One-dimensional Polymeric Nanocomposites in Drug Delivery Systems

Nanocomposites have become a promising approach for drug delivery in the pharmaceutical field due to several benefits and current research development. Polymer nanocomposites (PNCs) are blends of nanomaterials and polymers with at least one-dimensional structure and one component in the sub-100 nm range. By incorporating nanoparticles into the polymer matrix, it is feasible to create a new class of given characteristics. Nano-clay (a type of nanocomposite) is mainly used for the controlled release of therapeutics in various disease conditions. Nanocomposites are promising drug delivery systems due to several advantages, including surface and rheological characteristics. Considering physical and chemical properties, nanocomposites are divided into two different components. Polymer-fabricated nanocomposites are potentially used in multi-particulate systems, which results in a controlled drug release profile with improved mechanical integrity. Nanotechnology-based drug delivery nanocomposites offer an improved half-life, greater biocompatibility, minimum immunogenicity, site-specific targeting, and avoid membrane barriers. Specifically, one-dimensional (1D) nanocomposites show promising responses in theranostics due to improved surface area-to-volume ratios that offer specific targeting, improved encapsulation efficiency, and susceptibility to biomolecules.

Automated summary

Nanocomposites have emerged as a promising strategy for drug delivery in the pharmaceutical field, offering numerous benefits and ongoing research development. Polymer nanocomposites (PNCs) are blends of nanomaterials and polymers, where at least one component has a one-dimensional structure and falls within the sub-100 nm range. By incorporating nanoparticles into the polymer matrix, a new class of drug delivery systems with specific characteristics can be created. Nano-clay, a type of nanocomposite, is predominantly utilized for controlled release of therapeutics in various disease conditions. Nanocomposites hold great potential as drug delivery systems due to advantages such as surface and rheological characteristics. Considering their physical and chemical properties, nanocomposites can be categorized into two distinct components. Polymer-fabricated nanocomposites hold potential for use in multi-particulate systems, resulting in controlled drug release profiles with improved mechanical integrity. Nanotechnology-based drug delivery nanocomposites offer benefits including enhanced half-life, greater biocompatibility, reduced immunogenicity, site-specific targeting, and overcoming membrane barriers. Particularly, one-dimensional (1D) nanocomposites exhibit promising potential in theranostics, owing to their increased surface area-to-volume ratios, enabling specific targeting, enhanced encapsulation efficiency, and susceptibility to biomolecules.