Metaplastic breast cancer: A review

Metaplastic breast cancer (MpBC) is an uncommon aggressive malignancy that is associated with a poor prognosis. Due to its rarity, the relationships between the clinical and pathological features of MpBC, treatment approach, and clinical outcomes remain underexplored. In the following review article, we synthesize the existing data on the clinical, pathological and genomic features, management, and outcomes of MpBC. We also identify potential targets for future clinical trials.

Automated summary

Metaplastic breast cancer (MpBC) is a rare aggressive malignancy with poor prognosis. The relationships between clinical and pathological features, treatment approach, and outcomes of MpBC remain underexplored. In this review article, existing data on MpBC regarding clinical, pathological and genomic features, management, and outcomes are synthesized, and potential targets for future clinical trials are identified.