期刊
COORDINATION CHEMISTRY REVIEWS
卷 474, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2022.214857
关键词
Amino acids; Metal complexes; Multinuclear structures; Cysteine; Penicillamine
Thiol-containing amino acids have been extensively studied as chelating ligands, forming coordination compounds with various metal elements and exhibiting a capacity to form multinuclear structures. Recent research has demonstrated that the use of metal complexes with thiol-containing amino acids allows for the selective introduction of secondary metal ions, enabling the rational design of multinuclear and metallosupramolecular coordination compounds.
Thiol-containing amino acids have been known to act as chelating ligands with three potential coordina-tion sites: thiol, amine, and carboxyl groups. Since early reports on the iron-catalyzed oxidation of cys-teine in 1884 and the copper-chelating therapy of D-penicillamine in 1956, more than 200 coordination compounds with thiol-containing amino acids have been developed and structurally char-acterized. The co-presence of hard (amine and carboxylate) and soft (thiolate) Lewis bases in the ligands enables them to bind to most metallic elements ranging from Group 3 to Group 15 in various coordina-tion modes. In addition, the presence of a thiolate group leads to the formation of multinuclear structural motifs with sulfur bridges in this family of coordination compounds. Notably, the recent development of a metalloligand approach using isolated metal complexes with thiol-containing amino acids, which con-tain available coordination sites for secondary metal ions, has contributed to the rational creation of a variety of multinuclear and metallosupramolecular coordination compounds. This review provides an overview of the synthesis, structures, and properties of coordination compounds derived from thiol-containing amino acids, focusing on cysteine and penicillamine as multifunctional ligands. (c) 2022 Elsevier B.V. All rights reserved.
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