期刊
CORNEA
卷 42, 期 11, 页码 1355-1359出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ICO.0000000000003234
关键词
meibomian gland atrophy; dry eye disease; meibomian gland dysfunction; meibography
This study aimed to determine the prevalence of meibomian gland (MG) atrophy in US-based cataract surgery patients. The results showed that 95.1% of the 391 patients had MG atrophy, with 50.4% having grade 1, 25.8% grade 2, and 18.9% grade 3. The study suggests that MG atrophy is common in patients undergoing cataract surgery and calls for the routine use of meibography during preoperative screening.
Purpose: The aim of this study was to determine the prevalence of meibomian gland (MG) atrophy in a US-based population of patients presenting for cataract surgery.Methods: In this retrospective study, case records of 391 patients aged 50 years or older, who had undergone a preoperative cataract surgery workup with meibography, were included. The amount of atrophy in the lower eyelid was graded as described by Arita et al (grade 0 = no atrophy, grade 1 = 1%-33% atrophy, grade 2 = 34%-66% atrophy, and grade 3 = >66% atrophy), and the prevalence of MG atrophy was determined. Associations between MG atrophy and demography, comorbidities, and risk factors were evaluated.Results: Overall, 95.1% of patients (372/391) had MG atrophy >= grade 1, with 50.4% (197/391) having grade 1, 25.8% (101/391) grade 2, and 18.9% (74/391) grade 3. MG atrophy had a statistically significant correlation with MG expressibility (R = 0.22; P = 0.001), but not with meibum grade (R = 0.103; P = 0.123) and telangiectasia (R = 0.014; P = 0.787). The prevalence of MG atrophy (>= grade 1) was comparable among patients who had previously been diagnosed with dry eye disease (DED) versus those who had not; however, the severity of MG atrophy was higher in patients with previous DED diagnosis (grade 2/3: 59% vs. 30.9%). Among patients with no previous history of DED, 18% (35/194) had moderate and 13% (25/194) had severe MG atrophy.Conclusions: MG atrophy is common in patients presenting for cataract surgery evaluation, indicating potential underdiagnosis. Routine use of meibography during preoperative screening in cataract surgery patients may facilitate more timely and effective diagnosis and treatment.
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