetic differences among oral triptans have little clinical importance: a comment

Anna Ferrari et al.

JOURNAL OF HEADACHE AND PAIN (2011)

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Editorial Material Clinical Neurology

Dopamine: what's new in migraine?

Annabelle R. Charbit et al.

CURRENT OPINION IN NEUROLOGY (2010)

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Review Clinical Neurology

CGRP and its receptors provide new insights into migraine pathophysiology

Tony W. Ho et al.

NATURE REVIEWS NEUROLOGY (2010)

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Review Gastroenterology & Hepatology

Consensus Recommendations for Gastric Emptying Scintigraphy: A Joint Report of the American Neurogastroenterology and Motility Society and the Society of Nuclear Medicine

Thomas L. Abell et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2008)

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Article Clinical Neurology

Brainstem dysfunction in chronic migraine as evidenced by neurophysiological and positron emission tomography studies

Sheena K. Aurora et al.

HEADACHE (2007)

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Article Clinical Neurology

Gastric stasis in migraine: More than just a paroxysmal abnormality during a migraine attack

SK Aurora et al.

HEADACHE (2006)

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Review Clinical Neurology

Mechanisms of action of the 5-HT1B/1D receptor agonists

SJ Tepper et al.

ARCHIVES OF NEUROLOGY (2002)

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Article Gastroenterology & Hepatology

Extending gastric emptying scintigraphy from two to four hours detects more patients with gastroparesis

JP Guo et al.

DIGESTIVE DISEASES AND SCIENCES (2001)

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