期刊
CURRENT DRUG METABOLISM
卷 23, 期 14, 页码 1124-1129出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389200224666230109162132
关键词
Vitamin D; COVID-19; clinical laboratory services; prognosis; T lymphocytes; serum concentration
This study aims to assess the levels of vitamin D in patients with COVID-19 and determine if these levels are sufficient to protect against disease progression.
Introduction and Aim Vitamin D is the name given to a group of lipid-soluble steroidal substances of physiological importance in the body, especially in bone metabolism. The active form of vitamin D is believed to have immunomodulatory effects on immune system cells, especially T lymphocytes, as well as on the production and action of several cytokines and on the expression of potent antimicrobial peptides in epithelial cells that line the respiratory tract, playing an important role in protecting the lung from infections. The aim of this study was to assess vitamin D levels in patients with COVID-19 in healthcare service and to verify that these levels are adequate to protect the progression of this infection. Methods The aim of this observational study was to evaluate the serum concentration of vitamin D in 300 patients suspected of being infected with COVID-19, treated at Basic Health Units (BHUs) and at the Hospital Complex in the municipality of Sao Bernardo do Campo. Results 294 patients were included, 195 (66%) of which tested positive for COVID-19 and 99 (34%) negative for COVID-19. Among the patients in the positive group, 163 patients were in the mild group (84%); 22 patients in the moderate group (11%); 8 patients in the severe group (4%), and 2 patients in the deceased group (1%). Conclusion For the patients in this study, no association was observed for the protective factor of vitamin D against COVID-19 infection, and its role in controlling the clinical staging of the disease was not verified.
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