Recent advances on organelle specific Ru(II)/Ir(III)/Re(I) based complexes for photodynamic therapy

Organelle specificity is an important facet of more efficient and highly selective drugs with reduced side effects which have now been the great challenge to the scientists. In eradication of lethality of cancer, the appropriate anticancer therapeutics should render less toxicity towards the normal healthy cells. Therefore, in present scenario the application of photodynamic therapy (PDT) in healing cancer has brought about a renaissance in the field of anticancer research as PDT is very selective treatment proce-dure under irradiation of localized light at a particular portion of the body without creating any photo -toxic damage to the normal cells. Metal complexes, especially ruthenium (II), iridium (III) and rhenium (I) complexes have been seen to be highly apt for PDT. Hence, a bucket of Ru (II), Ir (III) and Re (I) based var-ious types of complexes have been showcased here mentioning their capability to target specific orga-nelle along with the detailed discussion on pathway of photodynamic therapy.(c) 2022 Elsevier B.V. All rights reserved.

Automated summary

Organelle specificity is crucial for the development of efficient and selective drugs with reduced side effects. Photodynamic therapy (PDT) has emerged as a selective treatment for cancer that minimizes damage to normal cells. This article showcases the potential of metal complexes, particularly ruthenium (II), iridium (III), and rhenium (I) complexes, in targeting specific organelles for PDT.