4.7 Article

Slippery liquid-infused porous surface (SLIPS) with super-repellent and contact-killing antimicrobial performances

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DOI: 10.1016/j.colsurfb.2022.112878

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Slippery liquid-infused porous surfaces; Super-repellent; Antibacterial; Coefficient of friction

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This study reports a slippery liquid-infused porous surface (SLIPS) with super-repellent and contact-killing antimicrobial performances. The surface is prepared by a simple microphase separation technique and covalent modification to achieve bactericidal activity. The SLIPS surface shows high super-repellence against bacteria and maintains antimicrobial activity even after the lubricant is depleted. Additionally, the surface exhibits reduced coefficient of friction and can be easily applied to various substrates.
Slippery liquid-filled porous surfaces (SLIPS) have attracted extensive research attention for their unique repellent properties, but such surfaces typically lack essential bactericidal activity and cannot defend against the spread of bacteria once bacterial contamination occurs. Herein, a slippery liquid-infused porous surface (SLIPS), endowed with both super-repellent and contact-killing antimicrobial performances is reported. Firstly, polystyrene (PS) based porous structures are developed via a facile microphase separation technique with poly(ethylene glycol) (PEG) as the sacrifice template. The porous surface was then covalently modified by 3-(trimethoxysilyl)propyl dimethyl undecyl ammonium chloride (QAC-Silane) to get the contact-killing antimicrobial performances. After lubricant (silicone oil) is introduced to the porous structure, the SLIPS surface demonstrates remarkably high super-repellence against both Gram-positive and negative bacteria, and also maintains essential contact-killing antimicrobial activities from the fixed QAC-11 groups, once the infused lubricant was depleted. Also, this surface demonstrates a reduced coefficient of friction (COF) of similar to 56% as compared to that of the control flat surface. Moreover, this SLIPS surface can be easily realized on various substrates, such as silica glass, polycarbonate (PC), polyethylene terephthalate (PET), polyethylene (PE) and silicone catheter tube. Owing to its simple, low-cost and fast fabrication approach, this kind of surface may find unique biomedical applications where an effective antibacterial performance and lubricity are highly needed.

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