期刊
COMPLEMENTARY THERAPIES IN MEDICINE
卷 71, 期 -, 页码 -出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ctim.2022.102881
关键词
Dietary phytochemical index; DPI; Non-alcoholic fatty liver disease; NAFLD
资金
- Shahid Beheshti University of Medical Sciences, Tehran, Iran [1399/64283]
A higher dietary phytochemical index (DPI) is associated with a reduced chance of non-alcoholic fatty liver disease (NAFLD) according to a case-control study. Specifically, the highest tertile of vegetable and olives PI is significantly associated with a lower risk of NAFLD.
Backgrounds: Dietary phytochemical index (DPI) is an inexpensive method for estimating the amounts of phy-tochemicals in foods. No study has investigated the association between DPI and non-alcoholic fatty liver disease (NAFLD). Our study aimed to compare DPI in patients with NAFLD and the control group.Methods: This is a case-control study of 250 subjects with NAFLD and 450 healthy subjects attending the Metabolic Liver Disease Research Center as a referral center affiliated to Isfahan University of Medical Sciences. DPI was calculated based on data collected from a 168-item validated food frequency questionnaire. Socio-demographic data, physical activity, and anthropometric measures such as body weight, height, and waist circumference were determined.Results: In the final adjusted model, the odds ratio (OR) of NAFLD across the DPI tertiles decreased significantly (OR = 0.55, 95 %CI = 0.31-0.95) (P-trend = 0.03). The highest vs. lowest tertiles of vegetable and olives PI were significantly associated with a lower risk of NAFLD (OR and 95 % CI = 0.26 (0.14-0.47); OR and 95 % CI = 0.51 (0.29-0.90), p for trend < 0.001, respectively), however, there was no significant relation between other PI components and NAFLD.Conclusion: This case-control study suggested that a higher PI score is associated with a reduced chance of NAFLD after adjusting for confounding variables. In addition, the highest tertile of vegetable and olives PI was signif-icantly associated with a lower risk of NAFLD.
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