A high-protein retained PES hemodialysis membrane with tannic acid as a multifunctional modifier

A high protein retention polyethersulfone (PES) membrane was prepared by nonsolvent-induced phase separa-tion and surface coating, which exhibited enhanced hemocompatibility and antioxidant stress performance. The cross-linked network was constructed by tannic acid (TA) and alpha-lipoic acid (alpha-LA) on the surface of the membrane, which controlled the pores to a reasonable size. The enrichment of heparin-like groups on the membrane surface, implemented by hydrophobic interaction and click reaction, confers anticoagulant properties; the presence of a large number of phenolic hydroxyl groups from TA and the introduction of alpha-LA allows the modified membranes to intervene in oxidative stress. The hemocompatibility characterizations included plasma recalcification time (PRT), activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and hemolysis rate (HR). Additionally, the DPPH ABTS radical scavenging capacity was tested to evaluate the antioxidant performance. The results show that the modified membrane presents an outstanding protein retention rate (99.3%) along with permeability. In addition, the PRT is prolonged to 341.7 s, and the DPPH center dot scavenging ability reaches 0.74 mu mol center dot cm-2. The membranes can be easily prepared and present excellent comprehensive performance. This work provides a simple and facile strategy for the fabrication of hemodialysis membranes with controllable pore sizes.

Automated summary

A high protein retention polyethersulfone (PES) membrane was prepared by nonsolvent-induced phase separation and surface coating using tannic acid (TA) and alpha-lipoic acid (alpha-LA). The modified membrane exhibited enhanced hemocompatibility and antioxidant stress performance, making it a promising candidate for hemodialysis membranes.