Analytical Methods for the Determination of Atypical Antipsychotic Drugs-An Update

Atypical antipsychotics have gained incredible attention over the last decade and are widely prescribed for short-term and chronic treatment of various psychopathological diseases, including schizophrenia, mania, delirium, bipolar disorder, depression, autism spectrum disorder, and affective disorders. Due to their better clinical profile and therapeutic benefits, atypical antipsychotics have become a better choice for psychopathological treatment and management. However, their usage is associated with peripheral side effects and metabolic diseases impacting the quality of life of patients. In the sight of these circumstances, strategic development of analytical methods to isolate atypical antipsychotics from a variety of formulations and biological samples and identify and quantify them with great sensitivity and accuracy is of great importance in clinical and forensic settings. In the present review, we have summarized and discussed various analytical methods reported in the literature over the last decade in various formulations and biological samples, highlighting analytical trends to the analysts in the field of atypical antipsychotics.

Automated summary

Atypical antipsychotics have become popular for treating various psychopathological diseases in the past decade due to their better clinical profile and therapeutic benefits. However, their usage can lead to peripheral side effects and metabolic diseases, impacting patients' quality of life. Therefore, developing analytical methods to accurately identify and quantify these drugs from different formulations and biological samples is crucial in clinical and forensic settings.