Mussel-inspired adhesive zwitterionic composite hydrogel with antioxidant and antibacterial properties for wound healing

Article Nanoscience & Nanotechnology

Dendritic Hydrogels with Robust Inherent Antibacterial Properties for Promoting Bacteria-Infected Wound Healing

Siyao Cheng et al.

Summary: This study developed a new efficient synthetic strategy to prepare cationic hydrogels (PHCI) with intrinsic antimicrobial properties. In vivo experiments confirmed that the PHCI hydrogel can promote wound healing.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Facile Synthesis of Zn2+-Based Hybrid Nanoparticles as a New Paradigm for the Treatment of Internal Bacterial Infections

Yue Huang et al.

Summary: Transition metal ions have been used as sterilizing agents for thousands of years, but traditional metal or metal oxide nanoparticles cannot be directly medicated into the human body due to potential toxicity. Novel Zn2+-epsilon-poly(l-lysine)-protocatechuic aldehyde-based hybrid nanoparticles with on-demand release capability were synthesized for the first time in this study. These nanoparticles effectively adhere to bacterial cells, release Zn2+ in situ, exhibit excellent bactericidal ability, and show negligible toxicity, making them ideal candidates for treating internal infections.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Biochemistry & Molecular Biology

Highly Sensitive Multifunctional Electronic Skin Based on Nanocellulose/MXene Composite Films with Good Electromagnetic Shielding Biocompatible Antibacterial Properties

Dongning Liu et al.

Summary: A multifunctional electronic skin with excellent mechanical, electromagnetic shielding, biocompatibility, and antibacterial properties was successfully prepared using TOCN/Ti3C2TX composite film. The piezoresistive sensor assembled from the composite film exhibited high sensitivity, fast response and recovery time, ultralow monitoring limit, and long-term stability, and could detect human daily activities.

BIOMACROMOLECULES (2022)

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Article Chemistry, Applied

Superhydrophobic modification of nanocellulose based on an octadecylamine/dopamine system

Lingyuan Wang et al.

Summary: Super-hydrophobic nanocellulose films were prepared using a non-toxic octadecylamine/polydopamine system, with effects of reagent concentration, reaction temperature, and reaction time on hydrophobicity investigated. The results showed that specific conditions could effectively improve the hydrophobicity of nanocellulose.

CARBOHYDRATE POLYMERS (2022)

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Article Engineering, Multidisciplinary

Highly adhesive and dual-crosslinking hydrogel via one-pot self-initiated polymerization for efficient antibacterial, antifouling and full-thickness wound healing

Nuoya Zhao et al.

Summary: The multifunctional hydrogel dressing system with high adhesion and dual-crosslinking shows excellent antibacterial properties, cell compatibility and promotes wound healing effectively, making it a promising option for wound care.

COMPOSITES PART B-ENGINEERING (2022)

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Article Chemistry, Multidisciplinary

Revisiting the adhesion mechanism of mussel-inspired chemistry

Chao Zhang et al.

Summary: This study reveals a previously unexplored adhesion mechanism in mussel-inspired chemistry, where 5,6-dihydroxyindole (DHI) moieties play a crucial role, challenging the conventional belief of catechol-dominated adhesion. The high adhesion strength of polydopamine (PDA) is attributed to the abundant yield of DHI moieties achieved through oxidation and cyclization during self-polymerization, suggesting that substituent chemistry and self-polymerization can govern adhesion in mussel-inspired materials.

CHEMICAL SCIENCE (2022)

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Article Materials Science, Multidisciplinary

A dual-crosslinked self-healing and antibacterial nanocellulose hydrogel for monitoring of human motions

Luyu Zhang et al.

Summary: This study presents a dual-crosslinked hydrogel obtained by infiltrating a flexible polyvinyl alcohol network into the rigid network of bamboo cellulose. The hydrogel exhibits superior flexibility, shape controllability, self-healing ability, high ionic conductivity, and sensing capabilities. It also demonstrates potential for use in wearable products and as a green platform for creating eco-friendly and powerful functional composites.

MATERIALS & DESIGN (2022)

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Article Nanoscience & Nanotechnology

pH-Switchable Antimicrobial Supramolecular Hydrogels for Synergistically Eliminating Biofilm and Promoting Wound Healing

Huimin Chen et al.

Summary: This study develops pH-switchable antibacterial hydrogels based on self-assembled amphiphilic pentapeptides, which can eradicate biofilms and promote healing in infected wounds. In vitro experiments demonstrate that the hydrogels achieve antimicrobial effects through the release of pentapeptides and antibacterial oil. In vivo experiments show that the hydrogels can accelerate wound closure, reduce inflammation, and promote angiogenesis and collagen deposition.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Copper-Hydrazide Coordinated Multifunctional Hyaluronan Hydrogels for Infected Wound Healing

Junmin Qian et al.

Summary: In this study, a series of hyaluronan (HA)-metal hydrogels were successfully constructed using the hydrazide-metal coordination crosslinking method. The hydrazide-Cu(II) coordination imparted the HA-Cu hydrogel with physicochemical multifunctions, including self-healing, shear-thinning injectability, and reversible pH/redox/ion pair triple responsiveness. The HA-Cu hydrogel exhibited robust antibacterial activity and accelerated wound healing.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Materials Science, Multidisciplinary

A multifunctional mussel-inspired hydrogel with antioxidant, electrical conductivity and photothermal activity loaded with mupirocin for burn healing

Kai Han et al.

Summary: The remarkable role of hydrogels in promoting wound repair has been extensively studied, but developing hydrogels with multiple functions to address complex wound environments remains a challenge and focus of research. Inspired by mussel chemistry, dopamine-grafted gelatin and polydopamine-coated graphene oxide hydrogels were prepared. These hydrogels exhibited multifunctionality in terms of adhesion, conductivity, antioxidant activity, and antibacterial properties. The rheology, mechanical properties, and conductivity of the hydrogels could be adjusted by changing the concentration of graphene oxide. The hydrogels showed adhesive hemostasis in a rat liver hemorrhage model and demonstrated satisfactory photothermal antibacterial properties against both gram-positive and gram-negative bacteria. In vivo wound healing experiments confirmed the beneficial effect of the hydrogels in promoting burn wound healing. The GelDA/pGO hydrogels prepared in this study hold promise as multifunctional wound dressings for accelerating wound healing.

MATERIALS & DESIGN (2022)

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Article Chemistry, Applied

Synergistic antibacterial and wound-healing applications of an imidazole-based porous organic polymer encapsulated silver nanoparticles composite

Haotian Luo et al.

Summary: A novel antibacterial agent (IM-POP-Ag) was developed by encapsulating Ag nanoparticles into an imidazole-based porous organic polymer. It showed synergistic antibacterial and wound healing effects, effectively killing both Staphylococcus aureus and Escherichia coli bacteria. In vivo experiments on mice demonstrated that IM-POP-Ag significantly accelerated the healing rate of infected wounds.

MICROPOROUS AND MESOPOROUS MATERIALS (2022)

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Article Materials Science, Multidisciplinary

Porous photothermal antibacterial antioxidant dual - crosslinked cryogel based on hyaluronic acid/polydopamine for non-compressible hemostasis and infectious wound repair

Chunbo Wang et al.

Summary: This study developed a cryogel dressing with excellent antibacterial properties and water absorption ability. The cryogels demonstrated stable mechanical properties, antioxidant performance, and photothermal antibacterial ability. They showed great potential in preventing wound infections and treating infected wounds.

JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY (2022)

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Review Nanoscience & Nanotechnology

Biomaterials-Based Regenerative Strategies for Skin Tissue Wound Healing

Gurvinder Kaur et al.

Summary: Skin tissue wound healing involves four stages, namely hematoma formation, inflammation, neo-tissue formation, and tissue remodeling. Advanced biomaterials play a crucial role in these stages by providing functional advantages and serving as carriers for proteins/drug molecules/growth factors. Nanomaterial-based constructs and 3D bioprinting technique are emerging as promising approaches in wound healing.

ACS APPLIED BIO MATERIALS (2022)

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Review Materials Science, Biomaterials

Organic and inorganic antibacterial approaches in combating bacterial infection for biomedical application

Syafiqah Saidin et al.

Summary: This review paper explores the potential applications of inorganic and organic antibacterial agents in biomedical settings, discussing their mechanisms of action on Gram-negative and Gram-positive bacteria. Inorganic agents like silver, copper, gold, and zinc release ions to target Gram-negative bacteria, while organic agents like chlorhexidine and triclosan disrupt biochemical pathways in Gram-positive bacteria. The selection of antibacterial agents for biomaterials should consider their effective mechanisms and the specific bacterial strains they are targeting.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Chemistry, Physical

Molecularly Engineered Zwitterionic Hydrogels with High Toughness and Self-Healing Capacity for Soft Electronics Applications

Si Yu Zheng et al.

Summary: A new class of zwitterionic hydrogels, developed from a structurally ameliorated sulfobetaine monomer VBIPS, show significantly enhanced mechanical properties including excellent tensile toughness and fracture toughness. The toughness originates from the formation of a two-phase structure at room temperature, and the gel's mechanical properties can be tuned by changing the pH, with self-healing achieved through acid treatment.

CHEMISTRY OF MATERIALS (2021)

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Article Biochemistry & Molecular Biology

Zwitterionic Hydrogel with High Transparency, Ultrastretchability, and Remarkable Freezing Resistance for Wearable Strain Sensors

Qin Jiao et al.

Summary: This study presents the development of an ultrastretchable, highly transparent, and antifreezing zwitterionic-based electronic sensor that can maintain its toughness and transparency down to -40 degrees C. The zwitterionic hydrogel exhibits good biocompatibility and protein adsorption resistance. Such zwitterionic hydrogel-based strain sensors could be highly valuable for wearable electronic devices, especially in extreme environment applications.

BIOMACROMOLECULES (2021)

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Article Engineering, Environmental

One zwitterionic injectable hydrogel with ion conductivity enables efficient restoration of cardiac function after myocardial infarction

Yang Liu et al.

Summary: A cell-free and therapeutic drug-free injectable zwitterionic hydrogel with antioxidant ability and intrinsic conductive properties was fabricated, showing positive effects such as promoting cardiovascular growth and reducing cardiac fibrosis after injection into the infarcted region of rats.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Nanoscience & Nanotechnology

Moist-Retaining, Self-Recoverable, Bioadhesive, and Transparent in Situ Forming Hydrogels To Accelerate Wound Healing

Jun Li et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Dopamine-Modified Hyaluronic Acid Hydrogel Adhesives with Fast-Forming and High Tissue Adhesion

Ding Zhou et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Mussel-Inspired Hydrogels for Self-Adhesive Bioelectronics

Chaoming Xie et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Adhesive Hydrogel Patch with Enhanced Strength and Adhesiveness to Skin for Transdermal Drug Delivery

Hooyeon Jung et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Biochemistry & Molecular Biology

Recent Progress of Highly Adhesive Hydrogels as Wound Dressings

Liwei Zhang et al.

BIOMACROMOLECULES (2020)

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Article Materials Science, Biomaterials

Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing wearable strain sensor

Jing Zhang et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Nanoscience & Nanotechnology

Mussel-Inspired Adhesive Double-Network Hydrogel for Intraoral Ultrasound Imaging

Jiaqiang Yi et al.

ACS APPLIED BIO MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Bioinspired Self-Healing Human-Machine Interactive Touch Pad with Pressure-Sensitive Adhesiveness on Targeted Substrates

Guorong Gao et al.

ADVANCED MATERIALS (2020)

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Article Materials Science, Multidisciplinary

A Z-scheme heterojunction of ZnO/CDots/C3N4 for strengthened photoresponsive bacteria-killing and acceleration of wound healing

Yiming Xiang et al.

JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY (2020)

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Review Chemistry, Multidisciplinary

Mussel-inspired hydrogels: from design principles to promising applications

Chao Zhang et al.

CHEMICAL SOCIETY REVIEWS (2020)

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Article Chemistry, Multidisciplinary

Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full-Thickness Skin Regeneration During Wound Healing

Yongping Liang et al.

SMALL (2019)

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Article Engineering, Biomedical

Role of polydopamine's redox-activity on its pro-oxidant, radical-scavenging, and antimicrobial activities

Huan Liu et al.

ACTA BIOMATERIALIA (2019)

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Article Chemistry, Multidisciplinary

Rapid and Superior Bacteria Killing of Carbon Quantum Dots/ZnO Decorated Injectable Folic Acid-Conjugated PDA Hydrogel through Dual-Light Triggered ROS and Membrane Permeability

Yiming Xiang et al.

SMALL (2019)

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Article Chemistry, Multidisciplinary

Skin-Inspired Antibacterial Conductive Hydrogels for Epidermal Sensors and Diabetic Foot Wound Dressings

Yue Zhao et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Local Immunomodulation Using an Adhesive Hydrogel Loaded with miRNA-Laden Nanoparticles Promotes Wound Healing

Bahram Saleh et al.

SMALL (2019)

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Review Chemistry, Multidisciplinary

Versatile Polydopamine Platforms: Synthesis and Promising Applications for Surface Modification and Advanced Nanomedicine

Wei Cheng et al.

ACS NANO (2019)

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Article Nanoscience & Nanotechnology

Highly Stretchable, Adhesive, and Mechanical Zwitterionic Nanocomposite Hydrogel Biomimetic Skin

Bowen Yang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Nanoscience & Nanotechnology

Tough, Adhesive, Self-Healable, and Transparent Ionically Conductive Zwitterionic Nanocomposite Hydrogels as Skin Strain Sensors

Liufang Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Biophysics

Insights on the ultra high antibacterial activity of positionally substituted 2′-O-hydroxypropyl trimethyl ammonium chloride chitosan: A joint interaction of -NH2 and -N+ (CH3)3 with bacterial cell wall

Jianhui Li et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Materials Science, Biomaterials

Self-adhesive photothermal hydrogel films for solar-light assisted wound healing

Yujie Gao et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Review Dermatology

The relationship between skin function, barrier properties, and body-dependent factors

A. K. Dabrowska et al.

SKIN RESEARCH AND TECHNOLOGY (2018)

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Article Nanoscience & Nanotechnology

Highly Stretchable and Biocompatible Strain Sensors Based on Mussel-Inspired Super-Adhesive Self-Healing Hydrogels for Human Motion Monitoring

Xin Jing et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Review Nanoscience & Nanotechnology

Polydopamine Surface Chemistry: A Decade of Discovery

Ji Hyun Ryu et al.

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High efficiency visible-light-driven Fe2O3 -xSx/S-doped g-C3N4 heterojunction photocatalysts: Direct Z-scheme mechanism

Milad Jourshabani et al.

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Article Engineering, Biomedical

Antibacterial Activity of Silver Nanoparticles: Structural Effects

Shaoheng Tang et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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Article Nanoscience & Nanotechnology

Mussel-Inspired Tissue-Adhesive Hydrogel Based on the Polydopamine-Chondroitin Sulfate Complex for Growth-Factor-Free Cartilage Regeneration

Lu Han et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Chemistry, Physical

Synthesis of hierarchical porous zinc oxide (ZnO) microspheres with highly efficient adsorption of Congo red

Chunsheng Lei et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2017)

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Review Chemistry, Multidisciplinary

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Hirotaka Ejima et al.

NANO TODAY (2017)

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Toxicity of silver nanoparticles-Nanoparticle or silver ion?

Christiane Beer et al.

TOXICOLOGY LETTERS (2012)

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Review Chemistry, Multidisciplinary

A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment

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JOURNAL OF NANOPARTICLE RESEARCH (2010)

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Article Gastroenterology & Hepatology

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GASTROENTEROLOGY (2009)

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Review Toxicology

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ARCHIVES OF TOXICOLOGY (2006)

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Mussel-inspired adhesive zwitterionic composite hydrogel with antioxidant and antibacterial properties for wound healing

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