期刊
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
卷 180, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2022.103849
关键词
LncRNA; Blood cells; Biological function; Mechanism; Hematological malignancies
资金
- Shandong Provincial Natural Science Foundation [ZR2021MH082]
- National Natural Science Foundation of China [81670398, 81801192, 91639102]
- Taishan Scholars of Shandong Province
Long non-coding RNA (LncRNA) is a class of non-coding RNA with more than 200 nucleotides, widely involved in biological processes and associated with the occurrence and development of various diseases. Studies have revealed the crucial role of LncRNA in red blood cell development and the pathogenesis of hematological malignancies.
Long non-coding RNA (LncRNA) is a class of non-coding RNA comprising more than 200 nucleotides. Several studies report that LncRNAs are widely involved in biological processes such as DNA methylation, histone modification, and chromatin remodeling. LncRNA interacts with DNA, RNA, and protein molecules thus regulating expression of target genes. LncRNAs are associated with occurrence and development of tumors, nervous systems, metabolic diseases, reproductive development, and cardiovascular diseases. Therefore, LncRNAs are implicated in progression of several diseases. Studies report that LncRNA plays a crucial role in regulation of gene expression during proliferation and differentiation stages of red blood cell development. LncRNA promotes development of hematopoietic stem cells and plays an important role in myeloid and lymphatic function. In this paper, studies on regulatory mechanism of LncRNA in blood cells and pathogenesis in hematological malignancies were reviewed.
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